| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 6,480,171 | 121,503,000 | 23.67% | ||
| 2 | Abingworth LLP | 6,213,924 | 116,511,000 | 22.70% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,316,434 | 62,183,000 | 12.12% | ||
| 4 | VAN LANSCHOT KEMPEN INVESTMENT MANAGEMENT N.V. | 1,996,253 | 37,430,000 | 7.29% | ||
| 5 | Visium Asset Management, LP | 1,656,698 | 31,065,000 | 6.05% | ||
| 6 | CSS LLC/IL | 917,700 | 17,208,000 | 3.35% | Put | |
| 7 | CHESAPEAKE PARTNERS MANAGEMENT CO INC/MD | 722,333 | 13,544,000 | 2.64% | ||
| 8 | WATER ISLAND CAPITAL LLC | 534,909 | 10,029,544 | 1.95% | ||
| 9 | EQUITEC PROPRIETARY MARKETS, LLC | 502,600 | 9,425,000 | 1.84% | Put | |
| 10 | AQR CAPITAL MANAGEMENT LLC | 489,000 | 9,169,000 | 1.79% | ||
| 11 | Granahan Investment Management, LLC | 359,760 | 6,746,000 | 1.31% | ||
| 12 | Proxima Capital Management, LLC | 323,000 | 6,056,000 | 1.18% | ||
| 13 | GABELLI FUNDS LLC | 310,600 | 5,824,000 | 1.13% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 301,769 | 5,658,000 | 1.10% | ||
| 15 | Granite Point Capital Management, L.P. | 235,000 | 4,406,000 | 0.86% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 229,900 | 4,311,000 | 0.84% | Call | |
| 17 | MILLENNIUM MANAGEMENT LLC | 229,400 | 4,301,000 | 0.84% | Put | |
| 18 | GABELLI & Co INVESTMENT ADVISERS, INC. | 190,645 | 3,575,000 | 0.70% | ||
| 19 | OMERS ADMINISTRATION Corp | 174,545 | 3,273,000 | 0.64% | ||
| 20 | CSS LLC/IL | 163,235 | 3,061,000 | 0.60% | ||
| 21 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 162,825 | 3,053,000 | 0.59% | ||
| 22 | SG Americas Securities, LLC | 149,123 | 2,796,000 | 0.54% | ||
| 23 | BARCLAYS PLC | 150,000 | 2,700,000 | 0.53% | Call | |
| 24 | BARCLAYS PLC | 150,000 | 2,700,000 | 0.53% | Put | |
| 25 | D. E. Shaw & Co., Inc. | 131,221 | 2,460,000 | 0.48% | ||
| 26 | EQUITEC PROPRIETARY MARKETS, LLC | 121,600 | 2,280,000 | 0.44% | Call | |
| 27 | SECTORAL ASSET MANAGEMENT INC | 111,432 | 2,089,000 | 0.41% | ||
| 28 | BARCLAYS PLC | 113,353 | 2,040,000 | 0.40% | ||
| 29 | DEUTSCHE BANK AG\ | 101,255 | 1,898,000 | 0.37% | ||
| 30 | WHITEBOX ADVISORS LLC | 99,343 | 1,863,000 | 0.36% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,700 | 1,663,000 | 0.32% | Put | |
| 32 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 72,450 | 1,358,000 | 0.26% | ||
| 33 | Yakira Capital Management, Inc. | 71,406 | 1,339,000 | 0.26% | SH | |
| 34 | GAMCO INVESTORS, INC. ET AL | 64,000 | 1,200,000 | 0.23% | ||
| 35 | GROUP ONE TRADING LLC | 50,700 | 951,000 | 0.19% | ||
| 36 | Spot Trading L.L.C | 50,000 | 938,000 | 0.18% | Put | |
| 37 | EQUITEC PROPRIETARY MARKETS, LLC | 47,900 | 898,000 | 0.17% | ||
| 38 | K2 PRINCIPAL FUND, L.P. | 44,183 | 828,000 | 0.16% | ||
| 39 | MORGAN STANLEY | 30,740 | 576,000 | 0.11% | ||
| 40 | CITIGROUP INC | 26,445 | 496,000 | 0.10% | ||
| 41 | CSS LLC/IL | 20,000 | 375,000 | 0.07% | Call | |
| 42 | IndexIQ Advisors LLC | 17,738 | 333,000 | 0.06% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,929 | 317,000 | 0.06% | ||
| 44 | BERKLEY W R CORP | 16,782 | 315,000 | 0.06% | ||
| 45 | A.R.T. Advisors, LLC | 16,416 | 307,000 | 0.06% | ||
| 46 | AMERIPRISE FINANCIAL INC | 16,099 | 302,000 | 0.06% | ||
| 47 | Parallax Volatility Advisers, L.P. | 15,000 | 281,000 | 0.05% | Put | |
| 48 | Polar Asset Management Partners Inc. | 15,000 | 281,000 | 0.05% | ||
| 49 | Spot Trading L.L.C | 14,652 | 275,000 | 0.05% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,300 | 231,000 | 0.05% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
