| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FLAGSHIP VENTURES MANAGEMENT, INC. | 4,806,656 | 77,339,000 | 30.80% | ||
| 2 | FMR LLC | 3,926,998 | 63,185,000 | 25.16% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,268,945 | 20,417,000 | 8.13% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 995,088 | 16,011,000 | 6.38% | ||
| 5 | Redmile Group, LLC | 973,260 | 15,660,000 | 6.24% | ||
| 6 | BAKER BROS. ADVISORS LP | 574,835 | 9,249,000 | 3.68% | ||
| 7 | BlackRock Finance, Inc. | 544,530 | 8,762,000 | 3.49% | ||
| 8 | Aisling Capital LLC | 508,565 | 8,183,000 | 3.26% | ||
| 9 | VANGUARD GROUP INC | 382,603 | 6,156,000 | 2.45% | ||
| 10 | Cormorant Asset Management, LP | 296,296 | 4,767,000 | 1.90% | SH | |
| 11 | CASDIN CAPITAL, LLC | 182,141 | 2,931,000 | 1.17% | ||
| 12 | STATE STREET CORP | 169,497 | 2,728,000 | 1.09% | ||
| 13 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 2,414,000 | 0.96% | ||
| 14 | AWM Investment Company, Inc. | 121,624 | 1,957,000 | 0.78% | ||
| 15 | Opaleye Management Inc. | 109,500 | 1,762,000 | 0.70% | ||
| 16 | JPMORGAN CHASE & CO | 109,200 | 1,757,000 | 0.70% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 83,821 | 1,348,000 | 0.54% | ||
| 18 | NORTHERN TRUST CORP | 58,070 | 935,000 | 0.37% | ||
| 19 | Weiss Multi-Strategy Advisers LLC | 45,500 | 732,000 | 0.29% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 34,390 | 553,000 | 0.22% | ||
| 21 | Bank of New York Mellon Corp | 30,024 | 483,000 | 0.19% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 27,000 | 434,000 | 0.17% | ||
| 23 | TEACHERS ADVISORS, LLC | 22,718 | 366,000 | 0.15% | ||
| 24 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,200 | 357,000 | 0.14% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,300 | 343,000 | 0.14% | ||
| 26 | ARK INVESTMENT MANAGEMENT LLC | 17,705 | 285,000 | 0.11% | ||
| 27 | MORGAN STANLEY | 14,597 | 235,000 | 0.09% | ||
| 28 | DEUTSCHE BANK AG\ | 14,679 | 234,000 | 0.09% | ||
| 29 | WELLS FARGO & COMPANY/MN | 14,100 | 227,000 | 0.09% | ||
| 30 | NEW YORK STATE COMMON RETIREMENT FUND | 13,400 | 216,000 | 0.09% | ||
| 31 | RHUMBLINE ADVISERS | 12,317 | 198,000 | 0.08% | ||
| 32 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,559 | 170,000 | 0.07% | ||
| 33 | METROPOLITAN LIFE INSURANCE CO/NY | 9,696 | 156,000 | 0.06% | ||
| 34 | GLENMEDE TRUST CO NA | 9,324 | 148,000 | 0.06% | ||
| 35 | AMERICAN INTERNATIONAL GROUP, INC. | 7,760 | 125,000 | 0.05% | ||
| 36 | Nationwide Fund Advisors | 7,024 | 113,000 | 0.05% | ||
| 37 | Legal & General Group Plc | 2,187 | 36,000 | 0.01% | ||
| 38 | STRS OHIO | 1,500 | 24,000 | 0.01% | ||
| 39 | BNP PARIBAS FINANCIAL MARKETS | 1,339 | 21,545 | 0.01% | ||
| 40 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,205 | 19,000 | 0.01% | ||
| 41 | PANAGORA ASSET MANAGEMENT INC | 1,146 | 18,000 | 0.01% | ||
| 42 | Ameritas Investment Partners, Inc. | 1,098 | 18,000 | 0.01% | ||
| 43 | UBS Group AG | 807 | 13,000 | 0.01% | ||
| 44 | Creative Planning | 675 | 11,000 | 0.00% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 312 | 5,000 | 0.00% | ||
| 46 | MEEDER ASSET MANAGEMENT INC | 242 | 4,000 | 0.00% | ||
| 47 | CITIGROUP INC | 83 | 1,000 | 0.00% | ||
| 48 | BARCLAYS PLC | 8 | 0 | 0.00% | ||
| 49 | ROYAL BANK OF CANADA | 22 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
