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Institutional Investment Manager
RA CAPITAL MANAGEMENT, L.P.
RA CAPITAL MANAGEMENT, L.P. (CIK: 0001346824) incorporated in Delaware, located at 200 Berkeley Street, 18th Floor, Boston, MA. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q4)
Portfolio Summary: 26 holdings with a total value of $684,730,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 WAVE LIFE SCIENCES LTD 7,088,651 185,368,000 27.07%
2 Ascendis Pharma 5,409,990 109,498,000 15.99%
3 AVEXIS INC COM 1,890,796 90,248,000 13.18%
4 ACHILLION PHARMACEUTICALS INC COM 13,633,220 56,305,000 8.22%
5 Aquinox Pharmaceuticals Inc 2,191,977 36,190,000 5.29%
6 ZOGENIX INC 2,451,237 29,783,000 4.35%
7 ARDELYX INC COM 1,935,305 27,481,000 4.01%
8 Foamix Pharmaceuticals Ltd. 1,820,138 20,204,000 2.95%
9 BIOCRYST PHARMACEUTICALS 2,989,795 18,925,000 2.76%
10 RA PHARMACEUTICALS INC 1,190,270 18,080,000 2.64%
11 Protagonist Therapeutics, Inc. 692,563 14,634,000 2.14%
12 AIMMUNE THERAPEUTICS INC COM 677,663 13,858,000 2.02%
13 Audentes Therapeutics, Inc. 532,426 9,727,000 1.42%
14 BEIGENE LTD 240,000 7,286,000 1.06%
15 Dicerna Pharmaceuticals 2,428,571 6,994,000 1.02%
16 ABEONA THERAPEUTICS INC 1,142,857 5,543,000 0.81%
17 Strongbridge Biopharma plc 2,279,099 5,470,000 0.80%
18 TG THERAPEUTICS INC COM 1,004,314 4,670,000 0.68%
19 TENAX THERAPEUTICS INC COM 2,389,700 4,660,000 0.68%
20 KALVISTA PHARMACEUTICALS INC 591,070 4,179,000 0.61%
21 EIGER BIOPHARMACEUTICALS INC 354,200 4,126,000 0.60%
22 DIMENSION THERAPEUTICS INC COM 928,199 4,038,000 0.59%
23 IDERA PHARMACEUTICALS INC 2,250,000 3,375,000 0.49%
24 MEDICINES CO 79,899 2,712,000 0.40%
25 AKARI THERAPEUTICS PLC 101,439 714,000 0.10%
26 ARCA BIOPHARMA INCORPORATED COM PAR .001 232,245 662,000 0.10%

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-17-008904, filed 2017.02.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.