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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q4)
Portfolio Summary: 118 holdings with a total value of $682,991,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 SPDR S&P 500 ETF TR PUT 400,000 81,548,000 11.94% Put
2 TEVA PHARMACEUTICAL INDS LTD 784,850 51,517,000 7.54%
3 ORMAT TECHNOLOGIES INC 272,462 38,744,000 5.67%
4 PFIZER INC 1,176,612 37,981,000 5.56%
5 BIOGEN INC 123,850 37,941,000 5.56%
6 ALLERGAN PLC 100,000 31,250,000 4.58%
7 SPDR S&P BIOTECH ETF 329,800 23,152,000 3.39% Put
8 ABBVIE INC 362,000 21,445,000 3.14%
9 CELGENE CORP 147,200 17,629,000 2.58%
10 MYLAN N.V. 300,000 16,221,000 2.37% Call
11 GILEAD SCIENCES INC 142,700 14,440,000 2.11%
12 ALEXION PHARMACEUTIC 59,164 11,286,000 1.65%
13 BRISTOL MYERS SQUIBB CO 121,500 8,358,000 1.22%
14 SHIRE PLC 40,000 8,200,000 1.20%
15 ACORDA THERAPEUTICS 143,000 6,118,000 0.90%
16 VERTEX PHARMACEUT 48,400 6,090,000 0.89%
17 FIVE PRIME THERAPEUTICS INC 145,000 6,018,000 0.88%
18 ISHARES NASDAQ BIOTECHNOLOGY ETF 7,409 5,764,000 0.84%
19 INCYTE 51,621 5,598,000 0.82%
20 SAGE THERAPEUTICS 93,000 5,422,000 0.79%
21 CELLCOM ISRAEL LTD 212,300 5,144,000 0.75%
22 IONIS PHARMACEUTICALS INC 81,200 5,029,000 0.74%
23 OPKO HEALTH INC 500,000 5,025,000 0.74%
24 MACROGENICS INC 153,000 4,738,000 0.69%
25 BELLICUM PHARMACEUTICALS INC COM 231,515 4,693,000 0.69%
26 CHECK POINT SOFTWARE TECH LT 55,857 4,546,000 0.67%
27 PORTOLA PHARMACEUTICALS INC 85,500 4,399,000 0.64%
28 MARINUS PHARMACEUTICALS INC 570,908 4,362,000 0.64%
29 RADIUS HEALTH 70,000 4,308,000 0.63%
30 VANDA PHARMACEUTICALS INC COM 462,051 4,302,000 0.63%
31 ADAMAS PHARMACEUTICALS INC 150,000 4,248,000 0.62%
32 INOTEK PHARMACEUTICALS CORP 360,000 4,079,000 0.60%
33 ALNYLAM PHARMACEUTICALS INC 40,000 3,766,000 0.55%
34 ALDER BIOPHARMACEUTICALS INC 112,500 3,716,000 0.54%
35 ORBOTECH LTD 167,619 3,709,000 0.54%
36 KEMPHARM INC 183,954 3,653,000 0.53%
37 HERON THERAPEUTICS INC 135,000 3,605,000 0.53%
38 GOOGLE INC 4,600 3,579,000 0.52% Call
39 ACADIA PHARMACEUTICALS INC COM 100,000 3,565,000 0.52%
40 CATALYST PHARMACEUTICALS INC 1,455,000 3,565,000 0.52%
41 RAPTOR PHARMACEUTICAL CORP 685,000 3,562,000 0.52%
42 GW PHARMACEUTICALS PLC 50,000 3,472,000 0.51% Call
43 VALEANT PHARMACEUTICALS INTL 33,750 3,431,000 0.50%
44 CONCERT PHARMACEUTICALS INC COM 180,000 3,415,000 0.50%
45 TJX COS INC NEW 47,961 3,401,000 0.50%
46 Anacor Pharmaceuticals Inc 30,000 3,389,000 0.50%
47 ADURO BIOTECH 120,000 3,377,000 0.49%
48 NOVAVAX INC COM 400,000 3,356,000 0.49%
49 CARA THERAPEUTICS INC 197,820 3,335,000 0.49%
50 CLOVIS ONCOLOGY INC 94,500 3,308,000 0.48%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-16-004256, filed 2016.02.11).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.