| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 6,480,171 | 54,628,000 | 28.82% | ||
| 2 | Abingworth LLP | 6,213,924 | 52,383,000 | 27.63% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,598,459 | 21,905,000 | 11.56% | ||
| 4 | VAN LANSCHOT KEMPEN INVESTMENT MANAGEMENT N.V. | 1,996,253 | 16,828,000 | 8.88% | ||
| 5 | BALYASNY ASSET MANAGEMENT L.P. | 983,950 | 8,295,000 | 4.38% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 864,896 | 7,291,000 | 3.85% | ||
| 7 | FMR LLC | 863,241 | 7,277,000 | 3.84% | ||
| 8 | Proxima Capital Management, LLC | 323,000 | 2,723,000 | 1.44% | ||
| 9 | AXA S.A. | 275,001 | 2,318,000 | 1.22% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 231,500 | 1,952,000 | 1.03% | Put | |
| 11 | MILLENNIUM MANAGEMENT LLC | 231,500 | 1,952,000 | 1.03% | Call | |
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 219,345 | 1,849,000 | 0.98% | ||
| 13 | Granite Point Capital Management, L.P. | 150,000 | 1,265,000 | 0.67% | ||
| 14 | BARCLAYS PLC | 150,000 | 1,200,000 | 0.63% | Put | |
| 15 | BARCLAYS PLC | 150,000 | 1,200,000 | 0.63% | Call | |
| 16 | SECTORAL ASSET MANAGEMENT INC | 94,184 | 794,000 | 0.42% | ||
| 17 | BLACKROCK ADVISORS LLC | 91,200 | 769,000 | 0.41% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 86,700 | 731,000 | 0.39% | Call | |
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,800 | 529,000 | 0.28% | Put | |
| 20 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 51,800 | 437,000 | 0.23% | ||
| 21 | BARCLAYS PLC | 52,747 | 422,000 | 0.22% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,543 | 375,000 | 0.20% | ||
| 23 | UBS AG | 40,400 | 341,000 | 0.18% | Call | |
| 24 | BlackRock Group LTD | 39,100 | 330,000 | 0.17% | ||
| 25 | D. E. Shaw & Co., Inc. | 38,717 | 326,000 | 0.17% | ||
| 26 | MORGAN STANLEY | 31,723 | 268,000 | 0.14% | ||
| 27 | CITIGROUP INC | 29,008 | 245,000 | 0.13% | ||
| 28 | A.R.T. Advisors, LLC | 20,194 | 170,000 | 0.09% | ||
| 29 | GROUP ONE TRADING LLC | 19,073 | 161,000 | 0.08% | ||
| 30 | ROYAL BANK OF CANADA | 17,750 | 149,000 | 0.08% | ||
| 31 | JANE STREET GROUP, LLC | 14,875 | 125,000 | 0.07% | ||
| 32 | Polar Capital LLP | 14,492 | 122,000 | 0.06% | ||
| 33 | OPPENHEIMER & CO INC | 10,000 | 84,000 | 0.04% | ||
| 34 | DEUTSCHE BANK AG\ | 4,811 | 40,000 | 0.02% | ||
| 35 | UBS AG | 4,353 | 37,000 | 0.02% | ||
| 36 | CITADEL ADVISORS LLC | 2,148 | 18,000 | 0.01% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 1,300 | 11,000 | 0.01% | ||
| 38 | Tower Research Capital LLC (TRC) | 485 | 4,000 | 0.00% | ||
| 39 | WHITTIER TRUST CO | 215 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
