| 1 |
NEA Management Company, LLC |
8,584,128 |
61,377,000 |
46.64% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
2,762,807 |
19,754,000 |
15.01% |
|
|
| 3 |
BVF INC/IL |
2,426,282 |
17,348,000 |
13.18% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
1,009,979 |
7,221,000 |
5.49% |
|
|
| 5 |
SPHERA FUNDS MANAGEMENT LTD. |
718,080 |
5,134,000 |
3.90% |
|
|
| 6 |
VANGUARD GROUP INC |
409,430 |
2,927,000 |
2.22% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
381,235 |
2,726,000 |
2.07% |
|
|
| 8 |
BlackRock Fund Advisors |
321,658 |
2,300,000 |
1.75% |
|
|
| 9 |
Cormorant Asset Management, LP |
287,031 |
2,052,000 |
1.56% |
|
|
| 10 |
Candriam S.C.A. |
160,000 |
1,144,000 |
0.87% |
|
|
| 11 |
WALL STREET ASSOCIATES |
150,000 |
1,072,000 |
0.81% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
134,100 |
959,000 |
0.73% |
|
|
| 13 |
STATE STREET CORP |
130,951 |
934,000 |
0.71% |
|
|
| 14 |
Invesco Ltd. |
129,429 |
925,000 |
0.70% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
109,764 |
785,000 |
0.60% |
|
|
| 16 |
NORTHERN TRUST CORP |
108,640 |
777,000 |
0.59% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
86,030 |
615,000 |
0.47% |
|
|
| 18 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
70,991 |
508,000 |
0.39% |
|
|
| 19 |
DEUTSCHE BANK AG\ |
69,321 |
495,000 |
0.38% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
61,255 |
438,000 |
0.33% |
|
|
| 21 |
BlackRock Investment Management, LLC |
38,085 |
272,000 |
0.21% |
|
|
| 22 |
Bank of New York Mellon Corp |
34,802 |
249,000 |
0.19% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
31,343 |
224,000 |
0.17% |
|
|
| 24 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
26,565 |
190,000 |
0.14% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
25,076 |
179,000 |
0.14% |
|
|
| 26 |
Nationwide Fund Advisors |
21,924 |
157,000 |
0.12% |
|
|
| 27 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,600 |
141,000 |
0.11% |
|
|
| 28 |
STRS OHIO |
15,300 |
109,000 |
0.08% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
14,375 |
103,000 |
0.08% |
|
|
| 30 |
Connor, Clark & Lunn Investment Management Ltd. |
13,800 |
99,000 |
0.08% |
|
|
| 31 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,974 |
64,000 |
0.05% |
|
|
| 32 |
EMERALD ACQUISITION LTD. |
7,137 |
51,000 |
0.04% |
|
|
| 33 |
BARCLAYS PLC |
6,985 |
50,000 |
0.04% |
|
|
| 34 |
PRENTISS SMITH & CO INC |
7,000 |
50,000 |
0.04% |
|
|
| 35 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,905 |
42,221 |
0.03% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
4,006 |
29,000 |
0.02% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
4,113 |
29,000 |
0.02% |
|
|
| 38 |
BANK OF AMERICA CORP /DE/ |
2,496 |
18,000 |
0.01% |
|
|
| 39 |
MORGAN STANLEY |
2,185 |
16,000 |
0.01% |
|
|
| 40 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
1,300 |
9,000 |
0.01% |
|
|
| 41 |
CITIGROUP INC |
981 |
7,000 |
0.01% |
|
|
| 42 |
BNP PARIBAS FINANCIAL MARKETS |
751 |
5,370 |
0.00% |
|
|
| 43 |
UBS Group AG |
744 |
5,000 |
0.00% |
|
|
| 44 |
ACADIAN ASSET MANAGEMENT LLC |
541 |
4,000 |
0.00% |
|
|
| 45 |
BlackRock Finance, Inc. |
467 |
3,000 |
0.00% |
|
|
| 46 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
351 |
3,000 |
0.00% |
|
|
| 47 |
Tower Research Capital LLC (TRC) |
213 |
2,000 |
0.00% |
|
|
| 48 |
TRUST CO OF VERMONT |
110 |
1,000 |
0.00% |
|
|
