| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,398,491 | 111,335,000 | 17.57% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,870,652 | 61,283,000 | 9.67% | ||
| 3 | Palo Alto Investors LP | 1,102,181 | 36,107,000 | 5.70% | ||
| 4 | PFM Health Sciences, LP | 978,752 | 32,064,000 | 5.06% | ||
| 5 | BlackRock Fund Advisors | 880,896 | 28,858,000 | 4.56% | ||
| 6 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 863,355 | 28,284,000 | 4.46% | ||
| 7 | WADDELL & REED FINANCIAL INC | 740,412 | 24,256,000 | 3.83% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | 22,932,000 | 3.62% | ||
| 9 | STATE STREET CORP | 661,370 | 21,664,000 | 3.42% | ||
| 10 | Pentwater Capital Management LP | 619,400 | 20,292,000 | 3.20% | ||
| 11 | KORNITZER CAPITAL MANAGEMENT INC /KS | 559,075 | 18,315,000 | 2.89% | ||
| 12 | Capital World Investors | 547,300 | 17,930,000 | 2.83% | ||
| 13 | Polar Capital LLP | 479,967 | 15,724,000 | 2.48% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 479,311 | 15,702,000 | 2.48% | ||
| 15 | VANGUARD GROUP INC | 469,413 | 15,377,000 | 2.43% | ||
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 331,213 | 10,851,000 | 1.71% | ||
| 17 | BAKER BROS. ADVISORS LP | 311,255 | 10,197,000 | 1.61% | ||
| 18 | Bank of New York Mellon Corp | 301,272 | 9,868,000 | 1.56% | ||
| 19 | RS INVESTMENT MANAGEMENT CO LLC | 289,881 | 9,497,000 | 1.50% | ||
| 20 | Redmile Group, LLC | 281,479 | 9,221,000 | 1.46% | ||
| 21 | NORTHERN TRUST CORP | 198,662 | 6,508,000 | 1.03% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 185,835 | 6,088,000 | 0.96% | ||
| 23 | REGENTATLANTIC CAPITAL LLC | 176,454 | 5,781,000 | 0.91% | ||
| 24 | ALTRINSIC GLOBAL ADVISORS LLC | 158,154 | 5,181,000 | 0.82% | ||
| 25 | Hutchin Hill Capital, LP | 148,900 | 4,878,000 | 0.77% | ||
| 26 | Aureus Asset Management, LLC | 139,092 | 4,557,000 | 0.72% | ||
| 27 | JPMORGAN CHASE & CO | 131,261 | 4,300,000 | 0.68% | ||
| 28 | C WorldWide Group Holding A/S | 127,100 | 4,236,000 | 0.67% | ||
| 29 | Tekla Capital Management LLC | 111,433 | 3,651,000 | 0.58% | ||
| 30 | Allianz Asset Management GmbH | 106,670 | 3,495,000 | 0.55% | ||
| 31 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 99,585 | 3,262,000 | 0.51% | ||
| 32 | LORD, ABBETT & CO. LLC | 91,960 | 3,013,000 | 0.48% | ||
| 33 | ASCEND CAPITAL, LLC | 88,470 | 2,899,000 | 0.46% | ||
| 34 | BNP Paribas Asset Management Holding S.A. | 87,117 | 2,854,000 | 0.45% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 86,893 | 2,846,000 | 0.45% | ||
| 36 | GUGGENHEIM CAPITAL LLC | 69,856 | 2,288,000 | 0.36% | ||
| 37 | RICE HALL JAMES & ASSOCIATES, LLC | 66,486 | 2,178,000 | 0.34% | ||
| 38 | SENZAR ASSET MANAGEMENT, LLC | 66,300 | 2,172,000 | 0.34% | ||
| 39 | EAGLE ASSET MANAGEMENT INC | 65,732 | 2,153,000 | 0.34% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 65,063 | 2,131,000 | 0.34% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,100 | 1,805,000 | 0.28% | Put | |
| 42 | Amici Capital, LLC | 53,700 | 1,759,000 | 0.28% | ||
| 43 | Senvest Management, LLC | 52,787 | 1,729,000 | 0.27% | ||
| 44 | BlackRock Investment Management, LLC | 50,609 | 1,658,000 | 0.26% | ||
| 45 | BBT Capital Management, LLC | 50,000 | 1,638,000 | 0.26% | ||
| 46 | DEUTSCHE BANK AG\ | 48,430 | 1,585,000 | 0.25% | ||
| 47 | AlpInvest Partners B.V. | 48,087 | 1,575,000 | 0.25% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,967 | 1,539,000 | 0.24% | ||
| 49 | MANAGED ACCOUNT ADVISORS LLC | 44,867 | 1,470,000 | 0.23% | ||
| 50 | OXFORD ASSET MANAGEMENT LLP | 43,723 | 1,453,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
