| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,748,896 | 17,428,000 | 20.68% | ||
| 2 | ORBIMED ADVISORS LLC | 1,924,500 | 12,201,000 | 14.48% | ||
| 3 | Visium Asset Management, LP | 1,660,626 | 10,528,000 | 12.49% | ||
| 4 | JPMORGAN CHASE & CO | 1,446,243 | 9,169,000 | 10.88% | ||
| 5 | FRANKLIN RESOURCES INC | 1,330,067 | 8,433,000 | 10.01% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,132,376 | 7,179,000 | 8.52% | ||
| 7 | Aisling Capital LLC | 770,000 | 4,880,000 | 5.79% | ||
| 8 | VANGUARD GROUP INC | 477,301 | 3,026,000 | 3.59% | ||
| 9 | SABBY MANAGEMENT, LLC | 270,000 | 1,712,000 | 2.03% | ||
| 10 | Tekla Capital Management LLC | 243,920 | 1,546,000 | 1.83% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 201,600 | 1,278,000 | 1.52% | ||
| 12 | GREAT POINT PARTNERS LLC | 157,661 | 1,000,000 | 1.19% | ||
| 13 | COLUMBUS CIRCLE INVESTORS | 128,533 | 815,000 | 0.97% | ||
| 14 | NORTHERN TRUST CORP | 107,761 | 683,000 | 0.81% | ||
| 15 | BANK OF AMERICA CORP /DE/ | 95,662 | 606,000 | 0.72% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 87,460 | 554,000 | 0.66% | ||
| 17 | Paloma Partners Management Co | 85,314 | 541,000 | 0.64% | ||
| 18 | Weiss Multi-Strategy Advisers LLC | 65,000 | 412,000 | 0.49% | ||
| 19 | CREDIT SUISSE AG/ | 54,984 | 349,000 | 0.41% | ||
| 20 | DEUTSCHE BANK AG\ | 43,478 | 275,000 | 0.33% | ||
| 21 | BlackRock Fund Advisors | 37,507 | 238,000 | 0.28% | ||
| 22 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 34,527 | 219,000 | 0.26% | ||
| 23 | Carnick & Kubik, LLC | 30,355 | 192,000 | 0.23% | ||
| 24 | LMR Partners LLP | 26,111 | 166,000 | 0.20% | ||
| 25 | Bank of New York Mellon Corp | 22,487 | 143,000 | 0.17% | ||
| 26 | GOLDMAN SACHS GROUP INC | 22,119 | 140,000 | 0.17% | ||
| 27 | SOROS FUND MANAGEMENT LLC | 15,900 | 101,000 | 0.12% | ||
| 28 | Virtu KCG Holdings LLC | 13,538 | 86,000 | 0.10% | ||
| 29 | CITIGROUP INC | 13,313 | 84,000 | 0.10% | ||
| 30 | Gilman Hill Asset Management, LLC | 12,896 | 82,000 | 0.10% | ||
| 31 | MORGAN STANLEY | 12,420 | 79,000 | 0.09% | ||
| 32 | J.P. Morgan Private Wealth Advisors LLC | 12,142 | 77,000 | 0.09% | ||
| 33 | BlackRock Investment Management, LLC | 2,921 | 19,000 | 0.02% | ||
| 34 | Stevens First Principles Investment Advisors | 1,500 | 10,000 | 0.01% | ||
| 35 | GROUP ONE TRADING LLC | 976 | 6,000 | 0.01% | ||
| 36 | UBS AG | 791 | 5,000 | 0.01% | ||
| 37 | Tower Research Capital LLC (TRC) | 401 | 3,000 | 0.00% | ||
| 38 | BANK OF MONTREAL /CAN/ | 300 | 2,000 | 0.00% | ||
| 39 | BNP PARIBAS FINANCIAL MARKETS | 284 | 1,801 | 0.00% | ||
| 40 | Creative Planning | 142 | 1,000 | 0.00% | ||
| 41 | UBS AG | 100 | 1,000 | 0.00% | Put | |
| 42 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 118 | 1,000 | 0.00% | ||
| 43 | Ground Swell Capital, LLC | 200 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
