| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 6,480,171 | 36,483,000 | 33.77% | ||
| 2 | Abingworth LLP | 6,213,924 | 34,860,000 | 32.26% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,211,372 | 18,080,000 | 16.73% | ||
| 4 | VAN LANSCHOT KEMPEN INVESTMENT MANAGEMENT N.V. | 1,996,253 | 11,239,000 | 10.40% | ||
| 5 | FMR LLC | 376,312 | 2,119,000 | 1.96% | ||
| 6 | FRANKLIN RESOURCES INC | 226,700 | 1,276,000 | 1.18% | ||
| 7 | BLACKROCK ADVISORS LLC | 151,200 | 851,000 | 0.79% | ||
| 8 | Granite Point Capital Management, L.P. | 129,600 | 730,000 | 0.68% | ||
| 9 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,500 | 346,000 | 0.32% | Call | |
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,400 | 239,000 | 0.22% | Put | |
| 11 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 40,200 | 226,000 | 0.21% | ||
| 12 | BlackRock Group LTD | 39,100 | 220,000 | 0.20% | ||
| 13 | CITIGROUP INC | 36,479 | 206,000 | 0.19% | ||
| 14 | Alpine Global Management, LLC | 30,000 | 169,000 | 0.16% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 27,041 | 152,000 | 0.14% | ||
| 16 | MORGAN STANLEY | 22,137 | 125,000 | 0.12% | ||
| 17 | ROYAL BANK OF CANADA | 22,000 | 124,000 | 0.11% | ||
| 18 | OPPENHEIMER & CO INC | 21,000 | 118,000 | 0.11% | ||
| 19 | TFS CAPITAL LLC | 19,363 | 109,000 | 0.10% | ||
| 20 | JANE STREET GROUP, LLC | 16,630 | 94,000 | 0.09% | ||
| 21 | Virtu KCG Holdings LLC | 13,581 | 76,000 | 0.07% | ||
| 22 | CREDIT SUISSE AG/ | 10,801 | 61,000 | 0.06% | ||
| 23 | BARCLAYS PLC | 8,600 | 43,000 | 0.04% | Call | |
| 24 | CITADEL ADVISORS LLC | 6,519 | 37,000 | 0.03% | ||
| 25 | GROUP ONE TRADING LLC | 6,027 | 34,000 | 0.03% | ||
| 26 | UBS AG | 3,900 | 22,000 | 0.02% | Call | |
| 27 | Tower Research Capital LLC (TRC) | 886 | 5,000 | 0.00% | ||
| 28 | WHITTIER TRUST CO | 215 | 1,000 | 0.00% | ||
| 29 | BLUE ARROW CAPITAL MANAGEMENT LLC | 100 | 1,000 | 0.00% | ||
| 30 | UBS AG | 100 | 1,000 | 0.00% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
