| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,398,491 | 117,860,000 | 17.62% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,632,169 | 56,604,000 | 8.46% | ||
| 3 | Palo Alto Investors LP | 1,121,884 | 38,907,000 | 5.82% | ||
| 4 | PFM Health Sciences, LP | 1,085,315 | 37,639,000 | 5.63% | ||
| 5 | BlackRock Fund Advisors | 990,320 | 34,344,000 | 5.14% | ||
| 6 | STATE STREET CORP | 728,816 | 25,273,000 | 3.78% | ||
| 7 | ORBIMED ADVISORS LLC | 722,900 | 25,070,000 | 3.75% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 587,226 | 20,365,000 | 3.05% | ||
| 9 | Capital World Investors | 547,300 | 20,360,000 | 3.04% | ||
| 10 | KORNITZER CAPITAL MANAGEMENT INC /KS | 532,445 | 18,465,000 | 2.76% | ||
| 11 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 508,418 | 17,631,936 | 2.64% | ||
| 12 | Pentwater Capital Management LP | 500,000 | 17,340,000 | 2.59% | ||
| 13 | VANGUARD GROUP INC | 484,159 | 16,790,000 | 2.51% | ||
| 14 | WADDELL & REED FINANCIAL INC | 430,125 | 14,917,000 | 2.23% | ||
| 15 | ALLIANCEBERNSTEIN L.P. | 428,694 | 14,867,000 | 2.22% | ||
| 16 | Polar Capital LLP | 405,544 | 14,063,000 | 2.10% | ||
| 17 | RS INVESTMENT MANAGEMENT CO LLC | 359,371 | 12,463,000 | 1.86% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 331,213 | 11,486,000 | 1.72% | ||
| 19 | Bank of New York Mellon Corp | 300,184 | 10,411,000 | 1.56% | ||
| 20 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 289,594 | 10,043,000 | 1.50% | ||
| 21 | BAKER BROS. ADVISORS LP | 286,255 | 9,927,000 | 1.48% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 242,425 | 8,407,000 | 1.26% | ||
| 23 | Allianz Asset Management GmbH | 213,340 | 7,398,000 | 1.11% | ||
| 24 | NORTHERN TRUST CORP | 193,313 | 6,704,000 | 1.00% | ||
| 25 | REGENTATLANTIC CAPITAL LLC | 176,454 | 6,119,425 | 0.92% | ||
| 26 | Hutchin Hill Capital, LP | 148,900 | 5,164,000 | 0.77% | ||
| 27 | JPMORGAN CHASE & CO | 126,434 | 4,385,000 | 0.66% | ||
| 28 | Aureus Asset Management, LLC | 124,087 | 4,303,000 | 0.64% | ||
| 29 | Candriam S.C.A. | 120,000 | 4,162,000 | 0.62% | ||
| 30 | Tekla Capital Management LLC | 111,433 | 3,864,000 | 0.58% | ||
| 31 | Versant Venture Management, LLC | 70,376 | 3,529,356 | 0.53% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 99,329 | 3,444,000 | 0.51% | ||
| 33 | RICE HALL JAMES & ASSOCIATES, LLC | 98,378 | 3,412,000 | 0.51% | ||
| 34 | EAGLE ASSET MANAGEMENT INC | 94,798 | 3,287,000 | 0.49% | ||
| 35 | C WorldWide Group Holding A/S | 94,017 | 3,261,000 | 0.49% | ||
| 36 | HealthCor Management, L.P. | 91,600 | 3,177,000 | 0.48% | ||
| 37 | ASCEND CAPITAL, LLC | 91,435 | 3,170,000 | 0.47% | ||
| 38 | BNP Paribas Asset Management Holding S.A. | 83,072 | 2,881,000 | 0.43% | ||
| 39 | Amici Capital, LLC | 80,500 | 2,792,000 | 0.42% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 61,865 | 2,145,000 | 0.32% | ||
| 41 | Granite Investment Partners, LLC | 52,015 | 1,804,000 | 0.27% | ||
| 42 | BlackRock Investment Management, LLC | 50,125 | 1,738,000 | 0.26% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 50,000 | 1,734,000 | 0.26% | Put | |
| 44 | BBT Capital Management, LLC | 50,000 | 1,734,000 | 0.26% | ||
| 45 | DEUTSCHE BANK AG\ | 49,713 | 1,723,000 | 0.26% | ||
| 46 | AlpInvest Partners B.V. | 48,087 | 1,668,000 | 0.25% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,011 | 1,596,000 | 0.24% | ||
| 48 | Forward Management, LLC | 49,550 | 1,588,000 | 0.24% | ||
| 49 | RAYMOND JAMES & ASSOCIATES | 42,179 | 1,463,000 | 0.22% | ||
| 50 | MANAGED ACCOUNT ADVISORS LLC | 40,270 | 1,397,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
