| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,796,592 | 121,150,000 | 14.54% | ||
| 2 | Visium Asset Management, LP | 1,890,200 | 60,316,000 | 7.24% | ||
| 3 | Palo Alto Investors LP | 1,614,536 | 51,520,000 | 6.18% | ||
| 4 | Broadfin Capital, LLC | 1,510,775 | 48,209,000 | 5.79% | ||
| 5 | FMR LLC | 1,424,744 | 45,464,000 | 5.46% | ||
| 6 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,231,720 | 39,304,000 | 4.72% | ||
| 7 | BANK OF MONTREAL /CAN/ | 1,172,691 | 37,421,000 | 4.49% | ||
| 8 | BlackRock Fund Advisors | 1,047,733 | 33,433,000 | 4.01% | ||
| 9 | STATE STREET CORP | 995,415 | 31,762,000 | 3.81% | ||
| 10 | PUTNAM INVESTMENTS LLC | 944,412 | 30,136,000 | 3.62% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 891,337 | 28,443,000 | 3.41% | ||
| 12 | VANGUARD GROUP INC | 739,411 | 23,595,000 | 2.83% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 675,454 | 21,554,000 | 2.59% | ||
| 14 | Tourbillon Capital Partners, L.P. | 663,788 | 21,181,000 | 2.54% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 426,120 | 13,597,000 | 1.63% | ||
| 16 | DIMENSIONAL FUND ADVISORS LP | 395,511 | 12,619,000 | 1.51% | ||
| 17 | MORGAN STANLEY | 386,974 | 12,348,000 | 1.48% | ||
| 18 | March Altus Capital Management LP | 338,723 | 10,809,000 | 1.30% | ||
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 327,940 | 10,464,000 | 1.26% | ||
| 20 | AlphaOne Investment Services, LLC | 288,198 | 9,196,000 | 1.10% | ||
| 21 | ALYDAR PARTNERS LLC | 287,400 | 9,171,000 | 1.10% | ||
| 22 | IRONWOOD INVESTMENT MANAGEMENT LLC | 275,472 | 8,790,000 | 1.05% | ||
| 23 | NORTHERN TRUST CORP | 258,256 | 8,241,000 | 0.99% | ||
| 24 | TURNER INVESTMENTS LLC | 225,050 | 7,181,000 | 0.86% | ||
| 25 | State of New Jersey Common Pension Fund D | 211,167 | 6,738,000 | 0.81% | ||
| 26 | D. E. Shaw & Co., Inc. | 207,558 | 6,623,000 | 0.79% | ||
| 27 | TEACHERS ADVISORS, LLC | 197,128 | 6,290,000 | 0.75% | ||
| 28 | Bank of New York Mellon Corp | 160,375 | 5,118,000 | 0.61% | ||
| 29 | ORBIMED ADVISORS LLC | 158,000 | 5,042,000 | 0.61% | ||
| 30 | SPHERA FUNDS MANAGEMENT LTD. | 150,230 | 4,794,000 | 0.58% | ||
| 31 | JPMORGAN CHASE & CO | 142,367 | 4,543,000 | 0.55% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 128,929 | 4,115,000 | 0.49% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 126,722 | 4,043,000 | 0.49% | ||
| 34 | PICTET ASSET MANAGEMENT LTD | 124,700 | 3,979,000 | 0.48% | ||
| 35 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 113,020 | 3,607,000 | 0.43% | ||
| 36 | CATAPULT CAPITAL MANAGEMENT LLC | 105,000 | 3,351,000 | 0.40% | ||
| 37 | J. Goldman & Co LP | 102,500 | 3,271,000 | 0.39% | ||
| 38 | Tourbillon Capital Partners, L.P. | 100,000 | 3,191,000 | 0.38% | Call | |
| 39 | BARCLAYS PLC | 100,200 | 3,106,000 | 0.37% | Put | |
| 40 | GOLDMAN SACHS GROUP INC | 95,723 | 3,055,000 | 0.37% | ||
| 41 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 92,815 | 2,962,000 | 0.36% | ||
| 42 | DEUTSCHE BANK AG\ | 91,147 | 2,906,000 | 0.35% | ||
| 43 | ROYAL BANK OF CANADA | 88,666 | 2,829,000 | 0.34% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 88,109 | 2,812,000 | 0.34% | ||
| 45 | Informed Momentum Co LLC | 87,866 | 2,804,000 | 0.34% | ||
| 46 | BARCLAYS PLC | 85,480 | 2,649,000 | 0.32% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 82,200 | 2,623,000 | 0.31% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 79,000 | 2,521,000 | 0.30% | ||
| 49 | NORGES BANK | 76,824 | 2,451,000 | 0.29% | ||
| 50 | BlackRock Investment Management, LLC | 67,178 | 2,144,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
