| # | % | |||||
|---|---|---|---|---|---|---|
| 101 | KORNITZER CAPITAL MANAGEMENT INC /KS | 532,445 | 18,465,000 | 2.76% | ||
| 102 | Capital World Investors | 547,300 | 20,360,000 | 3.04% | ||
| 103 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 587,226 | 20,365,000 | 3.05% | ||
| 104 | ORBIMED ADVISORS LLC | 722,900 | 25,070,000 | 3.75% | ||
| 105 | STATE STREET CORP | 728,816 | 25,273,000 | 3.78% | ||
| 106 | BlackRock Fund Advisors | 990,320 | 34,344,000 | 5.14% | ||
| 107 | PFM Health Sciences, LP | 1,085,315 | 37,639,000 | 5.63% | ||
| 108 | Palo Alto Investors LP | 1,121,884 | 38,907,000 | 5.82% | ||
| 109 | JENNISON ASSOCIATES LLC | 1,632,169 | 56,604,000 | 8.46% | ||
| 110 | FMR LLC | 3,398,491 | 117,860,000 | 17.62% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
