| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,526,011 | 247,392,000 | 11.35% | ||
| 2 | Palo Alto Investors LP | 2,187,041 | 119,544,000 | 5.48% | ||
| 3 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,900,000 | 103,854,000 | 4.76% | ||
| 4 | WELLS FARGO & COMPANY/MN | 1,666,501 | 91,092,000 | 4.18% | ||
| 5 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,463,390 | 79,989,000 | 3.67% | ||
| 6 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,453,148 | 79,429,069 | 3.64% | ||
| 7 | PUTNAM INVESTMENTS LLC | 1,236,417 | 67,583,000 | 3.10% | ||
| 8 | Camber Capital Management LP | 1,018,246 | 55,657,000 | 2.55% | ||
| 9 | BlackRock Fund Advisors | 1,014,092 | 55,430,000 | 2.54% | ||
| 10 | Invesco Ltd. | 1,001,125 | 54,721,000 | 2.51% | ||
| 11 | VANGUARD GROUP INC | 977,223 | 53,414,000 | 2.45% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 909,205 | 49,697,000 | 2.28% | ||
| 13 | D. E. Shaw & Co., Inc. | 829,790 | 45,356,000 | 2.08% | ||
| 14 | STATE STREET CORP | 798,423 | 43,643,000 | 2.00% | ||
| 15 | PointState Capital LP | 750,000 | 40,995,000 | 1.88% | ||
| 16 | CAMBIAR INVESTORS LLC | 733,918 | 40,116,000 | 1.84% | ||
| 17 | EATON VANCE MANAGEMENT | 709,112 | 38,760,000 | 1.78% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 619,142 | 33,842,000 | 1.55% | ||
| 19 | GLENMEDE TRUST CO NA | 618,639 | 33,814,000 | 1.55% | ||
| 20 | JANUS HENDERSON INVESTORS US LLC | 607,049 | 33,181,000 | 1.52% | ||
| 21 | AMERICAN CENTURY COMPANIES INC | 522,752 | 28,574,000 | 1.31% | ||
| 22 | CAPITAL GROWTH MANAGEMENT LP | 522,000 | 28,533,000 | 1.31% | ||
| 23 | Century Capital Management, LLC | 502,079 | 27,444,000 | 1.26% | ||
| 24 | FRONTIER CAPITAL MANAGEMENT CO LLC | 482,970 | 26,399,000 | 1.21% | ||
| 25 | VAUGHAN NELSON INVESTMENT MANAGEMENT, L.P. | 477,800 | 26,116,000 | 1.20% | ||
| 26 | Allianz Asset Management GmbH | 465,147 | 25,425,000 | 1.17% | ||
| 27 | EverPoint Asset Management, LLC | 455,000 | 24,870,000 | 1.14% | ||
| 28 | PRICE T ROWE ASSOCIATES INC /MD/ | 437,270 | 23,901,000 | 1.10% | ||
| 29 | Greywolf Capital Management LP | 431,552 | 23,320,000 | 1.07% | ||
| 30 | BANK OF MONTREAL /CAN/ | 418,664 | 22,885,000 | 1.05% | ||
| 31 | DIMENSIONAL FUND ADVISORS LP | 394,713 | 21,576,000 | 0.99% | ||
| 32 | Krensavage Asset Management, LLC | 341,091 | 18,644,000 | 0.86% | ||
| 33 | NORTHERN TRUST CORP | 288,265 | 15,756,000 | 0.72% | ||
| 34 | NEXT CENTURY GROWTH INVESTORS LLC | 284,488 | 15,550,000 | 0.71% | ||
| 35 | CASTLEARK MANAGEMENT LLC | 278,213 | 15,207,000 | 0.70% | ||
| 36 | ORBIMED ADVISORS LLC | 275,000 | 15,032,000 | 0.69% | ||
| 37 | Silver Point Capital L.P. | 269,700 | 14,742,000 | 0.68% | ||
| 38 | COLUMBUS CIRCLE INVESTORS | 268,091 | 14,654,000 | 0.67% | ||
| 39 | MARSHALL WACE, LLP | 264,411 | 14,453,000 | 0.66% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 247,039 | 13,503,000 | 0.62% | ||
| 41 | IRONWOOD INVESTMENT MANAGEMENT LLC | 246,186 | 13,457,000 | 0.62% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 221,739 | 12,120,000 | 0.56% | ||
| 43 | JPMORGAN CHASE & CO | 216,789 | 11,850,000 | 0.54% | ||
| 44 | State of New Jersey Common Pension Fund D | 211,167 | 11,542,000 | 0.53% | ||
| 45 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 209,017 | 11,425,000 | 0.52% | ||
| 46 | SPHERA FUNDS MANAGEMENT LTD. | 200,230 | 10,945,000 | 0.50% | ||
| 47 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 196,000 | 10,713,000 | 0.49% | ||
| 48 | WELLINGTON MANAGEMENT GROUP LLP | 192,626 | 10,529,000 | 0.48% | ||
| 49 | Opaleye Management Inc. | 190,000 | 10,385,000 | 0.48% | ||
| 50 | GEODE CAPITAL MANAGEMENT, LLC | 172,968 | 9,453,000 | 0.43% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
