Dark
Light
System
Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q4)
Portfolio Summary: 104 holdings with a total value of $395,050,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 SPDR S&P BIOTECH ETF 550,000 32,555,000 8.24% Put
2 MERCK & CO INC 450,000 26,492,000 6.71%
3 CELGENE CORP 180,000 20,835,000 5.27%
4 TEVA PHARMACEUTICAL INDS LTD 522,000 18,923,000 4.79%
5 ALEXION PHARMACEUTIC 113,000 13,826,000 3.50%
6 ISHARES TR 100,000 13,485,000 3.41% Put
7 ISHARES TR 100,000 13,485,000 3.41% Call
8 COLUCID PHARMACEUTICALS INC COM 358,000 13,031,000 3.30%
9 SAREPTA THERAPEUTICS INC 398,047 10,918,000 2.76%
10 ITURAN LOCATION AND CONTROL LTD 306,633 8,126,000 2.06%
11 ARRAY BIOPHARMA INC COM 900,000 7,911,000 2.00%
12 TEVA PHARMACEUTICAL INDUSTRIES LTD 215,000 7,794,000 1.97% Call
13 ACHAOGEN INC COM 514,342 6,697,000 1.70%
14 Ascendis Pharma 326,622 6,611,000 1.67%
15 SHIRE PLC 32,500 5,537,000 1.40%
16 HORIZON PHARMA PLC 300,000 4,854,000 1.23%
17 CHARTER COMM 16,165 4,654,000 1.18%
18 SELECTA BIOSCIENCES INC 268,534 4,605,000 1.17%
19 SAGE THERAPEUTICS 90,000 4,595,000 1.16%
20 CORVUS PHARMACEUTICALS INC COM 320,229 4,579,000 1.16%
21 ADAMAS PHARMACEUTICALS INC 270,000 4,563,000 1.16%
22 ALPHABET INC 5,748 4,555,000 1.15%
23 GLYCOMIMETICS INC 745,796 4,549,000 1.15%
24 EIGER BIOPHARMACEUTICALS INC 385,301 4,489,000 1.14%
25 TEVA PHARMACEUTICAL FIN LLC 6,585 4,247,000 1.08%
26 VISA INC 51,951 4,053,000 1.03%
27 NEURODERM LTD 175,951 3,906,000 0.99%
28 IMMUNOMEDICS INC 1,050,000 3,854,000 0.98%
29 Foamix Pharmaceuticals Ltd. 342,000 3,796,000 0.96%
30 UNION PAC CORP 36,076 3,740,000 0.95%
31 BIOMARIN 45,000 3,728,000 0.94%
32 VERSARTIS INC COM 250,000 3,725,000 0.94%
33 AMICUS THERAPEUTICS INC 730,000 3,628,000 0.92%
34 FIBROGEN INC COM 155,700 3,332,000 0.84%
35 VERTEX PHARMACEUT 45,000 3,315,000 0.84%
36 FIDELITY NATL INFORMATION SV 43,503 3,291,000 0.83%
37 AIR PRODS & CHEMS INC 21,165 3,044,000 0.77%
38 SCHLUMBERGER LTD 34,361 2,885,000 0.73%
39 GENOCEA BIOSCIENCES INC 696,273 2,869,000 0.73%
40 DBV TECHNOLOGIES 79,058 2,777,000 0.70%
41 RETROPHIN INC COM 143,974 2,725,000 0.69%
42 ADVANCE AUTO PARTS INC 16,059 2,716,000 0.69%
43 TESARO INC 20,000 2,690,000 0.68%
44 Clearside Biomedical Inc 300,000 2,682,000 0.68%
45 ISHARES TR 12,000 2,682,000 0.68% Put
46 NICE LTD 38,323 2,635,000 0.67%
47 ACCELERON PHARMA 100,000 2,552,000 0.65%
48 STARBUCKS CORP 45,631 2,533,000 0.64%
49 XENON PHARMACEUTICALS INC 328,029 2,526,000 0.64%
50 INOTEK PHARMACEUTICALS CORP 401,764 2,451,000 0.62%
Page 1 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-17-000411, filed 2017.02.13).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.