| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,398,491 | 130,400,000 | 18.22% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,894,903 | 72,707,000 | 10.16% | ||
| 3 | PFM Health Sciences, LP | 952,715 | 36,556,000 | 5.11% | ||
| 4 | Palo Alto Investors LP | 949,959 | 36,450,000 | 5.09% | ||
| 5 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 882,853 | 33,875,000 | 4.73% | ||
| 6 | BlackRock Fund Advisors | 854,064 | 32,770,000 | 4.58% | ||
| 7 | WADDELL & REED FINANCIAL INC | 745,212 | 28,594,000 | 3.99% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | 26,859,000 | 3.75% | ||
| 9 | STATE STREET CORP | 631,392 | 24,230,000 | 3.39% | ||
| 10 | Pentwater Capital Management LP | 610,690 | 23,432,000 | 3.27% | ||
| 11 | Redmile Group, LLC | 560,356 | 21,501,000 | 3.00% | ||
| 12 | Capital World Investors | 547,300 | 21,000,000 | 2.93% | ||
| 13 | Polar Capital LLP | 519,398 | 19,927,000 | 2.78% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 496,779 | 19,061,000 | 2.66% | ||
| 15 | VANGUARD GROUP INC | 415,152 | 15,930,000 | 2.23% | ||
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 320,278 | 12,289,000 | 1.72% | ||
| 17 | BAKER BROS. ADVISORS LP | 311,255 | 11,943,000 | 1.67% | ||
| 18 | RS INVESTMENT MANAGEMENT CO LLC | 283,181 | 10,866,000 | 1.52% | ||
| 19 | Bank of New York Mellon Corp | 267,541 | 10,265,000 | 1.43% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 198,290 | 7,608,000 | 1.06% | ||
| 21 | REGENTATLANTIC CAPITAL LLC | 176,454 | 6,771,000 | 0.95% | ||
| 22 | ALTRINSIC GLOBAL ADVISORS LLC | 168,154 | 6,452,000 | 0.90% | ||
| 23 | Aureus Asset Management, LLC | 152,662 | 5,858,000 | 0.82% | ||
| 24 | NORTHERN TRUST CORP | 149,705 | 5,744,000 | 0.80% | ||
| 25 | Hutchin Hill Capital, LP | 140,000 | 5,372,000 | 0.75% | ||
| 26 | LORD, ABBETT & CO. LLC | 138,307 | 5,307,000 | 0.74% | ||
| 27 | JPMORGAN CHASE & CO | 130,068 | 4,990,000 | 0.70% | ||
| 28 | SENZAR ASSET MANAGEMENT, LLC | 124,900 | 4,792,000 | 0.67% | ||
| 29 | Allianz Asset Management GmbH | 106,670 | 4,093,000 | 0.57% | ||
| 30 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 93,490 | 3,587,000 | 0.50% | ||
| 31 | ASCEND CAPITAL, LLC | 87,208 | 3,346,000 | 0.47% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 85,864 | 3,294,000 | 0.46% | ||
| 33 | KORNITZER CAPITAL MANAGEMENT INC /KS | 85,055 | 3,264,000 | 0.46% | ||
| 34 | BNP Paribas Asset Management Holding S.A. | 82,044 | 3,148,000 | 0.44% | ||
| 35 | EAGLE ASSET MANAGEMENT INC | 70,460 | 2,703,000 | 0.38% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 65,638 | 2,519,000 | 0.35% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,300 | 2,467,000 | 0.34% | Put | |
| 38 | GUGGENHEIM CAPITAL LLC | 58,857 | 2,258,000 | 0.32% | ||
| 39 | HealthCor Management, L.P. | 53,800 | 2,064,000 | 0.29% | ||
| 40 | BlackRock Investment Management, LLC | 50,175 | 1,925,000 | 0.27% | ||
| 41 | BBT Capital Management, LLC | 50,000 | 1,918,000 | 0.27% | ||
| 42 | Tekla Capital Management LLC | 49,000 | 1,880,000 | 0.26% | ||
| 43 | Amici Capital, LLC | 46,000 | 1,765,000 | 0.25% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,025 | 1,728,000 | 0.24% | ||
| 45 | MANAGED ACCOUNT ADVISORS LLC | 43,504 | 1,669,000 | 0.23% | ||
| 46 | RAYMOND JAMES & ASSOCIATES | 38,654 | 1,483,000 | 0.21% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 38,026 | 1,460,000 | 0.20% | ||
| 48 | AMERIPRISE FINANCIAL INC | 36,413 | 1,397,000 | 0.20% | ||
| 49 | Partner Investment Management, L.P. | 36,173 | 1,388,000 | 0.19% | ||
| 50 | AlpInvest Partners B.V. | 33,271 | 1,277,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
