| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,032,164 | 159,551,000 | 12.65% | ||
| 2 | BAKER BROS. ADVISORS LP | 3,661,082 | 96,836,000 | 7.68% | ||
| 3 | VANGUARD GROUP INC | 3,509,422 | 92,825,000 | 7.36% | ||
| 4 | BlackRock Fund Advisors | 3,352,000 | 88,660,000 | 7.03% | ||
| 5 | SCOPIA CAPITAL MANAGEMENT LP | 2,655,533 | 70,239,000 | 5.57% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,753,191 | 46,371,000 | 3.68% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,665,245 | 44,045,000 | 3.49% | ||
| 8 | STATE STREET CORP | 1,455,471 | 38,494,000 | 3.05% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,360,908 | 35,996,000 | 2.85% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,217,174 | 32,194,000 | 2.55% | ||
| 11 | DIMENSIONAL FUND ADVISORS LP | 1,172,910 | 31,023,000 | 2.46% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,029,410 | 27,228,000 | 2.16% | ||
| 13 | Clearbridge Investments, LLC | 940,847 | 24,885,000 | 1.97% | ||
| 14 | AJO, LP | 631,980 | 16,716,000 | 1.33% | ||
| 15 | D. E. Shaw & Co., Inc. | 545,551 | 14,430,000 | 1.14% | ||
| 16 | Bank of New York Mellon Corp | 544,850 | 14,412,000 | 1.14% | ||
| 17 | NORTHERN TRUST CORP | 528,972 | 13,992,000 | 1.11% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 512,895 | 13,566,000 | 1.08% | ||
| 19 | TWO SIGMA INVESTMENTS, LP | 504,045 | 13,332,000 | 1.06% | ||
| 20 | RA CAPITAL MANAGEMENT, L.P. | 498,159 | 13,176,000 | 1.04% | ||
| 21 | PFM Health Sciences, LP | 478,268 | 12,650,000 | 1.00% | ||
| 22 | MACQUARIE GROUP LTD | 453,133 | 11,985,000 | 0.95% | ||
| 23 | MORGAN STANLEY | 433,237 | 11,459,000 | 0.91% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 395,390 | 10,459,000 | 0.83% | ||
| 25 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 378,017 | 9,999,000 | 0.79% | ||
| 26 | ARMISTICE CAPITAL, LLC | 358,000 | 9,469,000 | 0.75% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 355,981 | 9,415,000 | 0.75% | ||
| 28 | Invesco Ltd. | 351,117 | 9,287,000 | 0.74% | ||
| 29 | Penn Capital Management Company, LLC | 347,157 | 9,182,000 | 0.73% | ||
| 30 | AMERIPRISE FINANCIAL INC | 346,921 | 9,175,000 | 0.73% | ||
| 31 | PRUDENTIAL FINANCIAL INC | 339,652 | 8,984,000 | 0.71% | ||
| 32 | NORGES BANK | 336,873 | 8,910,000 | 0.71% | ||
| 33 | PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 319,162 | 8,442,000 | 0.67% | ||
| 34 | PRINCIPAL FINANCIAL GROUP INC | 313,616 | 8,295,000 | 0.66% | ||
| 35 | TWO SIGMA ADVISERS, LP | 303,896 | 8,038,000 | 0.64% | ||
| 36 | GOLDMAN SACHS GROUP INC | 284,680 | 7,529,000 | 0.60% | ||
| 37 | Spark Investment Management LLC | 268,300 | 7,096,000 | 0.56% | ||
| 38 | HUSSMAN STRATEGIC ADVISORS, INC. | 250,000 | 6,613,000 | 0.52% | ||
| 39 | JENNISON ASSOCIATES LLC | 242,111 | 6,404,000 | 0.51% | ||
| 40 | RUSSELL FRANK CO/ | 234,355 | 6,197,000 | 0.49% | ||
| 41 | TEACHERS ADVISORS, LLC | 212,911 | 5,631,000 | 0.45% | ||
| 42 | THRIVENT FINANCIAL FOR LUTHERANS | 203,860 | 5,392,000 | 0.43% | ||
| 43 | JPMORGAN CHASE & CO | 192,015 | 5,079,000 | 0.40% | ||
| 44 | SENZAR ASSET MANAGEMENT, LLC | 184,902 | 4,890,658 | 0.39% | ||
| 45 | PRICE T ROWE ASSOCIATES INC /MD/ | 172,710 | 4,568,000 | 0.36% | ||
| 46 | BlackRock Investment Management, LLC | 170,198 | 4,502,000 | 0.36% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 167,792 | 4,438,000 | 0.35% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 164,970 | 4,363,000 | 0.35% | ||
| 49 | PANAGORA ASSET MANAGEMENT INC | 164,588 | 4,353,000 | 0.35% | ||
| 50 | NEW YORK STATE COMMON RETIREMENT FUND | 150,431 | 3,979,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
