| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,825,892 | 1,153,854,000 | 16.42% | ||
| 2 | BAKER BROS. ADVISORS LP | 9,656,599 | 1,133,974,000 | 16.14% | ||
| 3 | AMERIPRISE FINANCIAL INC | 4,504,353 | 528,947,000 | 7.53% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 3,811,154 | 447,542,000 | 6.37% | ||
| 5 | VANGUARD GROUP INC | 3,520,116 | 413,367,000 | 5.88% | ||
| 6 | Capital World Investors | 2,476,977 | 290,871,000 | 4.14% | ||
| 7 | PRIMECAP MANAGEMENT CO/CA/ | 2,311,039 | 271,385,000 | 3.86% | ||
| 8 | FMR LLC | 2,004,592 | 235,399,000 | 3.35% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,531,739 | 179,872,000 | 2.56% | ||
| 10 | STATE STREET CORP | 1,151,933 | 135,265,000 | 1.93% | ||
| 11 | FRED ALGER MANAGEMENT, LLC | 1,016,483 | 119,365,000 | 1.70% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 863,900 | 101,448,000 | 1.44% | Put | |
| 13 | FEDERATED HERMES, INC. | 824,125 | 96,777,000 | 1.38% | ||
| 14 | BB BIOTECH AG | 731,542 | 85,905,000 | 1.22% | ||
| 15 | FIRST TRUST ADVISORS LP | 720,123 | 84,564,000 | 1.20% | ||
| 16 | CORNERSTONE CAPITAL MANAGEMENT LLC | 691,358 | 81,186,000 | 1.16% | ||
| 17 | MANAGED ACCOUNT ADVISORS LLC | 600,832 | 70,555,000 | 1.00% | ||
| 18 | NORGES BANK | 583,765 | 68,552,000 | 0.98% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 576,800 | 67,734,000 | 0.96% | Call | |
| 20 | MORGAN STANLEY | 560,538 | 65,824,000 | 0.94% | ||
| 21 | GOLDMAN SACHS GROUP INC | 484,631 | 56,910,000 | 0.81% | ||
| 22 | BlackRock Fund Advisors | 478,573 | 56,199,000 | 0.80% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 403,628 | 47,399,000 | 0.67% | ||
| 24 | ALLIANCEBERNSTEIN L.P. | 389,435 | 45,731,000 | 0.65% | ||
| 25 | NORTHERN TRUST CORP | 369,079 | 43,342,000 | 0.62% | ||
| 26 | RUSSELL FRANK CO/ | 347,560 | 40,814,000 | 0.58% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 337,172 | 39,583,000 | 0.56% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 312,062 | 36,645,000 | 0.52% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 272,083 | 31,950,000 | 0.45% | ||
| 30 | Bank of New York Mellon Corp | 270,894 | 31,811,000 | 0.45% | ||
| 31 | DEUTSCHE BANK AG\ | 268,263 | 31,499,000 | 0.45% | ||
| 32 | HWG Holdings LP | 245,344 | 28,811,000 | 0.41% | ||
| 33 | LORD, ABBETT & CO. LLC | 238,618 | 28,021,000 | 0.40% | ||
| 34 | Artal Group S.A. | 225,000 | 26,422,000 | 0.38% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 220,941 | 25,946,000 | 0.37% | ||
| 36 | BlackRock Group LTD | 220,739 | 25,921,000 | 0.37% | ||
| 37 | TD ASSET MANAGEMENT INC | 200,100 | 23,498,000 | 0.33% | ||
| 38 | NOMURA HOLDINGS INC | 180,000 | 20,770,000 | 0.30% | Call | |
| 39 | Asset Management One Co., Ltd. | 169,109 | 20,381,000 | 0.29% | ||
| 40 | Invesco Ltd. | 165,426 | 19,426,000 | 0.28% | ||
| 41 | D. E. Shaw & Co., Inc. | 164,500 | 19,317,000 | 0.27% | Put | |
| 42 | VAN ECK ASSOCIATES CORP | 157,992 | 18,553,000 | 0.26% | ||
| 43 | CREDIT SUISSE AG/ | 148,808 | 17,475,000 | 0.25% | ||
| 44 | Sumitomo Mitsui Trust Group, Inc. | 145,151 | 17,045,000 | 0.24% | ||
| 45 | TEACHERS ADVISORS, LLC | 145,000 | 17,027,000 | 0.24% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 142,175 | 16,696,000 | 0.24% | ||
| 47 | CITADEL ADVISORS LLC | 141,011 | 16,558,000 | 0.24% | ||
| 48 | PANAGORA ASSET MANAGEMENT INC | 135,187 | 15,875,000 | 0.23% | ||
| 49 | COLUMBUS CIRCLE INVESTORS | 132,795 | 15,594,000 | 0.22% | ||
| 50 | ITHAKA GROUP LLC | 114,250 | 13,416,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
