| 1 |
FMR LLC |
2,077,213 |
104,692,000 |
11.41% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,869,192 |
94,208,000 |
10.26% |
|
|
| 3 |
Bank of New York Mellon Corp |
1,431,455 |
72,146,000 |
7.86% |
|
|
| 4 |
VANGUARD GROUP INC |
1,201,417 |
60,552,000 |
6.60% |
|
|
| 5 |
FRONTIER CAPITAL MANAGEMENT CO LLC |
1,065,494 |
53,701,000 |
5.85% |
|
|
| 6 |
Capital World Investors |
799,100 |
40,275,000 |
4.39% |
|
|
| 7 |
JANUS HENDERSON INVESTORS US LLC |
746,078 |
37,602,000 |
4.10% |
|
|
| 8 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
729,400 |
36,762,000 |
4.01% |
|
|
| 9 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
678,484 |
34,196,000 |
3.73% |
|
|
| 10 |
PRICE T ROWE ASSOCIATES INC /MD/ |
595,221 |
29,999,000 |
3.27% |
|
|
| 11 |
FRANKLIN RESOURCES INC |
568,931 |
28,674,000 |
3.12% |
|
|
| 12 |
HUDSON EXECUTIVE CAPITAL LP |
520,258 |
26,221,000 |
2.86% |
|
|
| 13 |
CITADEL ADVISORS LLC |
513,054 |
25,858,000 |
2.82% |
|
|
| 14 |
BlackRock Fund Advisors |
479,350 |
24,159,000 |
2.63% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
446,102 |
22,484,000 |
2.45% |
|
|
| 16 |
ROYAL BANK OF CANADA |
410,535 |
20,692,000 |
2.25% |
|
|
| 17 |
STATE STREET CORP |
297,889 |
15,007,000 |
1.64% |
|
|
| 18 |
Palo Alto Investors LP |
246,068 |
12,402,000 |
1.35% |
|
|
| 19 |
Engaged Capital LLC |
230,000 |
11,592,000 |
1.26% |
|
|
| 20 |
NORTHERN TRUST CORP |
222,171 |
11,198,000 |
1.22% |
|
|
| 21 |
SECTORAL ASSET MANAGEMENT INC |
204,008 |
10,282,000 |
1.12% |
|
|
| 22 |
JPMORGAN CHASE & CO |
184,286 |
9,289,000 |
1.01% |
|
|
| 23 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
180,752 |
9,109,000 |
0.99% |
|
|
| 24 |
Rock Springs Capital Management LP |
160,669 |
8,098,000 |
0.88% |
|
|
| 25 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
159,961 |
8,062,000 |
0.88% |
|
|
| 26 |
Numeric Investors LLC |
135,085 |
6,808,000 |
0.74% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
112,309 |
5,660,000 |
0.62% |
|
|
| 28 |
TWO SIGMA ADVISERS, LP |
107,651 |
5,426,000 |
0.59% |
|
|
| 29 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
95,010 |
4,788,000 |
0.52% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
75,089 |
3,784,000 |
0.41% |
|
|
| 31 |
Asset Management One Co., Ltd. |
73,428 |
3,741,000 |
0.41% |
|
|
| 32 |
Iguana Healthcare Management, LLC |
70,000 |
3,528,000 |
0.38% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
69,700 |
3,513,000 |
0.38% |
Put |
|
| 34 |
Rhenman & Partners Asset Management AB |
67,000 |
3,377,000 |
0.37% |
|
|
| 35 |
GOLDMAN SACHS GROUP INC |
65,100 |
3,281,000 |
0.36% |
Put |
|
| 36 |
STATE FARM MUTUAL AUTOMOBILE INSURANCE CO |
58,800 |
2,964,000 |
0.32% |
|
|
| 37 |
PRUDENTIAL FINANCIAL INC |
58,764 |
2,962,000 |
0.32% |
|
|
| 38 |
BlackRock Investment Management, LLC |
58,426 |
2,945,000 |
0.32% |
|
|
| 39 |
GOLDMAN SACHS GROUP INC |
57,156 |
2,881,000 |
0.31% |
|
|
| 40 |
AMERIPRISE FINANCIAL INC |
55,521 |
2,798,000 |
0.30% |
|
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
53,560 |
2,700,000 |
0.29% |
|
|
| 42 |
Pentwater Capital Management LP |
50,000 |
2,520,000 |
0.27% |
|
|
| 43 |
RENAISSANCE TECHNOLOGIES LLC |
50,000 |
2,520,000 |
0.27% |
|
|
| 44 |
ALLIANCEBERNSTEIN L.P. |
41,608 |
2,177,000 |
0.24% |
|
|
| 45 |
Spark Investment Management LLC |
43,000 |
2,167,000 |
0.24% |
|
|
| 46 |
NORGES BANK |
39,948 |
2,013,000 |
0.22% |
|
|
| 47 |
A.R.T. Advisors, LLC |
39,012 |
1,966,000 |
0.21% |
|
|
| 48 |
ACUTA CAPITAL PARTNERS, LLC |
34,587 |
1,743,000 |
0.19% |
|
|
| 49 |
DEUTSCHE BANK AG\ |
33,926 |
1,708,000 |
0.19% |
|
|
| 50 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
32,018 |
1,614,000 |
0.18% |
|
|
