| 1 |
FMR LLC |
2,967,642 |
20,477,000 |
23.14% |
|
|
| 2 |
ORBIMED ADVISORS LLC |
1,924,500 |
13,279,000 |
15.01% |
|
|
| 3 |
Visium Asset Management, LP |
1,660,626 |
11,458,000 |
12.95% |
|
|
| 4 |
JPMORGAN CHASE & CO |
1,348,095 |
9,302,000 |
10.51% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
1,096,267 |
7,564,000 |
8.55% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,011,793 |
6,981,000 |
7.89% |
|
|
| 7 |
Aisling Capital LLC |
761,800 |
5,260,000 |
5.94% |
|
|
| 8 |
VANGUARD GROUP INC |
499,865 |
3,449,000 |
3.90% |
|
|
| 9 |
SABBY MANAGEMENT, LLC |
263,723 |
1,820,000 |
2.06% |
|
|
| 10 |
Tekla Capital Management LLC |
243,920 |
1,683,000 |
1.90% |
|
|
| 11 |
EVENTIDE ASSET MANAGEMENT, LLC |
201,600 |
1,391,000 |
1.57% |
|
|
| 12 |
COLUMBUS CIRCLE INVESTORS |
164,212 |
1,133,000 |
1.28% |
|
|
| 13 |
GREAT POINT PARTNERS LLC |
157,661 |
1,088,000 |
1.23% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
87,404 |
603,000 |
0.68% |
|
|
| 15 |
Weiss Multi-Strategy Advisers LLC |
65,000 |
449,000 |
0.51% |
|
|
| 16 |
GOLDMAN SACHS GROUP INC |
62,045 |
428,000 |
0.48% |
|
|
| 17 |
DEUTSCHE BANK AG\ |
60,370 |
416,000 |
0.47% |
|
|
| 18 |
PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC |
40,983 |
283,000 |
0.32% |
|
|
| 19 |
BlackRock Fund Advisors |
39,447 |
272,000 |
0.31% |
|
|
| 20 |
Carnick & Kubik, LLC |
30,355 |
209,000 |
0.24% |
|
|
| 21 |
NORTHERN TRUST CORP |
27,041 |
187,000 |
0.21% |
|
|
| 22 |
Bank of New York Mellon Corp |
22,487 |
155,000 |
0.18% |
|
|
| 23 |
MILLENNIUM MANAGEMENT LLC |
18,530 |
128,000 |
0.14% |
|
|
| 24 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
18,000 |
124,000 |
0.14% |
Put |
|
| 25 |
Gilman Hill Asset Management, LLC |
12,899 |
89,000 |
0.10% |
|
|
| 26 |
J.P. Morgan Private Wealth Advisors LLC |
12,142 |
84,000 |
0.09% |
|
|
| 27 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,600 |
73,000 |
0.08% |
Call |
|
| 28 |
BANK OF AMERICA CORP /DE/ |
3,453 |
24,000 |
0.03% |
|
|
| 29 |
Tower Research Capital LLC (TRC) |
3,326 |
23,000 |
0.03% |
|
|
| 30 |
BlackRock Investment Management, LLC |
3,032 |
21,000 |
0.02% |
|
|
| 31 |
MORGAN STANLEY |
1,600 |
11,000 |
0.01% |
|
|
| 32 |
Stevens First Principles Investment Advisors |
1,500 |
10,000 |
0.01% |
|
|
| 33 |
UBS AG |
836 |
5,000 |
0.01% |
|
|
| 34 |
GROUP ONE TRADING LLC |
376 |
3,000 |
0.00% |
|
|
| 35 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
118 |
1,000 |
0.00% |
|
|
| 36 |
BARCLAYS PLC |
154 |
1,000 |
0.00% |
|
|
| 37 |
Creative Planning |
142 |
1,000 |
0.00% |
|
|
| 38 |
Ground Swell Capital, LLC |
200 |
1,000 |
0.00% |
|
|
| 39 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
