| 1 |
FMR LLC |
4,238,297 |
18,097,000 |
17.80% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
2,939,876 |
12,553,000 |
12.35% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
2,592,067 |
11,068,000 |
10.89% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
2,424,500 |
10,353,000 |
10.18% |
|
|
| 5 |
Point72 Asset Management, L.P. |
1,650,000 |
7,046,000 |
6.93% |
|
|
| 6 |
New Leaf Venture Partners, L.L.C. |
1,601,390 |
6,838,000 |
6.73% |
|
|
| 7 |
Visium Asset Management, LP |
1,021,099 |
4,361,000 |
4.29% |
|
|
| 8 |
Aisling Capital LLC |
1,011,800 |
4,320,000 |
4.25% |
|
|
| 9 |
JPMORGAN CHASE & CO |
756,827 |
3,231,000 |
3.18% |
|
|
| 10 |
VANGUARD GROUP INC |
687,833 |
2,937,000 |
2.89% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
674,407 |
2,880,000 |
2.83% |
|
|
| 12 |
EverPoint Asset Management, LLC |
650,000 |
2,776,000 |
2.73% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
600,000 |
2,562,000 |
2.52% |
|
|
| 14 |
Candriam S.C.A. |
447,300 |
1,910,000 |
1.88% |
|
|
| 15 |
Forward Management, LLC |
434,027 |
1,871,000 |
1.84% |
|
|
| 16 |
COLUMBUS CIRCLE INVESTORS |
354,089 |
1,512,000 |
1.49% |
|
|
| 17 |
Iguana Healthcare Management, LLC |
250,000 |
1,068,000 |
1.05% |
|
|
| 18 |
Tekla Capital Management LLC |
243,920 |
1,042,000 |
1.02% |
|
|
| 19 |
GREAT POINT PARTNERS LLC |
157,661 |
673,000 |
0.66% |
|
|
| 20 |
Anson Funds Management LP |
125,000 |
534,000 |
0.53% |
|
|
| 21 |
Endurant Capital Management LP |
110,038 |
470,000 |
0.46% |
|
|
| 22 |
Iguana Healthcare Management, LLC |
100,000 |
427,000 |
0.42% |
Call |
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
87,584 |
373,000 |
0.37% |
|
|
| 24 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
67,100 |
287,000 |
0.28% |
|
|
| 25 |
Weiss Multi-Strategy Advisers LLC |
65,000 |
278,000 |
0.27% |
|
|
| 26 |
BlackRock Fund Advisors |
59,944 |
256,000 |
0.25% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
60,370 |
256,000 |
0.25% |
|
|
| 28 |
TUDOR INVESTMENT CORP ET AL |
50,000 |
214,000 |
0.21% |
|
|
| 29 |
GOLDMAN SACHS GROUP INC |
47,515 |
203,000 |
0.20% |
|
|
| 30 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
35,910 |
153,000 |
0.15% |
|
|
| 31 |
TWO SIGMA INVESTMENTS, LP |
33,760 |
144,000 |
0.14% |
|
|
| 32 |
Carnick & Kubik, LLC |
30,355 |
130,000 |
0.13% |
|
|
| 33 |
NORTHERN TRUST CORP |
27,041 |
115,000 |
0.11% |
|
|
| 34 |
EVENTIDE ASSET MANAGEMENT, LLC |
25,582 |
109,000 |
0.11% |
|
|
| 35 |
CREDIT SUISSE AG/ |
22,614 |
97,000 |
0.10% |
|
|
| 36 |
Bank of New York Mellon Corp |
22,487 |
96,000 |
0.09% |
|
|
| 37 |
TFS CAPITAL LLC |
15,652 |
67,000 |
0.07% |
|
|
| 38 |
Gilman Hill Asset Management, LLC |
15,399 |
66,000 |
0.06% |
|
|
| 39 |
STIFEL FINANCIAL CORP |
15,300 |
65,000 |
0.06% |
|
|
| 40 |
Connor, Clark & Lunn Investment Management Ltd. |
12,800 |
55,000 |
0.05% |
|
|
| 41 |
J.P. Morgan Private Wealth Advisors LLC |
12,142 |
52,000 |
0.05% |
|
|
| 42 |
CITADEL ADVISORS LLC |
10,779 |
46,000 |
0.05% |
|
|
| 43 |
BANK OF AMERICA CORP /DE/ |
5,553 |
24,000 |
0.02% |
|
|
| 44 |
BlackRock Investment Management, LLC |
4,332 |
18,000 |
0.02% |
|
|
| 45 |
GROUP ONE TRADING LLC |
3,793 |
16,000 |
0.02% |
|
|
| 46 |
MORGAN STANLEY |
2,600 |
12,000 |
0.01% |
|
|
| 47 |
Stevens First Principles Investment Advisors |
1,500 |
6,000 |
0.01% |
|
|
| 48 |
UBS Group AG |
634 |
3,000 |
0.00% |
|
|
| 49 |
Creative Planning |
142 |
1,000 |
0.00% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
198 |
1,000 |
0.00% |
|
|
