| 1 |
NEA Management Company, LLC |
8,584,128 |
52,363,000 |
45.34% |
|
|
| 2 |
BVF INC/IL |
2,826,282 |
17,240,000 |
14.93% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
2,799,917 |
17,079,000 |
14.79% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
999,979 |
6,100,000 |
5.28% |
|
|
| 5 |
SPHERA FUNDS MANAGEMENT LTD. |
745,796 |
4,549,000 |
3.94% |
|
|
| 6 |
VANGUARD GROUP INC |
424,444 |
2,589,000 |
2.24% |
|
|
| 7 |
BlackRock Fund Advisors |
397,828 |
2,427,000 |
2.10% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
381,235 |
2,326,000 |
2.01% |
|
|
| 9 |
Cormorant Asset Management, LP |
287,031 |
1,751,000 |
1.52% |
|
|
| 10 |
Candriam S.C.A. |
160,000 |
976,000 |
0.85% |
|
|
| 11 |
WALL STREET ASSOCIATES |
150,000 |
915,000 |
0.79% |
|
|
| 12 |
STATE STREET CORP |
134,298 |
819,000 |
0.71% |
|
|
| 13 |
RENAISSANCE TECHNOLOGIES LLC |
117,900 |
719,000 |
0.62% |
|
|
| 14 |
NORTHERN TRUST CORP |
111,367 |
680,000 |
0.59% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
101,577 |
618,000 |
0.54% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
94,992 |
579,000 |
0.50% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
81,764 |
499,000 |
0.43% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
74,894 |
457,000 |
0.40% |
|
|
| 19 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
72,811 |
444,000 |
0.38% |
|
|
| 20 |
MILLENNIUM MANAGEMENT LLC |
50,838 |
310,000 |
0.27% |
|
|
| 21 |
BlackRock Investment Management, LLC |
38,085 |
232,000 |
0.20% |
|
|
| 22 |
Bank of New York Mellon Corp |
35,820 |
219,000 |
0.19% |
|
|
| 23 |
MORGAN STANLEY |
35,076 |
214,000 |
0.19% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
31,343 |
191,000 |
0.17% |
|
|
| 25 |
RUSSELL INVESTMENTS GROUP, LTD. |
28,314 |
172,000 |
0.15% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
24,576 |
150,000 |
0.13% |
|
|
| 27 |
Nationwide Fund Advisors |
21,924 |
134,000 |
0.12% |
|
|
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,600 |
120,000 |
0.10% |
|
|
| 29 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
19,200 |
117,000 |
0.10% |
|
|
| 30 |
Endurant Capital Management LP |
14,500 |
88,000 |
0.08% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
14,375 |
88,000 |
0.08% |
|
|
| 32 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,974 |
55,000 |
0.05% |
|
|
| 33 |
BARCLAYS PLC |
7,104 |
44,000 |
0.04% |
|
|
| 34 |
PRENTISS SMITH & CO INC |
7,000 |
43,000 |
0.04% |
|
|
| 35 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,889 |
36,000 |
0.03% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
4,280 |
26,000 |
0.02% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
4,113 |
25,000 |
0.02% |
|
|
| 38 |
UBS Group AG |
3,142 |
19,000 |
0.02% |
|
|
| 39 |
JPMORGAN CHASE & CO |
3,055 |
19,000 |
0.02% |
|
|
| 40 |
First Personal Financial Services |
1,911 |
12,000 |
0.01% |
|
|
| 41 |
STRS OHIO |
1,800 |
10,000 |
0.01% |
|
|
| 42 |
BANK OF AMERICA CORP /DE/ |
1,642 |
10,000 |
0.01% |
|
|
| 43 |
PERENNIAL ADVISORS, LLC |
1,500 |
9,000 |
0.01% |
|
|
| 44 |
Legal & General Group Plc |
1,315 |
8,000 |
0.01% |
|
|
| 45 |
ROYAL BANK OF CANADA |
685 |
4,000 |
0.00% |
|
|
| 46 |
Tower Research Capital LLC (TRC) |
486 |
3,000 |
0.00% |
|
|
| 47 |
BlackRock Finance, Inc. |
467 |
3,000 |
0.00% |
|
|
| 48 |
MEEDER ASSET MANAGEMENT INC |
233 |
1,000 |
0.00% |
|
|
| 49 |
TRUST CO OF VERMONT |
110 |
1,000 |
0.00% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
159 |
1,000 |
0.00% |
|
|
