| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisors LLC | 2,214,043 | 25,594,000 | 20.27% | ||
| 2 | Aisling Capital LLC | 1,763,500 | 20,386,000 | 16.15% | ||
| 3 | Cormorant Asset Management, LP | 1,652,912 | 19,108,000 | 15.13% | ||
| 4 | VANGUARD GROUP INC | 587,814 | 6,795,000 | 5.38% | ||
| 5 | Numeric Investors LLC | 524,399 | 6,062,000 | 4.80% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 472,684 | 5,464,000 | 4.33% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 440,155 | 5,088,000 | 4.03% | ||
| 8 | Robert W. Baird & Co. Inc | 284,132 | 3,285,000 | 2.60% | ||
| 9 | C WorldWide Group Holding A/S | 262,301 | 3,032,000 | 2.40% | ||
| 10 | MORGAN STANLEY | 222,804 | 2,576,000 | 2.04% | ||
| 11 | DEUTSCHE BANK AG\ | 222,595 | 2,572,000 | 2.04% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,869 | 1,756,000 | 1.39% | ||
| 13 | Talkot Capital, LLC | 145,500 | 1,682,000 | 1.33% | ||
| 14 | Tekla Capital Management LLC | 142,597 | 1,648,000 | 1.31% | ||
| 15 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 132,322 | 1,530,000 | 1.21% | ||
| 16 | Healthcare Value Capital, LLC | 125,000 | 1,445,000 | 1.14% | ||
| 17 | TFS CAPITAL LLC | 117,983 | 1,364,000 | 1.08% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 109,700 | 1,268,000 | 1.00% | ||
| 19 | Spot Trading L.L.C | 105,000 | 1,214,000 | 0.96% | Put | |
| 20 | Endurant Capital Management LP | 97,940 | 1,132,000 | 0.90% | ||
| 21 | ACUTA CAPITAL PARTNERS, LLC | 80,000 | 925,000 | 0.73% | Call | |
| 22 | CITADEL ADVISORS LLC | 76,137 | 880,000 | 0.70% | ||
| 23 | Spot Trading L.L.C | 75,264 | 870,000 | 0.69% | ||
| 24 | TWO SIGMA INVESTMENTS, LP | 73,035 | 844,000 | 0.67% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,500 | 723,000 | 0.57% | Put | |
| 26 | CREDIT SUISSE AG/ | 59,532 | 689,000 | 0.55% | ||
| 27 | BlackRock Fund Advisors | 57,872 | 669,000 | 0.53% | ||
| 28 | BLACKROCK ADVISORS LLC | 56,177 | 649,000 | 0.51% | ||
| 29 | MARSHALL WACE, LLP | 44,352 | 513,000 | 0.41% | ||
| 30 | NORTHERN TRUST CORP | 42,582 | 493,000 | 0.39% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 45,200 | 480,000 | 0.38% | ||
| 32 | FMR LLC | 41,130 | 475,000 | 0.38% | ||
| 33 | BlueCrest Capital Management Ltd | 38,166 | 441,000 | 0.35% | ||
| 34 | PANAGORA ASSET MANAGEMENT INC | 38,023 | 440,000 | 0.35% | ||
| 35 | Allianz Asset Management GmbH | 35,940 | 415,000 | 0.33% | ||
| 36 | GOLDMAN SACHS GROUP INC | 30,700 | 355,000 | 0.28% | ||
| 37 | JPMORGAN CHASE & CO | 29,210 | 338,000 | 0.27% | ||
| 38 | GSA CAPITAL PARTNERS LLP | 25,889 | 299,000 | 0.24% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,500 | 295,000 | 0.23% | Call | |
| 40 | MATRIX ASSET ADVISORS INC/NY | 23,128 | 267,000 | 0.21% | ||
| 41 | Bank of New York Mellon Corp | 21,639 | 250,000 | 0.20% | ||
| 42 | TWO SIGMA ADVISERS, LP | 21,200 | 245,000 | 0.19% | ||
| 43 | Cubist Systematic Strategies, LLC | 17,620 | 204,000 | 0.16% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 15,491 | 179,000 | 0.14% | ||
| 45 | WELLS FARGO & COMPANY/MN | 15,214 | 176,000 | 0.14% | ||
| 46 | Spot Trading L.L.C | 13,200 | 153,000 | 0.12% | Call | |
| 47 | Spark Investment Management LLC | 13,300 | 153,000 | 0.12% | ||
| 48 | Virtu KCG Holdings LLC | 12,995 | 150,000 | 0.12% | ||
| 49 | STATE STREET CORP | 12,300 | 142,000 | 0.11% | ||
| 50 | Airain ltd | 11,972 | 138,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
