| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,796,592 | 161,810,000 | 11.88% | ||
| 2 | Palo Alto Investors LP | 1,994,200 | 84,993,000 | 6.24% | ||
| 3 | FMR LLC | 1,298,744 | 55,352,000 | 4.06% | ||
| 4 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,236,690 | 52,708,000 | 3.87% | ||
| 5 | PUTNAM INVESTMENTS LLC | 1,098,762 | 46,829,000 | 3.44% | ||
| 6 | BlackRock Fund Advisors | 1,021,882 | 43,553,000 | 3.20% | ||
| 7 | Camber Capital Management LP | 1,000,000 | 42,620,000 | 3.13% | ||
| 8 | WELLS FARGO & COMPANY/MN | 987,383 | 42,083,000 | 3.09% | ||
| 9 | BANK OF MONTREAL /CAN/ | 932,591 | 39,747,000 | 2.92% | ||
| 10 | Greywolf Capital Management LP | 863,105 | 35,907,000 | 2.64% | ||
| 11 | STATE STREET CORP | 772,826 | 32,936,000 | 2.42% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 753,386 | 32,109,000 | 2.36% | ||
| 13 | VANGUARD GROUP INC | 726,465 | 30,961,000 | 2.27% | ||
| 14 | Invesco Ltd. | 661,331 | 28,186,000 | 2.07% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 624,440 | 26,614,000 | 1.95% | ||
| 16 | Broadfin Capital, LLC | 573,530 | 24,444,000 | 1.79% | ||
| 17 | D. E. Shaw & Co., Inc. | 571,717 | 24,366,000 | 1.79% | ||
| 18 | VAUGHAN NELSON INVESTMENT MANAGEMENT, L.P. | 567,425 | 24,183,000 | 1.78% | ||
| 19 | ALYDAR PARTNERS LLC | 542,903 | 23,139,000 | 1.70% | ||
| 20 | CAPITAL GROWTH MANAGEMENT LP | 522,000 | 22,248,000 | 1.63% | ||
| 21 | Century Capital Management, LLC | 518,276 | 22,089,000 | 1.62% | ||
| 22 | ORBIMED ADVISORS LLC | 469,000 | 19,989,000 | 1.47% | ||
| 23 | Silver Point Capital L.P. | 436,000 | 18,582,000 | 1.36% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 432,970 | 18,453,000 | 1.35% | ||
| 25 | Allianz Asset Management GmbH | 404,948 | 17,259,000 | 1.27% | ||
| 26 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 418,033 | 17,178,000 | 1.26% | ||
| 27 | DIMENSIONAL FUND ADVISORS LP | 395,511 | 16,857,000 | 1.24% | ||
| 28 | Krensavage Asset Management, LLC | 349,042 | 14,876,000 | 1.09% | ||
| 29 | GLENMEDE TRUST CO NA | 310,895 | 13,248,000 | 0.97% | ||
| 30 | PointState Capital LP | 310,000 | 13,212,000 | 0.97% | ||
| 31 | MORGAN STANLEY | 309,963 | 13,211,000 | 0.97% | ||
| 32 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 306,374 | 13,057,660 | 0.96% | ||
| 33 | CASTLEARK MANAGEMENT LLC | 293,913 | 12,527,000 | 0.92% | ||
| 34 | IRONWOOD INVESTMENT MANAGEMENT LLC | 262,430 | 11,185,000 | 0.82% | ||
| 35 | NORTHERN TRUST CORP | 255,352 | 10,883,000 | 0.80% | ||
| 36 | Tourbillon Capital Partners, L.P. | 249,600 | 10,638,000 | 0.78% | ||
| 37 | WELLINGTON MANAGEMENT GROUP LLP | 248,861 | 10,606,000 | 0.78% | ||
| 38 | DRIEHAUS CAPITAL MANAGEMENT LLC | 244,184 | 10,407,000 | 0.76% | ||
| 39 | MARSHALL WACE, LLP | 226,744 | 9,664,000 | 0.71% | ||
| 40 | State of New Jersey Common Pension Fund D | 211,167 | 9,000,000 | 0.66% | ||
| 41 | TEACHERS ADVISORS, LLC | 197,084 | 8,400,000 | 0.62% | ||
| 42 | A.R.T. Advisors, LLC | 171,240 | 7,298,000 | 0.54% | ||
| 43 | AlphaOne Investment Services, LLC | 161,497 | 6,883,000 | 0.51% | ||
| 44 | QS Investors, LLC | 154,100 | 6,568,000 | 0.48% | ||
| 45 | Bank of New York Mellon Corp | 139,017 | 5,925,000 | 0.44% | ||
| 46 | PICTET ASSET MANAGEMENT LTD | 131,200 | 5,592,000 | 0.41% | ||
| 47 | GEODE CAPITAL MANAGEMENT, LLC | 129,855 | 5,533,000 | 0.41% | ||
| 48 | PINNACLE ASSOCIATES LTD | 129,530 | 5,521,000 | 0.41% | ||
| 49 | SPHERA FUNDS MANAGEMENT LTD. | 125,230 | 5,337,000 | 0.39% | ||
| 50 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 123,900 | 5,280,000 | 0.39% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
