| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,332,783 | 331,112,000 | 16.83% | ||
| 2 | Capital Research Global Investors | 4,275,086 | 265,440,000 | 13.49% | ||
| 3 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 2,244,710 | 139,374,000 | 7.08% | ||
| 4 | TPG Group Holdings (SBS) Advisors, Inc. | 1,596,420 | 99,122,000 | 5.04% | ||
| 5 | VANGUARD GROUP INC | 1,595,226 | 99,047,000 | 5.03% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,574,844 | 97,783,000 | 4.97% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,245,840 | 77,354,000 | 3.93% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 981,846 | 60,963,000 | 3.10% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000 | 58,986,000 | 3.00% | ||
| 10 | Visium Asset Management, LP | 737,496 | 45,792,000 | 2.33% | ||
| 11 | JENNISON ASSOCIATES LLC | 735,614 | 45,674,000 | 2.32% | ||
| 12 | BlackRock Fund Advisors | 635,055 | 39,431,000 | 2.00% | ||
| 13 | LORD, ABBETT & CO. LLC | 628,332 | 39,013,000 | 1.98% | ||
| 14 | CITADEL ADVISORS LLC | 621,473 | 38,587,000 | 1.96% | ||
| 15 | STATE STREET CORP | 519,987 | 32,285,000 | 1.64% | ||
| 16 | FIL Ltd | 517,014 | 32,101,000 | 1.63% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 513,123 | 31,860,000 | 1.62% | ||
| 18 | OppenheimerFunds, Inc. | 509,157 | 31,613,000 | 1.61% | ||
| 19 | BLACKROCK ADVISORS LLC | 447,156 | 27,764,000 | 1.41% | ||
| 20 | FEDERATED HERMES, INC. | 398,600 | 24,749,000 | 1.26% | ||
| 21 | Redmile Group, LLC | 332,600 | 20,651,000 | 1.05% | ||
| 22 | Polar Capital LLP | 325,528 | 20,212,000 | 1.03% | ||
| 23 | RS INVESTMENT MANAGEMENT CO LLC | 325,161 | 20,189,000 | 1.03% | ||
| 24 | ALLIANCEBERNSTEIN L.P. | 304,185 | 18,887,000 | 0.96% | ||
| 25 | FRANKLIN RESOURCES INC | 214,300 | 13,306,000 | 0.68% | ||
| 26 | GOLDMAN SACHS GROUP INC | 206,572 | 12,826,000 | 0.65% | ||
| 27 | JPMORGAN CHASE & CO | 206,430 | 12,817,000 | 0.65% | ||
| 28 | Iguana Healthcare Management, LLC | 175,000 | 10,866,000 | 0.55% | ||
| 29 | BAKER BROS. ADVISORS LP | 148,894 | 9,245,000 | 0.47% | ||
| 30 | Capital World Investors | 145,000 | 9,003,000 | 0.46% | ||
| 31 | Weiss Multi-Strategy Advisers LLC | 143,432 | 8,906,000 | 0.45% | ||
| 32 | Cupps Capital Management, LLC | 142,634 | 8,856,000 | 0.45% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 139,849 | 8,683,000 | 0.44% | ||
| 34 | MARSHALL WACE, LLP | 122,613 | 7,613,000 | 0.39% | ||
| 35 | BROWN ADVISORY INC | 121,840 | 7,564,000 | 0.38% | ||
| 36 | AXA S.A. | 114,976 | 7,139,000 | 0.36% | ||
| 37 | NORTHERN TRUST CORP | 111,688 | 6,935,000 | 0.35% | ||
| 38 | Opaleye Management Inc. | 110,000 | 6,830,000 | 0.35% | ||
| 39 | BlackRock Group LTD | 106,018 | 6,582,000 | 0.33% | ||
| 40 | Cormorant Asset Management, LP | 102,000 | 6,333,000 | 0.32% | ||
| 41 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 94,452 | 5,864,000 | 0.30% | ||
| 42 | Rock Springs Capital Management LP | 92,000 | 5,712,000 | 0.29% | ||
| 43 | FRED ALGER MANAGEMENT, LLC | 81,698 | 5,073,000 | 0.26% | ||
| 44 | Bank of New York Mellon Corp | 81,677 | 5,071,000 | 0.26% | ||
| 45 | MORGAN STANLEY | 70,992 | 4,408,000 | 0.22% | ||
| 46 | CQS Cayman LP | 70,000 | 4,346,000 | 0.22% | ||
| 47 | EVENTIDE ASSET MANAGEMENT, LLC | 69,000 | 4,284,000 | 0.22% | ||
| 48 | EMERALD ADVISERS, LLC | 70,701 | 4,207,000 | 0.21% | ||
| 49 | PUTNAM INVESTMENTS LLC | 64,680 | 4,016,000 | 0.20% | ||
| 50 | Candriam S.C.A. | 60,000 | 3,726,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
