| 1 |
BAUPOST GROUP LLC/MA |
3,013,848 |
20,554,000 |
25.22% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
2,162,167 |
14,746,000 |
18.09% |
|
|
| 3 |
EcoR1 Capital, LLC |
1,294,431 |
8,828,000 |
10.83% |
|
|
| 4 |
ARIEL INVESTMENTS, LLC |
1,212,359 |
8,268,000 |
10.14% |
|
|
| 5 |
Sarissa Capital Management LP |
689,091 |
4,700,000 |
5.77% |
|
|
| 6 |
VANGUARD GROUP INC |
370,340 |
2,526,000 |
3.10% |
|
|
| 7 |
Gruss Capital Management LP |
330,000 |
2,251,000 |
2.76% |
|
|
| 8 |
Cormorant Asset Management, LP |
328,497 |
2,240,000 |
2.75% |
|
|
| 9 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
279,204 |
1,904,000 |
2.34% |
|
|
| 10 |
Rock Springs Capital Management LP |
275,000 |
1,876,000 |
2.30% |
|
|
| 11 |
RENAISSANCE TECHNOLOGIES LLC |
177,855 |
1,213,000 |
1.49% |
|
|
| 12 |
Leonard Capital Management, Inc. |
162,348 |
1,107,000 |
1.36% |
|
|
| 13 |
PUTNAM INVESTMENTS LLC |
149,500 |
1,020,000 |
1.25% |
|
|
| 14 |
COLUMBUS CIRCLE INVESTORS |
143,557 |
979,000 |
1.20% |
|
|
| 15 |
NEW YORK STATE COMMON RETIREMENT FUND |
117,461 |
801,000 |
0.98% |
|
|
| 16 |
NORTHERN TRUST CORP |
98,319 |
671,000 |
0.82% |
|
|
| 17 |
Ghost Tree Capital, LLC |
93,500 |
638,000 |
0.78% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
89,664 |
612,000 |
0.75% |
|
|
| 19 |
GOLDMAN SACHS GROUP INC |
84,930 |
579,000 |
0.71% |
|
|
| 20 |
BLACKROCK ADVISORS LLC |
79,096 |
539,000 |
0.66% |
|
|
| 21 |
BANK OF AMERICA CORP /DE/ |
76,319 |
520,000 |
0.64% |
|
|
| 22 |
JOHNSON INVESTMENT COUNSEL INC |
62,700 |
427,000 |
0.52% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
60,629 |
413,000 |
0.51% |
|
|
| 24 |
JACKSON PARK CAPITAL, LLC |
57,000 |
389,000 |
0.48% |
|
|
| 25 |
MILLENNIUM MANAGEMENT LLC |
55,610 |
379,000 |
0.46% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
51,059 |
347,000 |
0.43% |
|
|
| 27 |
ACUTA CAPITAL PARTNERS, LLC |
50,000 |
341,000 |
0.42% |
|
|
| 28 |
Connor, Clark & Lunn Investment Management Ltd. |
49,700 |
339,000 |
0.42% |
|
|
| 29 |
Old West Investment Management, LLC |
42,228 |
287,000 |
0.35% |
|
|
| 30 |
BlackRock Fund Advisors |
34,366 |
234,000 |
0.29% |
|
|
| 31 |
MORGAN STANLEY |
26,434 |
180,000 |
0.22% |
|
|
| 32 |
NORTHERN CAPITAL MANAGEMENT LLC |
25,925 |
177,000 |
0.22% |
|
|
| 33 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
18,888 |
129,000 |
0.16% |
|
|
| 34 |
LPL Financial LLC |
17,743 |
122,000 |
0.15% |
|
|
| 35 |
CREDIT SUISSE AG/ |
16,654 |
114,000 |
0.14% |
|
|
| 36 |
Norman Fields, Gottscho Capital Management, LLC |
16,750 |
114,000 |
0.14% |
|
|
| 37 |
Evanson Asset Management, LLC |
16,545 |
113,000 |
0.14% |
|
|
| 38 |
Paloma Partners Management Co |
16,150 |
110,000 |
0.13% |
|
|
| 39 |
Nine Chapters Capital Management LLC |
16,200 |
110,000 |
0.13% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
15,620 |
107,000 |
0.13% |
|
|
| 41 |
BlackRock Group LTD |
14,850 |
101,000 |
0.12% |
|
|
| 42 |
A.R.T. Advisors, LLC |
11,998 |
81,000 |
0.10% |
|
|
| 43 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
10,969 |
75,000 |
0.09% |
|
|
| 44 |
LMR Partners LLP |
10,246 |
70,000 |
0.09% |
|
|
| 45 |
Alpine Global Management, LLC |
7,413 |
51,000 |
0.06% |
|
|
| 46 |
UBS Group AG |
6,407 |
44,000 |
0.05% |
|
|
| 47 |
Nationwide Fund Advisors |
4,200 |
29,000 |
0.04% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
2,353 |
16,000 |
0.02% |
|
|
| 49 |
BlackRock Investment Management, LLC |
2,258 |
15,000 |
0.02% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
1,537 |
10,000 |
0.01% |
|
|
