| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 9,353,304 | 39,097,000 | 38.13% | ||
| 2 | Broadfin Capital, LLC | 2,787,121 | 11,650,000 | 11.36% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 2,654,485 | 11,096,000 | 10.82% | ||
| 4 | AWM Investment Company, Inc. | 2,451,700 | 10,248,000 | 9.99% | ||
| 5 | SENZAR ASSET MANAGEMENT, LLC | 1,508,266 | 6,304,000 | 6.15% | ||
| 6 | RTW INVESTMENTS, LP | 1,448,991 | 6,057,000 | 5.91% | ||
| 7 | TAMARACK ADVISERS, LP | 1,063,000 | 4,443,000 | 4.33% | ||
| 8 | FRANKLIN RESOURCES INC | 878,690 | 3,673,000 | 3.58% | ||
| 9 | NEEDHAM INVESTMENT MANAGEMENT LLC | 625,624 | 2,615,000 | 2.55% | ||
| 10 | ROYCE & ASSOCIATES LP | 548,464 | 2,293,000 | 2.24% | ||
| 11 | VANGUARD GROUP INC | 500,965 | 2,094,000 | 2.04% | ||
| 12 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 187,000 | 782,000 | 0.76% | ||
| 13 | Opaleye Management Inc. | 162,000 | 677,000 | 0.66% | ||
| 14 | BlackRock Finance, Inc. | 110,128 | 460,000 | 0.45% | ||
| 15 | ESSEX INVESTMENT MANAGEMENT CO LLC | 87,611 | 366,000 | 0.36% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 69,552 | 290,000 | 0.28% | ||
| 17 | NORTHERN TRUST CORP | 36,978 | 155,000 | 0.15% | ||
| 18 | Bank of New York Mellon Corp | 25,269 | 106,000 | 0.10% | ||
| 19 | CITADEL ADVISORS LLC | 10,759 | 45,000 | 0.04% | ||
| 20 | Parallax Volatility Advisers, L.P. | 6,283 | 26,000 | 0.03% | ||
| 21 | VICTORY CAPITAL MANAGEMENT INC | 4,606 | 19,000 | 0.02% | ||
| 22 | UBS Group AG | 3,803 | 16,000 | 0.02% | ||
| 23 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 3,866 | 16,000 | 0.02% | ||
| 24 | WELLS FARGO & COMPANY/MN | 3,000 | 13,000 | 0.01% | ||
| 25 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 912 | 4,000 | 0.00% | ||
| 26 | ROYAL BANK OF CANADA | 7 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
