| 1 |
NEA Management Company, LLC |
8,584,128 |
46,612,000 |
44.88% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
3,216,751 |
17,467,000 |
16.82% |
|
|
| 3 |
BVF INC/IL |
2,826,282 |
15,347,000 |
14.78% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
999,979 |
5,430,000 |
5.23% |
|
|
| 5 |
SPHERA FUNDS MANAGEMENT LTD. |
775,796 |
4,213,000 |
4.06% |
|
|
| 6 |
BlackRock Finance, Inc. |
513,858 |
2,791,000 |
2.69% |
|
|
| 7 |
VANGUARD GROUP INC |
434,501 |
2,359,000 |
2.27% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
381,235 |
2,070,000 |
1.99% |
|
|
| 9 |
Cormorant Asset Management, LP |
287,031 |
1,559,000 |
1.50% |
|
|
| 10 |
Candriam S.C.A. |
160,000 |
869,000 |
0.84% |
|
|
| 11 |
STATE STREET CORP |
137,098 |
745,000 |
0.72% |
|
|
| 12 |
NORTHERN TRUST CORP |
119,205 |
648,000 |
0.62% |
|
|
| 13 |
DEUTSCHE BANK AG\ |
98,351 |
533,000 |
0.51% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
94,985 |
515,000 |
0.50% |
|
|
| 15 |
RENAISSANCE TECHNOLOGIES LLC |
86,000 |
467,000 |
0.45% |
|
|
| 16 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
68,991 |
375,000 |
0.36% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
66,764 |
363,000 |
0.35% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
43,767 |
238,000 |
0.23% |
|
|
| 19 |
Bank of New York Mellon Corp |
35,820 |
195,000 |
0.19% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
30,934 |
168,000 |
0.16% |
|
|
| 21 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
24,076 |
131,000 |
0.13% |
|
|
| 22 |
Nationwide Fund Advisors |
21,924 |
119,000 |
0.11% |
|
|
| 23 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,600 |
107,000 |
0.10% |
|
|
| 24 |
MORGAN STANLEY |
15,723 |
85,000 |
0.08% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
14,375 |
78,000 |
0.08% |
|
|
| 26 |
RUSSELL INVESTMENTS GROUP, LTD. |
11,520 |
63,000 |
0.06% |
|
|
| 27 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,975 |
49,000 |
0.05% |
|
|
| 28 |
BARCLAYS PLC |
8,719 |
47,000 |
0.05% |
|
|
| 29 |
JPMORGAN CHASE & CO |
7,715 |
42,000 |
0.04% |
|
|
| 30 |
PRENTISS SMITH & CO INC |
7,000 |
38,000 |
0.04% |
|
|
| 31 |
WELLS FARGO & COMPANY/MN |
6,813 |
37,000 |
0.04% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,379 |
35,000 |
0.03% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
2,216 |
12,000 |
0.01% |
|
|
| 34 |
First Personal Financial Services |
1,911 |
10,000 |
0.01% |
|
|
| 35 |
UBS Group AG |
1,809 |
10,000 |
0.01% |
|
|
| 36 |
PERENNIAL ADVISORS, LLC |
1,500 |
8,000 |
0.01% |
|
|
| 37 |
Legal & General Group Plc |
1,315 |
7,000 |
0.01% |
|
|
| 38 |
Tower Research Capital LLC (TRC) |
914 |
5,000 |
0.00% |
|
|
| 39 |
MEEDER ASSET MANAGEMENT INC |
678 |
4,000 |
0.00% |
|
|
| 40 |
Ameritas Investment Partners, Inc. |
798 |
4,000 |
0.00% |
|
|
| 41 |
BANCO ITAU HOLDING FINANCEIRA S A |
467 |
3,000 |
0.00% |
|
|
| 42 |
ROYAL BANK OF CANADA |
488 |
3,000 |
0.00% |
|
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
159 |
1,000 |
0.00% |
|
|
| 44 |
STRS OHIO |
0 |
0 |
0.00% |
|
|
| 45 |
CITIGROUP INC |
27 |
0 |
0.00% |
|
|
