| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 2,127,854 | 31,833,000 | 20.13% | ||
| 2 | FEDERATED HERMES, INC. | 1,486,153 | 22,233,000 | 14.06% | ||
| 3 | VANGUARD GROUP INC | 852,587 | 12,754,000 | 8.06% | ||
| 4 | BlackRock Fund Advisors | 820,374 | 12,273,000 | 7.76% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 733,932 | 10,980,000 | 6.94% | ||
| 6 | JPMORGAN CHASE & CO | 616,950 | 9,230,000 | 5.84% | ||
| 7 | PICTET ASSET MANAGEMENT LTD | 561,349 | 8,117,000 | 5.13% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 448,532 | 6,710,000 | 4.24% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 325,339 | 4,867,000 | 3.08% | ||
| 10 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 310,417 | 4,644,000 | 2.94% | ||
| 11 | TFS CAPITAL LLC | 308,624 | 4,617,000 | 2.92% | ||
| 12 | Alyeska Investment Group, L.P. | 160,406 | 2,400,000 | 1.52% | ||
| 13 | Endurant Capital Management LP | 152,159 | 2,276,000 | 1.44% | ||
| 14 | TURNER INVESTMENTS LLC | 125,820 | 1,882,000 | 1.19% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 123,380 | 1,846,000 | 1.17% | ||
| 16 | Spark Investment Management LLC | 119,200 | 1,780,000 | 1.13% | ||
| 17 | FMR LLC | 100,000 | 1,496,000 | 0.95% | ||
| 18 | STATE STREET CORP | 99,001 | 1,479,000 | 0.94% | ||
| 19 | NORTHERN TRUST CORP | 94,227 | 1,410,000 | 0.89% | ||
| 20 | TWO SIGMA INVESTMENTS, LP | 87,057 | 1,302,000 | 0.82% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 84,475 | 1,264,000 | 0.80% | ||
| 22 | MORGAN STANLEY | 81,815 | 1,224,000 | 0.77% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 75,254 | 1,125,000 | 0.71% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 72,916 | 1,091,000 | 0.69% | ||
| 25 | CITADEL ADVISORS LLC | 58,162 | 870,000 | 0.55% | ||
| 26 | CREDIT SUISSE AG/ | 48,916 | 732,000 | 0.46% | ||
| 27 | DEUTSCHE BANK AG\ | 48,394 | 723,000 | 0.46% | ||
| 28 | CITIGROUP INC | 47,271 | 707,000 | 0.45% | ||
| 29 | Nationwide Fund Advisors | 40,105 | 600,000 | 0.38% | ||
| 30 | ProShare Advisors LLC | 37,758 | 565,000 | 0.36% | ||
| 31 | D. E. Shaw & Co., Inc. | 35,902 | 537,000 | 0.34% | ||
| 32 | Bank of New York Mellon Corp | 34,791 | 521,000 | 0.33% | ||
| 33 | BlackRock Investment Management, LLC | 27,277 | 408,000 | 0.26% | ||
| 34 | TWO SIGMA ADVISERS, LP | 25,100 | 375,000 | 0.24% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 21,562 | 323,000 | 0.20% | ||
| 36 | DekaBank Deutsche Girozentrale | 20,900 | 313,000 | 0.20% | ||
| 37 | A.R.T. Advisors, LLC | 20,621 | 308,000 | 0.19% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,173 | 257,000 | 0.16% | ||
| 39 | RUSSELL FRANK CO/ | 14,471 | 216,000 | 0.14% | ||
| 40 | GSA CAPITAL PARTNERS LLP | 14,400 | 215,000 | 0.14% | ||
| 41 | WELLS FARGO & COMPANY/MN | 13,004 | 195,000 | 0.12% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,700 | 190,000 | 0.12% | ||
| 43 | BANK OF MONTREAL /CAN/ | 10,886 | 163,000 | 0.10% | ||
| 44 | Airain ltd | 10,700 | 160,000 | 0.10% | ||
| 45 | US BANCORP \DE\ | 9,395 | 141,000 | 0.09% | ||
| 46 | TEACHERS ADVISORS, LLC | 8,611 | 129,000 | 0.08% | ||
| 47 | Fiera Capital (Europe) Ltd. | 8,451 | 126,000 | 0.08% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 7,300 | 109,000 | 0.07% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 5,809 | 86,903 | 0.05% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,138 | 77,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
