| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clearbridge Investments, LLC | 14,428,856 | 55,840,000 | 22.32% | ||
| 2 | ORBIMED ADVISORS LLC | 6,095,647 | 23,590,000 | 9.43% | ||
| 3 | BlackRock Finance, Inc. | 5,368,099 | 20,774,000 | 8.31% | ||
| 4 | VANGUARD GROUP INC | 4,110,431 | 15,907,000 | 6.36% | ||
| 5 | Redmile Group, LLC | 3,984,734 | 15,421,000 | 6.17% | ||
| 6 | PRIMECAP MANAGEMENT CO/CA/ | 3,966,000 | 15,348,000 | 6.14% | ||
| 7 | BAKER BROS. ADVISORS LP | 3,015,353 | 11,669,000 | 4.67% | ||
| 8 | DEUTSCHE BANK AG\ | 1,765,021 | 6,829,000 | 2.73% | ||
| 9 | WELLS FARGO & COMPANY/MN | 1,620,279 | 6,270,000 | 2.51% | ||
| 10 | STATE STREET CORP | 1,598,707 | 6,185,000 | 2.47% | ||
| 11 | NORGES BANK | 1,530,772 | 5,924,000 | 2.37% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 1,477,946 | 5,720,000 | 2.29% | ||
| 13 | PANAGORA ASSET MANAGEMENT INC | 1,471,763 | 5,696,000 | 2.28% | ||
| 14 | BANK OF AMERICA CORP /DE/ | 1,339,518 | 5,183,000 | 2.07% | ||
| 15 | MORGAN STANLEY | 1,198,593 | 4,640,000 | 1.86% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 1,106,695 | 4,283,000 | 1.71% | ||
| 17 | NORTHERN TRUST CORP | 1,068,820 | 4,136,000 | 1.65% | ||
| 18 | FMR LLC | 802,029 | 3,104,000 | 1.24% | ||
| 19 | MACQUARIE GROUP LTD | 700,000 | 2,709,000 | 1.08% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 678,343 | 2,625,000 | 1.05% | ||
| 21 | RAYMOND JAMES & ASSOCIATES | 628,236 | 2,431,000 | 0.97% | ||
| 22 | GOLDMAN SACHS GROUP INC | 588,544 | 2,277,000 | 0.91% | ||
| 23 | D. E. Shaw & Co., Inc. | 484,908 | 1,877,000 | 0.75% | ||
| 24 | Bank of New York Mellon Corp | 438,917 | 1,698,000 | 0.68% | ||
| 25 | AMERIPRISE FINANCIAL INC | 394,770 | 1,528,000 | 0.61% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 329,979 | 1,278,000 | 0.51% | ||
| 27 | NATIXIS ADVISORS, LLC | 300,599 | 1,163,000 | 0.46% | ||
| 28 | KBC Group NV | 299,613 | 1,160,000 | 0.46% | ||
| 29 | Fisher Asset Management, LLC | 253,676 | 982,000 | 0.39% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 244,602 | 947,000 | 0.38% | ||
| 31 | TEACHERS ADVISORS, LLC | 189,543 | 734,000 | 0.29% | ||
| 32 | JPMORGAN CHASE & CO | 187,230 | 725,000 | 0.29% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 175,400 | 679,000 | 0.27% | Put | |
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 165,950 | 642,000 | 0.26% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 118,264 | 458,000 | 0.18% | ||
| 36 | TWIN FOCUS CAPITAL PARTNERS, LLC | 113,216 | 438,000 | 0.18% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 111,500 | 432,000 | 0.17% | ||
| 38 | D.A. DAVIDSON & CO. | 105,690 | 409,000 | 0.16% | ||
| 39 | CITIGROUP INC | 103,391 | 400,000 | 0.16% | ||
| 40 | RHUMBLINE ADVISERS | 101,943 | 395,000 | 0.16% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,600 | 385,000 | 0.15% | Call | |
| 42 | STIFEL FINANCIAL CORP | 103,815 | 382,000 | 0.15% | ||
| 43 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 93,560 | 362,000 | 0.14% | ||
| 44 | GSA CAPITAL PARTNERS LLP | 85,526 | 331,000 | 0.13% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 84,301 | 326,000 | 0.13% | ||
| 46 | CREDIT SUISSE AG/ | 73,568 | 284,000 | 0.11% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,965 | 279,000 | 0.11% | ||
| 48 | Nuveen Asset Management, LLC | 68,928 | 267,000 | 0.11% | ||
| 49 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 68,097 | 263,535 | 0.11% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 66,517 | 257,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
