| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ProQuest Associates IV LLC | 4,780,188 | 193,598,000 | 29.84% | ||
| 2 | Park West Asset Management LLC | 1,472,197 | 59,624,000 | 9.19% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 1,447,539 | 58,627,000 | 9.04% | ||
| 4 | JW Asset Management, LLC | 760,379 | 30,795,000 | 4.75% | ||
| 5 | Consonance Capital Management LP | 693,937 | 28,104,000 | 4.33% | ||
| 6 | STATE STREET CORP | 629,493 | 25,489,000 | 3.93% | ||
| 7 | Cormorant Asset Management, LP | 500,000 | 20,250,000 | 3.12% | ||
| 8 | BlackRock Fund Advisors | 409,234 | 16,574,000 | 2.55% | ||
| 9 | Ranger Investment Management, L.P. | 404,155 | 16,368,000 | 2.52% | ||
| 10 | VANGUARD GROUP INC | 351,676 | 14,242,000 | 2.20% | ||
| 11 | GENERAL ELECTRIC CO | 336,992 | 13,648,000 | 2.10% | ||
| 12 | Allianz Asset Management GmbH | 266,347 | 10,788,000 | 1.66% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 237,671 | 9,626,000 | 1.48% | ||
| 14 | Point72 Asset Management, L.P. | 199,831 | 8,093,000 | 1.25% | ||
| 15 | C WorldWide Group Holding A/S | 198,907 | 8,056,000 | 1.24% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 187,215 | 7,582,000 | 1.17% | ||
| 17 | FMR LLC | 144,650 | 5,858,000 | 0.90% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 134,700 | 5,455,000 | 0.84% | Call | |
| 19 | Invesco Ltd. | 131,883 | 5,341,000 | 0.82% | ||
| 20 | BANK OF MONTREAL /CAN/ | 131,268 | 5,317,000 | 0.82% | ||
| 21 | AMERICAN CENTURY COMPANIES INC | 108,334 | 4,388,000 | 0.68% | ||
| 22 | Asset Management One Co., Ltd. | 104,911 | 4,097,000 | 0.63% | ||
| 23 | NORTHERN TRUST CORP | 100,366 | 4,065,000 | 0.63% | ||
| 24 | PUTNAM INVESTMENTS LLC | 93,108 | 3,770,000 | 0.58% | ||
| 25 | Century Capital Management, LLC | 85,069 | 3,445,000 | 0.53% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 78,503 | 3,179,000 | 0.49% | ||
| 27 | PANAGORA ASSET MANAGEMENT INC | 76,502 | 3,098,000 | 0.48% | ||
| 28 | QS Investors, LLC | 76,298 | 3,090,000 | 0.48% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,700 | 3,066,000 | 0.47% | Put | |
| 30 | GOLDMAN SACHS GROUP INC | 69,212 | 2,803,000 | 0.43% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 68,433 | 2,771,000 | 0.43% | ||
| 32 | BLAIR WILLIAM & CO/IL | 65,380 | 2,647,000 | 0.41% | ||
| 33 | CREDIT SUISSE AG/ | 63,465 | 2,570,000 | 0.40% | ||
| 34 | HIGHLAND CAPITAL MANAGEMENT LP | 61,081 | 2,474,000 | 0.38% | ||
| 35 | RUSSELL FRANK CO/ | 60,996 | 2,471,000 | 0.38% | ||
| 36 | Parallax Volatility Advisers, L.P. | 60,300 | 2,442,000 | 0.38% | Put | |
| 37 | Opaleye Management Inc. | 60,000 | 2,430,000 | 0.37% | ||
| 38 | GAM Holding AG | 58,800 | 2,381,000 | 0.37% | ||
| 39 | Candriam S.C.A. | 57,500 | 2,316,000 | 0.36% | ||
| 40 | J. Goldman & Co LP | 55,000 | 2,228,000 | 0.34% | Call | |
| 41 | BANK OF AMERICA CORP /DE/ | 52,600 | 2,130,000 | 0.33% | Call | |
| 42 | Healthcare Value Capital, LLC | 50,000 | 2,025,000 | 0.31% | Call | |
| 43 | WADDELL & REED FINANCIAL INC | 44,100 | 1,786,000 | 0.28% | ||
| 44 | Bank of New York Mellon Corp | 40,882 | 1,656,000 | 0.26% | ||
| 45 | GOLDMAN SACHS GROUP INC | 40,500 | 1,640,000 | 0.25% | Put | |
| 46 | GUGGENHEIM CAPITAL LLC | 36,850 | 1,492,000 | 0.23% | ||
| 47 | AQR CAPITAL MANAGEMENT LLC | 35,476 | 1,437,000 | 0.22% | ||
| 48 | WALL STREET ASSOCIATES | 35,200 | 1,426,000 | 0.22% | ||
| 49 | NEXTHERA CAPITAL LP | 33,000 | 1,337,000 | 0.21% | Put | |
| 50 | GSA CAPITAL PARTNERS LLP | 32,296 | 1,308,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
