| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,279,635 | 130,399,000 | 18.48% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,527,773 | 60,744,000 | 8.61% | ||
| 3 | PFM Health Sciences, LP | 1,003,492 | 39,899,000 | 5.65% | ||
| 4 | WADDELL & REED FINANCIAL INC | 945,120 | 37,578,000 | 5.32% | ||
| 5 | Palo Alto Investors LP | 905,259 | 35,993,000 | 5.10% | ||
| 6 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 808,347 | 32,139,876 | 4.55% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 794,200 | 31,577,000 | 4.47% | ||
| 8 | BlackRock Fund Advisors | 705,140 | 28,036,000 | 3.97% | ||
| 9 | STATE STREET CORP | 559,731 | 22,257,000 | 3.15% | ||
| 10 | Capital World Investors | 547,300 | 21,761,000 | 3.08% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 512,038 | 20,359,000 | 2.88% | ||
| 12 | Redmile Group, LLC | 443,326 | 17,627,000 | 2.50% | ||
| 13 | Polar Capital LLP | 431,185 | 17,144,000 | 2.43% | ||
| 14 | VANGUARD GROUP INC | 401,501 | 15,964,000 | 2.26% | ||
| 15 | Pentwater Capital Management LP | 390,000 | 15,506,000 | 2.20% | ||
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 367,319 | 14,605,000 | 2.07% | ||
| 17 | BAKER BROS. ADVISORS LP | 311,255 | 12,375,000 | 1.75% | ||
| 18 | RS INVESTMENT MANAGEMENT CO LLC | 288,700 | 11,479,000 | 1.63% | ||
| 19 | Bank of New York Mellon Corp | 221,651 | 8,813,000 | 1.25% | ||
| 20 | REGENTATLANTIC CAPITAL LLC | 176,454 | 7,016,000 | 0.99% | ||
| 21 | ALTRINSIC GLOBAL ADVISORS LLC | 168,154 | 6,686,000 | 0.95% | ||
| 22 | NORTHERN TRUST CORP | 160,038 | 6,364,000 | 0.90% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 144,783 | 5,757,000 | 0.82% | ||
| 24 | Aureus Asset Management, LLC | 136,305 | 5,419,000 | 0.77% | ||
| 25 | Hutchin Hill Capital, LP | 120,000 | 4,771,000 | 0.68% | ||
| 26 | JPMORGAN CHASE & CO | 119,437 | 4,749,000 | 0.67% | ||
| 27 | Allianz Asset Management GmbH | 117,685 | 4,679,000 | 0.66% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 116,400 | 4,628,000 | 0.66% | ||
| 29 | EAGLE ASSET MANAGEMENT INC | 101,287 | 4,027,000 | 0.57% | ||
| 30 | SENZAR ASSET MANAGEMENT, LLC | 89,500 | 3,558,000 | 0.50% | ||
| 31 | ASCEND CAPITAL, LLC | 85,992 | 3,419,000 | 0.48% | ||
| 32 | LORD, ABBETT & CO. LLC | 84,710 | 3,368,000 | 0.48% | ||
| 33 | LOOMIS SAYLES & CO L P | 81,973 | 3,259,000 | 0.46% | ||
| 34 | GUGGENHEIM CAPITAL LLC | 79,342 | 3,155,000 | 0.45% | ||
| 35 | BNP Paribas Asset Management Holding S.A. | 78,242 | 3,111,000 | 0.44% | ||
| 36 | CADIAN CAPITAL MANAGEMENT, LP | 75,000 | 2,982,000 | 0.42% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 68,545 | 2,725,000 | 0.39% | ||
| 38 | DEUTSCHE BANK AG\ | 65,345 | 2,597,000 | 0.37% | ||
| 39 | Forward Management, LLC | 72,970 | 2,528,000 | 0.36% | ||
| 40 | WELLS FARGO & COMPANY/MN | 59,119 | 2,351,000 | 0.33% | ||
| 41 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 56,570 | 2,249,000 | 0.32% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 54,132 | 2,152,000 | 0.30% | ||
| 43 | DRIEHAUS CAPITAL MANAGEMENT LLC | 53,069 | 2,110,000 | 0.30% | ||
| 44 | BBT Capital Management, LLC | 50,000 | 1,988,000 | 0.28% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,038 | 1,910,000 | 0.27% | ||
| 46 | Partner Investment Management, L.P. | 39,399 | 1,567,000 | 0.22% | ||
| 47 | MACKENZIE FINANCIAL CORP | 36,380 | 1,446,000 | 0.20% | ||
| 48 | GREEN ARROW CAPITAL MANAGEMENT LLC | 35,000 | 1,392,000 | 0.20% | ||
| 49 | AMERIPRISE FINANCIAL INC | 32,796 | 1,304,000 | 0.18% | ||
| 50 | BlackRock Investment Management, LLC | 32,720 | 1,301,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
