| 1 |
NEA Management Company, LLC |
8,584,128 |
62,407,000 |
46.39% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
2,710,310 |
19,704,000 |
14.65% |
|
|
| 3 |
BVF INC/IL |
2,447,415 |
17,793,000 |
13.23% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
1,009,979 |
7,343,000 |
5.46% |
|
|
| 5 |
SPHERA FUNDS MANAGEMENT LTD. |
718,080 |
5,220,000 |
3.88% |
|
|
| 6 |
VANGUARD GROUP INC |
392,892 |
2,857,000 |
2.12% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
381,235 |
2,772,000 |
2.06% |
|
|
| 8 |
Cormorant Asset Management, LP |
287,031 |
2,087,000 |
1.55% |
|
|
| 9 |
BlackRock Fund Advisors |
269,857 |
1,962,000 |
1.46% |
|
|
| 10 |
Candriam S.C.A. |
160,000 |
1,163,000 |
0.86% |
|
|
| 11 |
WALL STREET ASSOCIATES |
150,000 |
1,090,000 |
0.81% |
|
|
| 12 |
Invesco Ltd. |
117,562 |
855,000 |
0.64% |
|
|
| 13 |
RENAISSANCE TECHNOLOGIES LLC |
114,600 |
833,000 |
0.62% |
|
|
| 14 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
109,764 |
798,000 |
0.59% |
|
|
| 15 |
NORTHERN TRUST CORP |
108,879 |
792,000 |
0.59% |
|
|
| 16 |
STATE STREET CORP |
103,127 |
751,000 |
0.56% |
|
|
| 17 |
DEUTSCHE BANK AG\ |
93,702 |
679,000 |
0.50% |
|
|
| 18 |
GOLDMAN SACHS GROUP INC |
87,861 |
639,000 |
0.48% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
81,957 |
595,000 |
0.44% |
|
|
| 20 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
71,161 |
517,000 |
0.38% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
63,079 |
459,000 |
0.34% |
|
|
| 22 |
TUDOR INVESTMENT CORP ET AL |
55,000 |
400,000 |
0.30% |
|
|
| 23 |
BlackRock Investment Management, LLC |
36,519 |
265,000 |
0.20% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
32,784 |
238,000 |
0.18% |
|
|
| 25 |
Bank of New York Mellon Corp |
29,746 |
216,000 |
0.16% |
|
|
| 26 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
28,665 |
208,000 |
0.15% |
|
|
| 27 |
DAFNA Capital Management LLC |
27,996 |
204,000 |
0.15% |
|
|
| 28 |
ACADIAN ASSET MANAGEMENT LLC |
25,307 |
183,000 |
0.14% |
|
|
| 29 |
Nationwide Fund Advisors |
21,924 |
159,000 |
0.12% |
|
|
| 30 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
21,476 |
156,000 |
0.12% |
|
|
| 31 |
TFS CAPITAL LLC |
20,448 |
149,000 |
0.11% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,600 |
143,000 |
0.11% |
|
|
| 33 |
Connor, Clark & Lunn Investment Management Ltd. |
15,800 |
115,000 |
0.09% |
|
|
| 34 |
BARCLAYS PLC |
15,816 |
115,000 |
0.09% |
|
|
| 35 |
STRS OHIO |
15,900 |
115,000 |
0.09% |
|
|
| 36 |
NEW YORK STATE COMMON RETIREMENT FUND |
14,200 |
103,000 |
0.08% |
|
|
| 37 |
Spark Investment Management LLC |
11,400 |
82,000 |
0.06% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
10,841 |
79,000 |
0.06% |
|
|
| 39 |
PRENTISS SMITH & CO INC |
10,000 |
73,000 |
0.05% |
|
|
| 40 |
PANAGORA ASSET MANAGEMENT INC |
8,057 |
59,000 |
0.04% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,896 |
42,864 |
0.03% |
|
|
| 42 |
Walleye Trading LLC |
4,700 |
34,000 |
0.03% |
|
|
| 43 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
3,651 |
27,000 |
0.02% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
2,718 |
20,000 |
0.01% |
|
|
| 45 |
CITIGROUP INC |
1,032 |
8,000 |
0.01% |
|
|
| 46 |
BlackRock Finance, Inc. |
467 |
3,000 |
0.00% |
|
|
| 47 |
MORGAN STANLEY |
457 |
3,000 |
0.00% |
|
|
| 48 |
BNP PARIBAS FINANCIAL MARKETS |
405 |
2,944 |
0.00% |
|
|
| 49 |
TRUST CO OF VERMONT |
110 |
1,000 |
0.00% |
|
|
| 50 |
BANK OF AMERICA CORP /DE/ |
193 |
1,000 |
0.00% |
|
|
