| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 6,480,171 | 81,780,000 | 29.92% | ||
| 2 | Abingworth LLP | 6,213,924 | 78,420,000 | 28.69% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,206,119 | 27,846,000 | 10.19% | ||
| 4 | VAN LANSCHOT KEMPEN INVESTMENT MANAGEMENT N.V. | 1,996,253 | 25,197,000 | 9.22% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 887,553 | 11,203,000 | 4.10% | ||
| 6 | BALYASNY ASSET MANAGEMENT L.P. | 578,111 | 7,297,000 | 2.67% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 387,600 | 4,892,000 | 1.79% | Call | |
| 8 | FMR LLC | 355,812 | 4,490,000 | 1.64% | ||
| 9 | Proxima Capital Management, LLC | 279,700 | 3,530,000 | 1.29% | ||
| 10 | ORBIMED ADVISORS LLC | 264,000 | 3,332,000 | 1.22% | ||
| 11 | AXA S.A. | 248,695 | 3,139,000 | 1.15% | ||
| 12 | FRANKLIN RESOURCES INC | 226,700 | 2,861,000 | 1.05% | ||
| 13 | Ghost Tree Capital, LLC | 175,000 | 2,209,000 | 0.81% | ||
| 14 | BLACKROCK ADVISORS LLC | 150,900 | 1,905,000 | 0.70% | ||
| 15 | Jefferies Group LLC | 140,000 | 1,767,000 | 0.65% | Call | |
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 125,000 | 1,578,000 | 0.58% | ||
| 17 | Jefferies Group LLC | 100,000 | 1,262,000 | 0.46% | Put | |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,800 | 1,259,000 | 0.46% | Put | |
| 19 | Jefferies Group LLC | 89,950 | 1,135,000 | 0.42% | ||
| 20 | Granite Point Capital Management, L.P. | 80,000 | 1,010,000 | 0.37% | ||
| 21 | SECTORAL ASSET MANAGEMENT INC | 75,834 | 957,000 | 0.35% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,509 | 738,000 | 0.27% | ||
| 23 | DRIEHAUS CAPITAL MANAGEMENT LLC | 54,700 | 690,000 | 0.25% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,400 | 636,000 | 0.23% | Call | |
| 25 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 49,200 | 621,000 | 0.23% | ||
| 26 | BlackRock Group LTD | 39,100 | 494,000 | 0.18% | ||
| 27 | MORGAN STANLEY | 35,832 | 452,000 | 0.17% | ||
| 28 | A.R.T. Advisors, LLC | 28,660 | 361,000 | 0.13% | ||
| 29 | CITIGROUP INC | 24,600 | 311,000 | 0.11% | ||
| 30 | BARCLAYS PLC | 24,652 | 296,000 | 0.11% | ||
| 31 | Spot Trading L.L.C | 22,859 | 289,000 | 0.11% | ||
| 32 | TWO SIGMA INVESTMENTS, LP | 18,034 | 228,000 | 0.08% | ||
| 33 | JANE STREET GROUP, LLC | 13,980 | 176,000 | 0.06% | ||
| 34 | ROYAL BANK OF CANADA | 13,650 | 172,000 | 0.06% | ||
| 35 | Geduld E E | 10,000 | 126,000 | 0.05% | ||
| 36 | BANK OF MONTREAL /CAN/ | 10,000 | 126,000 | 0.05% | ||
| 37 | KBC Group NV | 7,067 | 89,000 | 0.03% | ||
| 38 | PEAK6 Group LLC | 7,000 | 88,000 | 0.03% | Put | |
| 39 | BlackRock Institutional Trust Company, N.A. | 6,159 | 78,000 | 0.03% | ||
| 40 | DEUTSCHE BANK AG\ | 4,811 | 60,000 | 0.02% | ||
| 41 | PEAK6 Group LLC | 4,600 | 58,000 | 0.02% | Call | |
| 42 | CITADEL ADVISORS LLC | 4,344 | 55,000 | 0.02% | ||
| 43 | GROUP ONE TRADING LLC | 2,871 | 36,000 | 0.01% | ||
| 44 | UBS AG | 2,300 | 29,000 | 0.01% | Call | |
| 45 | UBS AG | 1,038 | 13,000 | 0.00% | ||
| 46 | WELLS FARGO & COMPANY/MN | 810 | 10,000 | 0.00% | ||
| 47 | PIPER SANDLER & CO. | 800 | 10,000 | 0.00% | ||
| 48 | UBS AG | 700 | 9,000 | 0.00% | Put | |
| 49 | Ground Swell Capital, LLC | 549 | 7,000 | 0.00% | ||
| 50 | Tower Research Capital LLC (TRC) | 585 | 7,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
