| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,016,240 | 33,571,000 | 20.44% | ||
| 2 | ORBIMED ADVISORS LLC | 1,924,500 | 21,420,000 | 13.04% | ||
| 3 | Visium Asset Management, LP | 1,660,626 | 18,483,000 | 11.25% | ||
| 4 | JPMORGAN CHASE & CO | 1,200,944 | 13,367,000 | 8.14% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,164,575 | 12,962,000 | 7.89% | ||
| 6 | Invesco Ltd. | 1,052,629 | 11,716,000 | 7.13% | ||
| 7 | FRANKLIN RESOURCES INC | 864,005 | 9,616,000 | 5.85% | ||
| 8 | Aisling Capital LLC | 770,000 | 8,600,000 | 5.24% | ||
| 9 | VANGUARD GROUP INC | 497,231 | 5,534,000 | 3.37% | ||
| 10 | RA CAPITAL MANAGEMENT, L.P. | 408,333 | 4,545,000 | 2.77% | ||
| 11 | BlackRock Fund Advisors | 336,835 | 3,749,000 | 2.28% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 269,131 | 2,995,000 | 1.82% | ||
| 13 | Tekla Capital Management LLC | 243,920 | 2,715,000 | 1.65% | ||
| 14 | GREAT POINT PARTNERS LLC | 157,661 | 1,755,000 | 1.07% | ||
| 15 | STATE STREET CORP | 138,480 | 1,539,000 | 0.94% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 136,100 | 1,515,000 | 0.92% | ||
| 17 | NORTHERN TRUST CORP | 134,146 | 1,494,000 | 0.91% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 112,108 | 1,248,000 | 0.76% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 95,662 | 1,064,000 | 0.65% | ||
| 20 | Bank of New York Mellon Corp | 66,113 | 736,000 | 0.45% | ||
| 21 | Weiss Multi-Strategy Advisers LLC | 65,000 | 723,000 | 0.44% | ||
| 22 | COLUMBUS CIRCLE INVESTORS | 58,373 | 650,000 | 0.40% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,795 | 476,000 | 0.29% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,520 | 395,000 | 0.24% | ||
| 25 | BlackRock Investment Management, LLC | 33,418 | 372,000 | 0.23% | ||
| 26 | GOLDMAN SACHS GROUP INC | 30,449 | 339,000 | 0.21% | ||
| 27 | Carnick & Kubik, LLC | 30,355 | 338,000 | 0.21% | ||
| 28 | CREDIT SUISSE AG/ | 29,951 | 334,000 | 0.20% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,841 | 243,000 | 0.15% | ||
| 30 | DEUTSCHE BANK AG\ | 20,445 | 226,000 | 0.14% | ||
| 31 | TEACHERS ADVISORS, LLC | 16,892 | 188,000 | 0.11% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,700 | 153,000 | 0.09% | ||
| 33 | Gilman Hill Asset Management, LLC | 13,253 | 148,000 | 0.09% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,200 | 147,000 | 0.09% | Call | |
| 35 | ProShare Advisors LLC | 12,213 | 136,000 | 0.08% | ||
| 36 | MORGAN STANLEY | 10,881 | 121,000 | 0.07% | ||
| 37 | CITIGROUP INC | 9,286 | 104,000 | 0.06% | ||
| 38 | Nationwide Fund Advisors | 9,124 | 102,000 | 0.06% | ||
| 39 | AMERICAN INTERNATIONAL GROUP, INC. | 8,203 | 91,299 | 0.06% | ||
| 40 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,793 | 76,000 | 0.05% | ||
| 41 | BLACKROCK ADVISORS LLC | 6,463 | 72,000 | 0.04% | ||
| 42 | BANK OF MONTREAL /CAN/ | 6,326 | 71,000 | 0.04% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 3,643 | 41,000 | 0.02% | ||
| 44 | GROUP ONE TRADING LLC | 2,176 | 24,000 | 0.01% | ||
| 45 | UBS AG | 1,800 | 20,000 | 0.01% | Call | |
| 46 | UBS AG | 1,479 | 17,000 | 0.01% | ||
| 47 | Tower Research Capital LLC (TRC) | 1,374 | 16,000 | 0.01% | ||
| 48 | Stevens First Principles Investment Advisors | 1,000 | 11,000 | 0.01% | ||
| 49 | UBS AG | 500 | 6,000 | 0.00% | Put | |
| 50 | BARCLAYS PLC | 470 | 5,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
