| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,886,484 | 1,208,722,000 | 16.40% | ||
| 2 | BAKER BROS. ADVISORS LP | 9,129,231 | 1,116,140,000 | 15.15% | ||
| 3 | AMERIPRISE FINANCIAL INC | 4,968,834 | 607,488,000 | 8.24% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 4,876,934 | 596,267,000 | 8.09% | ||
| 5 | VANGUARD GROUP INC | 3,626,736 | 443,405,000 | 6.02% | ||
| 6 | PRIMECAP MANAGEMENT CO/CA/ | 2,310,539 | 282,486,000 | 3.83% | ||
| 7 | FMR LLC | 1,999,286 | 244,433,000 | 3.32% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,535,553 | 187,737,000 | 2.55% | ||
| 9 | BlackRock Fund Advisors | 1,389,913 | 169,931,000 | 2.31% | ||
| 10 | STATE STREET CORP | 1,139,300 | 139,284,000 | 1.89% | ||
| 11 | Capital World Investors | 756,255 | 127,618,000 | 1.73% | ||
| 12 | FRED ALGER MANAGEMENT, LLC | 945,080 | 115,546,000 | 1.57% | ||
| 13 | FEDERATED HERMES, INC. | 834,276 | 101,999,000 | 1.38% | ||
| 14 | FIRST TRUST ADVISORS LP | 825,428 | 100,917,000 | 1.37% | ||
| 15 | BB BIOTECH AG | 731,542 | 89,438,000 | 1.21% | ||
| 16 | MANAGED ACCOUNT ADVISORS LLC | 659,171 | 80,590,000 | 1.09% | ||
| 17 | NORGES BANK | 583,765 | 71,372,000 | 0.97% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 567,500 | 69,383,000 | 0.94% | Put | |
| 19 | MORGAN STANLEY | 531,722 | 65,009,000 | 0.88% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 446,600 | 54,601,000 | 0.74% | Call | |
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 413,293 | 50,528,000 | 0.69% | ||
| 22 | CORNERSTONE CAPITAL MANAGEMENT LLC | 401,351 | 49,069,000 | 0.67% | ||
| 23 | DEUTSCHE BANK AG\ | 391,713 | 47,887,000 | 0.65% | ||
| 24 | ALLIANCEBERNSTEIN L.P. | 390,779 | 47,777,000 | 0.65% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 375,205 | 45,873,000 | 0.62% | ||
| 26 | NORTHERN TRUST CORP | 358,970 | 43,888,000 | 0.60% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 332,482 | 40,626,000 | 0.55% | ||
| 28 | 1832 Asset Management L.P. | 337,600 | 40,596,000 | 0.55% | ||
| 29 | Parametric Risk Advisors LLC | 300,000 | 36,678,000 | 0.50% | ||
| 30 | Bank of New York Mellon Corp | 268,592 | 32,837,000 | 0.45% | ||
| 31 | GOLDMAN SACHS GROUP INC | 237,099 | 28,987,000 | 0.39% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 173,518 | 28,917,000 | 0.39% | ||
| 33 | RUSSELL FRANK CO/ | 230,219 | 28,219,000 | 0.38% | ||
| 34 | BlackRock Group LTD | 228,116 | 27,889,000 | 0.38% | ||
| 35 | Artal Group S.A. | 225,000 | 27,509,000 | 0.37% | ||
| 36 | Asset Management One Co., Ltd. | 212,418 | 26,286,000 | 0.36% | ||
| 37 | LORD, ABBETT & CO. LLC | 209,870 | 25,659,000 | 0.35% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 205,345 | 25,105,000 | 0.34% | ||
| 39 | TD ASSET MANAGEMENT INC | 205,300 | 25,100,000 | 0.34% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 180,993 | 22,128,000 | 0.30% | ||
| 41 | D. E. Shaw & Co., Inc. | 174,100 | 21,285,000 | 0.29% | Put | |
| 42 | CREDIT SUISSE AG/ | 149,255 | 18,247,000 | 0.25% | ||
| 43 | Sumitomo Mitsui Trust Group, Inc. | 145,798 | 17,872,000 | 0.24% | ||
| 44 | TEACHERS ADVISORS, LLC | 145,958 | 17,845,000 | 0.24% | ||
| 45 | LOS ANGELES CAPITAL MANAGEMENT LLC | 144,402 | 17,655,000 | 0.24% | ||
| 46 | VAN ECK ASSOCIATES CORP | 137,457 | 16,805,000 | 0.23% | ||
| 47 | Mitsubishi UFJ Trust & Banking Corp | 115,606 | 14,134,000 | 0.19% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 113,445 | 13,870,000 | 0.19% | ||
| 49 | DAFNA Capital Management LLC | 110,928 | 13,562,000 | 0.18% | ||
| 50 | MARSHALL WACE, LLP | 108,227 | 13,232,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
