| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 9,591,546 | 860,458,000 | 16.33% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 7,751,307 | 695,370,000 | 13.20% | ||
| 3 | AMERIPRISE FINANCIAL INC | 4,257,195 | 381,916,000 | 7.25% | ||
| 4 | VANGUARD GROUP INC | 3,473,563 | 311,613,000 | 5.92% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 3,221,572 | 288,704,000 | 5.48% | ||
| 6 | Capital World Investors | 2,976,977 | 267,065,000 | 5.07% | ||
| 7 | FMR LLC | 2,360,271 | 211,740,000 | 4.02% | ||
| 8 | PRIMECAP MANAGEMENT CO/CA/ | 2,313,039 | 207,503,000 | 3.94% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,659,956 | 148,915,000 | 2.83% | ||
| 10 | FRED ALGER MANAGEMENT, LLC | 1,477,603 | 132,556,000 | 2.52% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,181,100 | 105,956,000 | 2.01% | Put | |
| 12 | STATE STREET CORP | 1,180,473 | 105,912,000 | 2.01% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 779,200 | 69,902,000 | 1.33% | Call | |
| 14 | BB BIOTECH AG | 731,542 | 65,627,000 | 1.25% | ||
| 15 | GOLDMAN SACHS GROUP INC | 711,555 | 63,834,000 | 1.21% | ||
| 16 | CORNERSTONE CAPITAL MANAGEMENT LLC | 707,653 | 63,484,000 | 1.21% | ||
| 17 | FIRST TRUST ADVISORS LP | 642,279 | 57,619,000 | 1.09% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 619,025 | 55,533,000 | 1.05% | ||
| 19 | NORGES BANK | 592,056 | 53,114,000 | 1.01% | ||
| 20 | Point72 Asset Management, L.P. | 574,900 | 51,574,000 | 0.98% | ||
| 21 | MORGAN STANLEY | 548,724 | 49,227,000 | 0.93% | ||
| 22 | MANAGED ACCOUNT ADVISORS LLC | 529,181 | 47,473,000 | 0.90% | ||
| 23 | BlackRock Fund Advisors | 470,203 | 42,182,000 | 0.80% | ||
| 24 | FEDERATED HERMES, INC. | 447,977 | 40,188,000 | 0.76% | ||
| 25 | NORTHERN TRUST CORP | 416,387 | 37,354,000 | 0.71% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 392,486 | 35,210,000 | 0.67% | ||
| 27 | ALLIANCEBERNSTEIN L.P. | 375,962 | 33,728,000 | 0.64% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 347,562 | 31,172,000 | 0.59% | ||
| 29 | RUSSELL FRANK CO/ | 273,360 | 29,424,000 | 0.56% | ||
| 30 | Bank of New York Mellon Corp | 286,827 | 25,731,000 | 0.49% | ||
| 31 | Artal Group S.A. | 270,000 | 24,222,000 | 0.46% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 244,037 | 21,892,000 | 0.42% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 234,834 | 21,067,000 | 0.40% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 228,600 | 20,508,000 | 0.39% | ||
| 35 | DEUTSCHE BANK AG\ | 223,514 | 20,049,000 | 0.38% | ||
| 36 | BlackRock Group LTD | 214,471 | 19,241,000 | 0.37% | ||
| 37 | FRANKLIN RESOURCES INC | 189,600 | 17,009,000 | 0.32% | ||
| 38 | D. E. Shaw & Co., Inc. | 174,500 | 15,654,000 | 0.30% | Put | |
| 39 | VAN ECK ASSOCIATES CORP | 160,267 | 14,378,000 | 0.27% | ||
| 40 | Artal Group S.A. | 150,000 | 13,457,000 | 0.26% | Call | |
| 41 | TD ASSET MANAGEMENT INC | 146,100 | 13,107,000 | 0.25% | ||
| 42 | Sumitomo Mitsui Trust Group, Inc. | 145,332 | 13,038,000 | 0.25% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 137,400 | 12,326,000 | 0.23% | ||
| 44 | CREDIT SUISSE AG/ | 129,388 | 11,607,000 | 0.22% | ||
| 45 | ITHAKA GROUP LLC | 120,112 | 10,775,000 | 0.20% | ||
| 46 | Mitsubishi UFJ Trust & Banking Corp | 119,122 | 10,686,000 | 0.20% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 118,764 | 10,654,000 | 0.20% | ||
| 48 | DAFNA Capital Management LLC | 115,628 | 10,373,000 | 0.20% | ||
| 49 | Parametric Risk Advisors LLC | 112,900 | 10,128,000 | 0.19% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 111,727 | 10,023,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
