| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,796,592 | 78,665,000 | 15.04% | ||
| 2 | Visium Asset Management, LP | 2,070,870 | 42,908,000 | 8.20% | ||
| 3 | BANK OF MONTREAL /CAN/ | 1,999,631 | 41,433,000 | 7.92% | ||
| 4 | Broadfin Capital, LLC | 1,960,775 | 40,627,000 | 7.77% | ||
| 5 | Palo Alto Investors LP | 1,614,536 | 33,453,000 | 6.40% | ||
| 6 | FMR LLC | 1,143,873 | 23,701,000 | 4.53% | ||
| 7 | STATE STREET CORP | 1,119,465 | 23,196,000 | 4.43% | ||
| 8 | BlackRock Fund Advisors | 1,091,823 | 22,623,000 | 4.33% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 999,339 | 20,706,000 | 3.96% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 835,271 | 17,307,000 | 3.31% | ||
| 11 | VANGUARD GROUP INC | 727,158 | 15,067,000 | 2.88% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 654,500 | 13,561,000 | 2.59% | ||
| 13 | MORGAN STANLEY | 644,293 | 13,349,000 | 2.55% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 425,220 | 8,811,000 | 1.68% | ||
| 15 | DIMENSIONAL FUND ADVISORS LP | 389,980 | 8,080,000 | 1.54% | ||
| 16 | WELLINGTON MANAGEMENT GROUP LLP | 326,060 | 6,756,000 | 1.29% | ||
| 17 | IRONWOOD INVESTMENT MANAGEMENT LLC | 296,458 | 6,143,000 | 1.17% | ||
| 18 | NORTHERN TRUST CORP | 268,792 | 5,569,000 | 1.06% | ||
| 19 | JPMORGAN CHASE & CO | 242,505 | 5,025,000 | 0.96% | ||
| 20 | D. E. Shaw & Co., Inc. | 216,792 | 4,492,000 | 0.86% | ||
| 21 | State of New Jersey Common Pension Fund D | 211,167 | 4,375,000 | 0.84% | ||
| 22 | TEACHERS ADVISORS, LLC | 197,128 | 4,084,000 | 0.78% | ||
| 23 | NORGES BANK | 187,368 | 3,882,000 | 0.74% | ||
| 24 | ROYAL BANK OF CANADA | 160,921 | 3,334,000 | 0.64% | ||
| 25 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 150,900 | 3,126,000 | 0.60% | ||
| 26 | BBT Capital Management, LLC | 150,000 | 3,108,000 | 0.59% | ||
| 27 | March Altus Capital Management LP | 146,418 | 3,034,000 | 0.58% | ||
| 28 | TURNER INVESTMENTS LLC | 144,810 | 3,000,000 | 0.57% | ||
| 29 | J. Goldman & Co LP | 140,000 | 2,901,000 | 0.55% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 138,168 | 2,863,000 | 0.55% | ||
| 31 | PUTNAM INVESTMENTS LLC | 130,839 | 2,711,000 | 0.52% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 129,060 | 2,674,000 | 0.51% | ||
| 33 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 125,760 | 2,606,000 | 0.50% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 124,509 | 2,579,000 | 0.49% | ||
| 35 | BARCLAYS PLC | 120,834 | 2,417,000 | 0.46% | ||
| 36 | Bank of New York Mellon Corp | 116,056 | 2,405,000 | 0.46% | ||
| 37 | Ghost Tree Capital, LLC | 100,000 | 2,072,000 | 0.40% | ||
| 38 | J. Goldman & Co LP | 100,000 | 2,072,000 | 0.40% | Call | |
| 39 | AlphaOne Investment Services, LLC | 97,448 | 2,019,000 | 0.39% | ||
| 40 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 96,495 | 1,999,000 | 0.38% | ||
| 41 | DEUTSCHE BANK AG\ | 93,029 | 1,926,000 | 0.37% | ||
| 42 | J. Goldman & Co LP | 90,000 | 1,865,000 | 0.36% | Put | |
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 87,100 | 1,805,000 | 0.35% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 79,000 | 1,637,000 | 0.31% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 70,931 | 1,470,000 | 0.28% | ||
| 46 | BlackRock Investment Management, LLC | 66,573 | 1,379,000 | 0.26% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 63,323 | 1,312,000 | 0.25% | ||
| 48 | GOLDMAN SACHS GROUP INC | 60,275 | 1,249,000 | 0.24% | ||
| 49 | Tamarack Capital Management, LLC | 64,080 | 1,222,000 | 0.23% | ||
| 50 | CONTINENTAL ADVISORS LLC | 57,438 | 1,190,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
