| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ProQuest Associates IV LLC | 4,780,188 | 353,877,000 | 33.45% | ||
| 2 | Consonance Capital Management LP | 1,353,913 | 100,230,000 | 9.47% | ||
| 3 | JW Asset Management, LLC | 848,709 | 62,830,000 | 5.94% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 773,222 | 57,242,000 | 5.41% | ||
| 5 | VANGUARD GROUP INC | 573,951 | 42,490,000 | 4.02% | ||
| 6 | Park West Asset Management LLC | 500,591 | 37,059,000 | 3.50% | ||
| 7 | STATE STREET CORP | 428,986 | 31,754,000 | 3.00% | ||
| 8 | Ranger Investment Management, L.P. | 428,295 | 31,707,000 | 3.00% | ||
| 9 | Allianz Asset Management GmbH | 356,555 | 26,395,000 | 2.49% | ||
| 10 | GENERAL ELECTRIC CO | 336,992 | 24,948,000 | 2.36% | ||
| 11 | Cormorant Asset Management, LP | 300,000 | 22,209,000 | 2.10% | ||
| 12 | C WorldWide Group Holding A/S | 273,907 | 20,277,000 | 1.92% | ||
| 13 | HIGHLAND CAPITAL MANAGEMENT LP | 239,508 | 17,731,000 | 1.68% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 235,633 | 17,444,000 | 1.65% | ||
| 15 | BlackRock Fund Advisors | 204,499 | 15,139,000 | 1.43% | ||
| 16 | Invesco Ltd. | 160,732 | 11,899,000 | 1.12% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 123,044 | 9,109,000 | 0.86% | ||
| 18 | WALL STREET ASSOCIATES | 119,900 | 8,876,000 | 0.84% | ||
| 19 | NORTHERN TRUST CORP | 95,929 | 7,102,000 | 0.67% | ||
| 20 | Asset Management One Co., Ltd. | 93,141 | 6,880,000 | 0.65% | ||
| 21 | TWO SIGMA INVESTMENTS, LP | 90,870 | 6,727,000 | 0.64% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,900 | 6,285,000 | 0.59% | Put | |
| 23 | BANK OF MONTREAL /CAN/ | 73,882 | 5,469,000 | 0.52% | ||
| 24 | Opaleye Management Inc. | 73,200 | 5,419,000 | 0.51% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 69,809 | 5,167,000 | 0.49% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 65,678 | 4,862,000 | 0.46% | ||
| 27 | Bank of New York Mellon Corp | 61,675 | 4,566,000 | 0.43% | ||
| 28 | TWO SIGMA ADVISERS, LP | 60,200 | 4,470,000 | 0.42% | ||
| 29 | PUTNAM INVESTMENTS LLC | 57,350 | 4,246,000 | 0.40% | ||
| 30 | QS Investors, LLC | 57,097 | 4,227,000 | 0.40% | ||
| 31 | Nicholas Investment Partners, LP | 53,069 | 3,929,000 | 0.37% | ||
| 32 | RUSSELL FRANK CO/ | 51,463 | 3,810,000 | 0.36% | ||
| 33 | Century Capital Management, LLC | 49,267 | 3,647,000 | 0.34% | ||
| 34 | BLAIR WILLIAM & CO/IL | 47,754 | 3,535,000 | 0.33% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,200 | 3,494,000 | 0.33% | Call | |
| 36 | AQR CAPITAL MANAGEMENT LLC | 44,534 | 3,297,000 | 0.31% | ||
| 37 | GAM Holding AG | 42,700 | 3,161,000 | 0.30% | ||
| 38 | DEUTSCHE BANK AG\ | 42,527 | 3,147,000 | 0.30% | ||
| 39 | Informed Momentum Co LLC | 41,844 | 3,098,000 | 0.29% | ||
| 40 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 38,743 | 2,868,000 | 0.27% | ||
| 41 | PDT Partners, LLC | 36,152 | 2,676,000 | 0.25% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,798 | 2,354,000 | 0.22% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 30,728 | 2,275,000 | 0.22% | ||
| 44 | D. E. Shaw & Co., Inc. | 30,000 | 2,221,000 | 0.21% | Put | |
| 45 | BlackRock Investment Management, LLC | 28,816 | 2,133,000 | 0.20% | ||
| 46 | BLACKROCK ADVISORS LLC | 28,786 | 2,131,000 | 0.20% | ||
| 47 | SECTORAL ASSET MANAGEMENT INC | 28,152 | 2,084,000 | 0.20% | ||
| 48 | Timpani Capital Management LLC | 27,090 | 2,005,000 | 0.19% | ||
| 49 | PANAGORA ASSET MANAGEMENT INC | 26,841 | 1,987,000 | 0.19% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,251 | 1,944,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
