| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 8,737,888 | 875,711,000 | 15.69% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,702,791 | 671,754,000 | 12.04% | ||
| 3 | AMERIPRISE FINANCIAL INC | 3,447,689 | 345,530,000 | 6.19% | ||
| 4 | VANGUARD GROUP INC | 3,400,848 | 340,832,000 | 6.11% | ||
| 5 | FMR LLC | 2,474,565 | 248,001,000 | 4.44% | ||
| 6 | PRIMECAP MANAGEMENT CO/CA/ | 2,380,739 | 238,598,000 | 4.28% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,638,385 | 164,199,000 | 2.94% | ||
| 8 | FRED ALGER MANAGEMENT, LLC | 1,464,803 | 146,802,000 | 2.63% | ||
| 9 | Capital World Investors | 1,414,277 | 141,739,000 | 2.54% | ||
| 10 | GOLDMAN SACHS GROUP INC | 1,307,938 | 131,081,000 | 2.35% | ||
| 11 | STATE STREET CORP | 1,195,057 | 119,757,000 | 2.15% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,067,800 | 107,015,000 | 1.92% | Put | |
| 13 | COLUMBUS CIRCLE INVESTORS | 883,877 | 88,582,000 | 1.59% | ||
| 14 | JANUS HENDERSON INVESTORS US LLC | 826,635 | 82,845,000 | 1.48% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 778,900 | 78,061,000 | 1.40% | Call | |
| 16 | 1832 Asset Management L.P. | 734,818 | 67,222,000 | 1.20% | ||
| 17 | BB BIOTECH AG | 636,542 | 63,794,000 | 1.14% | ||
| 18 | NORGES BANK | 592,056 | 59,336,000 | 1.06% | ||
| 19 | FIRST TRUST ADVISORS LP | 571,154 | 57,241,000 | 1.03% | ||
| 20 | CORNERSTONE CAPITAL MANAGEMENT LLC | 514,635 | 51,577,000 | 0.92% | ||
| 21 | MORGAN STANLEY | 489,106 | 49,018,000 | 0.88% | ||
| 22 | BlackRock Fund Advisors | 479,013 | 48,007,000 | 0.86% | ||
| 23 | NORTHERN TRUST CORP | 458,348 | 45,937,000 | 0.82% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 452,657 | 45,365,000 | 0.81% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 417,906 | 41,882,000 | 0.75% | ||
| 26 | MANAGED ACCOUNT ADVISORS LLC | 411,331 | 41,223,000 | 0.74% | ||
| 27 | FRANKLIN RESOURCES INC | 399,000 | 39,988,000 | 0.72% | ||
| 28 | SAC Capital Advisors LP | 388,523 | 38,938,000 | 0.70% | ||
| 29 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 380,403 | 38,123,000 | 0.68% | ||
| 30 | FEDERATED HERMES, INC. | 373,453 | 37,427,000 | 0.67% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 337,240 | 33,792,000 | 0.61% | ||
| 32 | ALLIANCEBERNSTEIN L.P. | 307,076 | 30,775,000 | 0.55% | ||
| 33 | RUSSELL FRANK CO/ | 319,751 | 30,570,000 | 0.55% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 302,900 | 30,356,000 | 0.54% | Put | |
| 35 | HWG Holdings LP | 302,674 | 30,334,000 | 0.54% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 299,553 | 30,021,000 | 0.54% | ||
| 37 | Bank of New York Mellon Corp | 285,106 | 28,573,000 | 0.51% | ||
| 38 | SCOUT INVESTMENTS, INC. | 264,898 | 26,548,000 | 0.48% | ||
| 39 | GUGGENHEIM CAPITAL LLC | 241,963 | 24,249,000 | 0.43% | ||
| 40 | MILLENNIUM MANAGEMENT LLC | 224,162 | 22,466,000 | 0.40% | ||
| 41 | Artal Group S.A. | 210,000 | 21,046,000 | 0.38% | ||
| 42 | BlackRock Group LTD | 203,950 | 20,440,000 | 0.37% | ||
| 43 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 170,893 | 17,127,000 | 0.31% | ||
| 44 | Sumitomo Mitsui Trust Group, Inc. | 164,662 | 16,502,000 | 0.30% | ||
| 45 | D. E. Shaw & Co., Inc. | 164,500 | 16,486,000 | 0.30% | Put | |
| 46 | JPMORGAN CHASE & CO | 164,246 | 16,460,000 | 0.29% | ||
| 47 | Invesco Ltd. | 162,699 | 16,306,000 | 0.29% | ||
| 48 | VAN ECK ASSOCIATES CORP | 153,765 | 15,410,000 | 0.28% | ||
| 49 | HealthCor Management, L.P. | 150,000 | 15,033,000 | 0.27% | Put | |
| 50 | GSA CAPITAL PARTNERS LLP | 147,782 | 14,811,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
