| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,794,236 | 190,281,000 | 16.39% | ||
| 2 | JENNISON ASSOCIATES LLC | 2,160,438 | 108,346,000 | 9.34% | ||
| 3 | Palo Alto Investors LP | 1,382,722 | 69,344,000 | 5.97% | ||
| 4 | PFM Health Sciences, LP | 1,242,509 | 62,312,000 | 5.37% | ||
| 5 | BlackRock Fund Advisors | 1,096,458 | 54,987,000 | 4.74% | ||
| 6 | ORBIMED ADVISORS LLC | 947,900 | 47,537,000 | 4.10% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 728,704 | 36,545,000 | 3.15% | ||
| 8 | STATE STREET CORP | 702,581 | 35,232,000 | 3.04% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 655,373 | 32,867,000 | 2.83% | ||
| 10 | Bank of New York Mellon Corp | 619,032 | 31,044,000 | 2.67% | ||
| 11 | VANGUARD GROUP INC | 612,378 | 30,710,000 | 2.65% | ||
| 12 | Capital World Investors | 587,300 | 29,453,000 | 2.54% | ||
| 13 | KORNITZER CAPITAL MANAGEMENT INC /KS | 530,635 | 26,611,000 | 2.29% | ||
| 14 | BRIDGER MANAGEMENT, LLC | 444,999 | 22,317,000 | 1.92% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 429,011 | 21,515,000 | 1.85% | ||
| 16 | HealthCor Management, L.P. | 425,000 | 21,314,000 | 1.84% | ||
| 17 | WADDELL & REED FINANCIAL INC | 361,825 | 18,146,000 | 1.56% | ||
| 18 | BAKER BROS. ADVISORS LP | 354,265 | 17,766,000 | 1.53% | ||
| 19 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 298,599 | 14,975,000 | 1.29% | ||
| 20 | WELLINGTON MANAGEMENT GROUP LLP | 295,445 | 14,817,000 | 1.28% | ||
| 21 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 291,708 | 14,629,156 | 1.26% | ||
| 22 | Pentwater Capital Management LP | 275,000 | 13,791,000 | 1.19% | ||
| 23 | DEUTSCHE BANK AG\ | 260,361 | 13,055,000 | 1.12% | ||
| 24 | Redmile Group, LLC | 225,062 | 11,287,000 | 0.97% | ||
| 25 | Allianz Asset Management GmbH | 213,340 | 10,700,000 | 0.92% | ||
| 26 | NORTHERN TRUST CORP | 200,513 | 10,055,000 | 0.87% | ||
| 27 | Invesco Ltd. | 188,383 | 9,447,000 | 0.81% | ||
| 28 | REGENTATLANTIC CAPITAL LLC | 174,454 | 8,749,000 | 0.75% | ||
| 29 | JPMORGAN CHASE & CO | 164,546 | 8,252,000 | 0.71% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 156,200 | 7,833,000 | 0.67% | Put | |
| 31 | MORGAN STANLEY | 144,926 | 7,268,000 | 0.63% | ||
| 32 | PRICE T ROWE ASSOCIATES INC /MD/ | 140,892 | 7,066,000 | 0.61% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 140,345 | 7,038,000 | 0.61% | ||
| 34 | Aureus Asset Management, LLC | 130,307 | 6,535,000 | 0.56% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 118,144 | 5,924,000 | 0.51% | ||
| 36 | TWO SIGMA INVESTMENTS, LP | 117,066 | 5,871,000 | 0.51% | ||
| 37 | Rock Springs Capital Management LP | 115,000 | 5,767,000 | 0.50% | ||
| 38 | RICE HALL JAMES & ASSOCIATES, LLC | 112,080 | 5,621,000 | 0.48% | ||
| 39 | SCOGGIN MANAGEMENT LP | 92,000 | 4,614,000 | 0.40% | ||
| 40 | EAGLE ASSET MANAGEMENT INC | 91,915 | 4,609,000 | 0.40% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 90,800 | 4,554,000 | 0.39% | Call | |
| 42 | SPHERA FUNDS MANAGEMENT LTD. | 90,000 | 4,514,000 | 0.39% | ||
| 43 | C WorldWide Group Holding A/S | 81,517 | 4,088,000 | 0.35% | ||
| 44 | BNP Paribas Asset Management Holding S.A. | 76,555 | 3,839,000 | 0.33% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 76,093 | 3,816,000 | 0.33% | ||
| 46 | Versant Venture Management, LLC | 70,376 | 3,529,356 | 0.30% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,445 | 3,433,000 | 0.30% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 65,566 | 3,288,000 | 0.28% | ||
| 49 | Forward Management, LLC | 66,575 | 2,950,000 | 0.25% | ||
| 50 | D. E. Shaw & Co., Inc. | 58,470 | 2,933,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
