| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,473,305 | 276,928,000 | 13.28% | ||
| 2 | BAKER BROS. ADVISORS LP | 3,580,112 | 153,157,000 | 7.34% | ||
| 3 | VANGUARD GROUP INC | 3,283,773 | 140,480,000 | 6.74% | ||
| 4 | BlackRock Fund Advisors | 3,190,370 | 136,484,000 | 6.55% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,777,071 | 118,803,000 | 5.70% | ||
| 6 | SCOPIA CAPITAL MANAGEMENT LP | 1,953,423 | 83,567,000 | 4.01% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,788,565 | 76,514,000 | 3.67% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 1,758,036 | 75,209,000 | 3.61% | ||
| 9 | THRIVENT FINANCIAL FOR LUTHERANS | 1,662,310 | 71,114,000 | 3.41% | ||
| 10 | STATE STREET CORP | 1,305,511 | 55,849,000 | 2.68% | ||
| 11 | PFM Health Sciences, LP | 1,287,443 | 55,077,000 | 2.64% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,145,944 | 49,023,000 | 2.35% | ||
| 13 | DIMENSIONAL FUND ADVISORS LP | 1,097,219 | 46,939,000 | 2.25% | ||
| 14 | Clearbridge Investments, LLC | 954,321 | 40,826,000 | 1.96% | ||
| 15 | ORACLE INVESTMENT MANAGEMENT INC | 815,838 | 34,902,000 | 1.67% | ||
| 16 | Bank of New York Mellon Corp | 700,086 | 29,950,000 | 1.44% | ||
| 17 | LOOMIS SAYLES & CO L P | 584,492 | 25,005,000 | 1.20% | ||
| 18 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 548,777 | 23,477,000 | 1.13% | ||
| 19 | STIFEL FINANCIAL CORP | 242,912 | 22,387,000 | 1.07% | ||
| 20 | NORTHERN TRUST CORP | 521,174 | 22,296,000 | 1.07% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 512,064 | 21,906,000 | 1.05% | ||
| 22 | SENZAR ASSET MANAGEMENT, LLC | 504,253 | 21,571,943 | 1.03% | ||
| 23 | Invesco Ltd. | 460,192 | 19,687,000 | 0.94% | ||
| 24 | MACQUARIE GROUP LTD | 416,681 | 17,826,000 | 0.85% | ||
| 25 | Penn Capital Management Company, LLC | 356,170 | 15,237,000 | 0.73% | ||
| 26 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 355,339 | 15,201,000 | 0.73% | ||
| 27 | NORGES BANK | 336,873 | 14,411,000 | 0.69% | ||
| 28 | JENNISON ASSOCIATES LLC | 331,958 | 14,201,000 | 0.68% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 314,997 | 13,475,000 | 0.65% | ||
| 30 | PRINCIPAL FINANCIAL GROUP INC | 291,640 | 12,476,000 | 0.60% | ||
| 31 | GOLDMAN SACHS GROUP INC | 290,000 | 12,406,000 | 0.59% | Put | |
| 32 | PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 263,408 | 11,269,000 | 0.54% | ||
| 33 | JPMORGAN CHASE & CO | 234,005 | 10,011,000 | 0.48% | ||
| 34 | VOYA INVESTMENT MANAGEMENT LLC | 226,378 | 9,685,000 | 0.46% | ||
| 35 | ARMISTICE CAPITAL, LLC | 220,000 | 9,412,000 | 0.45% | ||
| 36 | GOLDMAN SACHS GROUP INC | 214,042 | 9,157,000 | 0.44% | ||
| 37 | AMERIPRISE FINANCIAL INC | 211,099 | 9,032,000 | 0.43% | ||
| 38 | TWO SIGMA INVESTMENTS, LP | 195,872 | 8,379,000 | 0.40% | ||
| 39 | TEACHERS ADVISORS, LLC | 191,211 | 8,180,000 | 0.39% | ||
| 40 | RENAISSANCE TECHNOLOGIES LLC | 175,900 | 7,525,000 | 0.36% | ||
| 41 | BALYASNY ASSET MANAGEMENT L.P. | 173,123 | 7,406,000 | 0.36% | ||
| 42 | D. E. Shaw & Co., Inc. | 171,921 | 7,355,000 | 0.35% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 169,194 | 7,238,000 | 0.35% | ||
| 44 | AMERICAN CENTURY COMPANIES INC | 168,892 | 7,225,000 | 0.35% | ||
| 45 | PRICE T ROWE ASSOCIATES INC /MD/ | 167,410 | 7,162,000 | 0.34% | ||
| 46 | DEUTSCHE BANK AG\ | 165,048 | 7,059,000 | 0.34% | ||
| 47 | BlackRock Investment Management, LLC | 164,304 | 7,029,000 | 0.34% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 159,052 | 6,805,000 | 0.33% | ||
| 49 | PANAGORA ASSET MANAGEMENT INC | 158,780 | 6,793,000 | 0.33% | ||
| 50 | Point72 Asset Management, L.P. | 151,400 | 6,477,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
