| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JPMORGAN CHASE & CO | 2,498,382 | 15,265,000 | 19.72% | ||
| 2 | HealthCor Management, L.P. | 1,150,000 | 7,027,000 | 9.08% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,106,910 | 6,763,000 | 8.74% | ||
| 4 | DAFNA Capital Management LLC | 729,781 | 4,459,000 | 5.76% | ||
| 5 | BLACKROCK ADVISORS LLC | 709,694 | 4,336,000 | 5.60% | ||
| 6 | Broadfin Capital, LLC | 636,700 | 3,890,000 | 5.02% | ||
| 7 | Visium Asset Management, LP | 600,000 | 3,666,000 | 4.74% | ||
| 8 | BVF INC/IL | 435,900 | 2,663,000 | 3.44% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 415,000 | 2,536,000 | 3.28% | ||
| 10 | RENAISSANCE TECHNOLOGIES LLC | 320,905 | 1,961,000 | 2.53% | ||
| 11 | GABELLI & Co INVESTMENT ADVISERS, INC. | 312,068 | 1,907,000 | 2.46% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 294,311 | 1,798,000 | 2.32% | ||
| 13 | Healthcare Value Capital, LLC | 245,507 | 1,500,000 | 1.94% | ||
| 14 | TFS CAPITAL LLC | 239,068 | 1,461,000 | 1.89% | ||
| 15 | MORGAN STANLEY | 173,404 | 1,061,000 | 1.37% | ||
| 16 | 683 Capital Management, LLC | 172,282 | 1,053,000 | 1.36% | ||
| 17 | DIMENSIONAL FUND ADVISORS LP | 171,289 | 1,047,000 | 1.35% | ||
| 18 | DEUTSCHE BANK AG\ | 167,338 | 1,022,000 | 1.32% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 159,893 | 976,000 | 1.26% | ||
| 20 | BlackRock Group LTD | 158,400 | 968,000 | 1.25% | ||
| 21 | TOWERVIEW LLC | 140,000 | 855,000 | 1.10% | ||
| 22 | FMR LLC | 135,000 | 825,000 | 1.07% | ||
| 23 | BlackRock Finance, Inc. | 132,900 | 812,000 | 1.05% | ||
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 119,699 | 731,000 | 0.94% | ||
| 25 | BAILARD, INC. | 115,000 | 703,000 | 0.91% | ||
| 26 | VANGUARD GROUP INC | 104,220 | 637,000 | 0.82% | ||
| 27 | BlackRock Fund Advisors | 91,407 | 558,000 | 0.72% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,880 | 555,000 | 0.72% | ||
| 29 | Dominick & Dominick LLC | 88,089 | 538,000 | 0.69% | ||
| 30 | UBS AG | 84,223 | 515,000 | 0.67% | ||
| 31 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 76,770 | 469,000 | 0.61% | ||
| 32 | CITADEL ADVISORS LLC | 71,749 | 438,000 | 0.57% | ||
| 33 | GOLDMAN SACHS GROUP INC | 69,808 | 427,000 | 0.55% | ||
| 34 | NORTHERN TRUST CORP | 67,150 | 410,000 | 0.53% | ||
| 35 | PANAGORA ASSET MANAGEMENT INC | 60,502 | 370,000 | 0.48% | ||
| 36 | SHEPHERD KAPLAN KROCHUK, LLC | 59,911 | 366,000 | 0.47% | ||
| 37 | CREDIT SUISSE AG/ | 54,088 | 330,000 | 0.43% | ||
| 38 | Spark Investment Management LLC | 43,800 | 267,000 | 0.34% | ||
| 39 | BlueCrest Capital Management LLP | 40,700 | 249,000 | 0.32% | ||
| 40 | SOROS FUND MANAGEMENT LLC | 39,500 | 241,000 | 0.31% | ||
| 41 | JANE STREET GROUP, LLC | 39,134 | 239,000 | 0.31% | ||
| 42 | LMR Partners LLP | 29,919 | 182,000 | 0.24% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,700 | 175,000 | 0.23% | Put | |
| 44 | STATE STREET CORP | 28,473 | 174,000 | 0.22% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,016 | 159,000 | 0.21% | ||
| 46 | GABELLI FUNDS LLC | 21,361 | 131,000 | 0.17% | ||
| 47 | Connor, Clark & Lunn Investment Management Ltd. | 19,200 | 129,000 | 0.17% | ||
| 48 | GSA CAPITAL PARTNERS LLP | 18,100 | 111,000 | 0.14% | ||
| 49 | WELLS FARGO & COMPANY/MN | 16,420 | 100,000 | 0.13% | ||
| 50 | NATIXIS | 15,700 | 96,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
