| 1 |
Avoro Capital Advisors LLC |
2,186,520 |
38,526,000 |
16.25% |
|
|
| 2 |
Cormorant Asset Management, LP |
1,945,334 |
34,277,000 |
14.46% |
|
|
| 3 |
Aisling Capital LLC |
1,703,855 |
30,022,000 |
12.67% |
|
|
| 4 |
VANGUARD GROUP INC |
749,822 |
13,212,000 |
5.57% |
|
|
| 5 |
BlackRock Fund Advisors |
741,646 |
13,068,000 |
5.51% |
|
|
| 6 |
Wildcat Capital Management, LLC |
736,012 |
12,968,000 |
5.47% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
647,506 |
11,409,000 |
4.81% |
|
|
| 8 |
FRANKLIN RESOURCES INC |
339,400 |
5,980,000 |
2.52% |
|
|
| 9 |
BAIRD FINANCIAL GROUP, INC. |
305,791 |
5,388,000 |
2.27% |
|
|
| 10 |
STATE STREET CORP |
293,275 |
5,171,000 |
2.18% |
|
|
| 11 |
DEUTSCHE BANK AG\ |
268,096 |
4,722,000 |
1.99% |
|
|
| 12 |
Informed Momentum Co LLC |
249,028 |
4,388,000 |
1.85% |
|
|
| 13 |
C WorldWide Group Holding A/S |
222,301 |
3,917,000 |
1.65% |
|
|
| 14 |
ACUTA CAPITAL PARTNERS, LLC |
212,402 |
3,743,000 |
1.58% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
204,099 |
3,596,000 |
1.52% |
|
|
| 16 |
Bank of New York Mellon Corp |
170,723 |
3,008,000 |
1.27% |
|
|
| 17 |
TFS CAPITAL LLC |
150,812 |
2,657,000 |
1.12% |
|
|
| 18 |
MORGAN STANLEY |
148,429 |
2,616,000 |
1.10% |
|
|
| 19 |
Numeric Investors LLC |
142,771 |
2,516,000 |
1.06% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
136,549 |
2,406,000 |
1.02% |
|
|
| 21 |
MILLENNIUM MANAGEMENT LLC |
133,270 |
2,348,000 |
0.99% |
|
|
| 22 |
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
132,322 |
2,332,000 |
0.98% |
|
|
| 23 |
HIGHLAND CAPITAL MANAGEMENT LP |
115,000 |
2,027,000 |
0.86% |
|
|
| 24 |
AMERIPRISE FINANCIAL INC |
102,301 |
1,802,000 |
0.76% |
|
|
| 25 |
BlackRock Investment Management, LLC |
100,547 |
1,772,000 |
0.75% |
|
|
| 26 |
PDT Partners, LLC |
97,667 |
1,721,000 |
0.73% |
|
|
| 27 |
NORTHERN TRUST CORP |
85,317 |
1,503,000 |
0.63% |
|
|
| 28 |
BLACKROCK ADVISORS LLC |
70,536 |
1,243,000 |
0.52% |
|
|
| 29 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
69,857 |
1,231,000 |
0.52% |
|
|
| 30 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
69,500 |
1,225,000 |
0.52% |
|
|
| 31 |
CITADEL ADVISORS LLC |
68,191 |
1,202,000 |
0.51% |
|
|
| 32 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
57,900 |
1,020,000 |
0.43% |
Call |
|
| 33 |
RENAISSANCE TECHNOLOGIES LLC |
57,547 |
1,014,000 |
0.43% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
51,809 |
913,000 |
0.39% |
|
|
| 35 |
Healthcare Value Capital, LLC |
50,000 |
881,000 |
0.37% |
|
|
| 36 |
RUSSELL FRANK CO/ |
44,445 |
783,000 |
0.33% |
|
|
| 37 |
Granite Investment Partners, LLC |
43,861 |
772,000 |
0.33% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
41,484 |
731,000 |
0.31% |
|
|
| 39 |
FMR LLC |
41,130 |
725,000 |
0.31% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
40,955 |
722,000 |
0.30% |
|
|
| 41 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
29,700 |
523,000 |
0.22% |
Put |
|
| 42 |
Trexquant Investment LP |
28,300 |
498,000 |
0.21% |
|
|
| 43 |
RHUMBLINE ADVISERS |
23,950 |
422,000 |
0.18% |
|
|
| 44 |
MATRIX ASSET ADVISORS INC/NY |
23,128 |
408,000 |
0.17% |
|
|
| 45 |
METROPOLITAN LIFE INSURANCE CO/NY |
20,949 |
369,000 |
0.16% |
|
|
| 46 |
PANAGORA ASSET MANAGEMENT INC |
20,641 |
364,000 |
0.15% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
18,823 |
331,661 |
0.14% |
|
|
| 48 |
Nationwide Fund Advisors |
18,347 |
323,000 |
0.14% |
|
|
| 49 |
NEW YORK STATE COMMON RETIREMENT FUND |
18,294 |
322,000 |
0.14% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
17,598 |
310,000 |
0.13% |
|
|
