| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,200,000 |
4,096,000 |
31.06% |
|
|
| 2 |
Broadfin Capital, LLC |
2,618,296 |
3,351,000 |
25.41% |
|
|
| 3 |
ACUTA CAPITAL PARTNERS, LLC |
2,355,355 |
3,015,000 |
22.87% |
|
|
| 4 |
1492 Capital Management LLC |
514,734 |
659,000 |
5.00% |
|
|
| 5 |
HSBC HOLDINGS PLC |
500,000 |
640,000 |
4.85% |
|
|
| 6 |
VANGUARD GROUP INC |
489,400 |
627,000 |
4.76% |
|
|
| 7 |
Trellus Management Company, LLC |
229,200 |
293,000 |
2.22% |
|
|
| 8 |
DAFNA Capital Management LLC |
88,522 |
113,000 |
0.86% |
|
|
| 9 |
Penbrook Management LLC |
58,000 |
74,000 |
0.56% |
|
|
| 10 |
RENAISSANCE TECHNOLOGIES LLC |
55,800 |
71,000 |
0.54% |
|
|
| 11 |
OAK RIDGE INVESTMENTS LLC |
43,322 |
55,000 |
0.42% |
|
|
| 12 |
SHEPHERD KAPLAN KROCHUK, LLC |
35,848 |
46,000 |
0.35% |
|
|
| 13 |
APIS CAPITAL ADVISORS, LLC |
33,000 |
42,000 |
0.32% |
|
|
| 14 |
TD Capital Management LLC |
29,429 |
38,000 |
0.29% |
|
|
| 15 |
GOLDMAN SACHS GROUP INC |
13,787 |
18,000 |
0.14% |
|
|
| 16 |
BANK OF AMERICA CORP /DE/ |
11,700 |
15,000 |
0.11% |
|
|
| 17 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
10,400 |
13,000 |
0.10% |
|
|
| 18 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
5,285 |
7,000 |
0.05% |
|
|
| 19 |
BlackRock Investment Management, LLC |
4,283 |
5,000 |
0.04% |
|
|
| 20 |
UBS Group AG |
2,353 |
3,000 |
0.02% |
|
|
| 21 |
FIRST NATIONAL BANK SIOUX FALLS |
2,000 |
3,000 |
0.02% |
|
|
| 22 |
Tower Research Capital LLC (TRC) |
818 |
1,000 |
0.01% |
|
|
| 23 |
People's United Financial, Inc. |
1,000 |
1,000 |
0.01% |
|
|
| 24 |
MORGAN STANLEY |
46 |
0 |
0.00% |
|
|
| 25 |
WELLS FARGO & COMPANY/MN |
375 |
0 |
0.00% |
|
|
