| 1 |
FMR LLC |
1,450,921 |
2,597,000 |
17.22% |
|
|
| 2 |
FIRST MANHATTAN CO. LLC. |
1,050,000 |
1,879,000 |
12.46% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
802,568 |
1,437,000 |
9.53% |
|
|
| 4 |
VANGUARD GROUP INC |
790,921 |
1,415,000 |
9.38% |
|
|
| 5 |
PANAGORA ASSET MANAGEMENT INC |
649,580 |
1,163,000 |
7.71% |
|
|
| 6 |
BVF INC/IL |
600,000 |
1,074,000 |
7.12% |
|
|
| 7 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
451,368 |
808,000 |
5.36% |
|
|
| 8 |
SABBY MANAGEMENT, LLC |
296,491 |
531,000 |
3.52% |
|
|
| 9 |
GROUP ONE TRADING LLC |
231,871 |
415,000 |
2.75% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
222,643 |
399,000 |
2.65% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
175,189 |
314,000 |
2.08% |
|
|
| 12 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
169,100 |
303,000 |
2.01% |
Call |
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
150,000 |
269,000 |
1.78% |
Put |
|
| 14 |
Iguana Healthcare Management, LLC |
150,000 |
269,000 |
1.78% |
|
|
| 15 |
MORGAN STANLEY |
135,915 |
243,000 |
1.61% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
127,753 |
228,000 |
1.51% |
|
|
| 17 |
Endurant Capital Management LP |
95,438 |
171,000 |
1.13% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
84,100 |
151,000 |
1.00% |
Put |
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
72,820 |
130,000 |
0.86% |
|
|
| 20 |
TFS CAPITAL LLC |
70,155 |
126,000 |
0.84% |
|
|
| 21 |
SIMPLEX TRADING, LLC |
70,249 |
125,000 |
0.83% |
|
|
| 22 |
CREDIT SUISSE AG/ |
68,754 |
123,000 |
0.82% |
|
|
| 23 |
BlackRock Fund Advisors |
67,987 |
122,000 |
0.81% |
|
|
| 24 |
GREAT POINT PARTNERS LLC |
52,254 |
94,000 |
0.62% |
|
|
| 25 |
Connor, Clark & Lunn Investment Management Ltd. |
43,300 |
78,000 |
0.52% |
|
|
| 26 |
JPMORGAN CHASE & CO |
43,356 |
77,000 |
0.51% |
|
|
| 27 |
NORTHERN TRUST CORP |
42,841 |
77,000 |
0.51% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
30,500 |
55,000 |
0.36% |
Call |
|
| 29 |
Carnick & Kubik, LLC |
30,355 |
54,000 |
0.36% |
|
|
| 30 |
Opus Point Partners Management, LLC |
30,000 |
54,000 |
0.36% |
|
|
| 31 |
Bank of New York Mellon Corp |
22,487 |
40,000 |
0.27% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
21,543 |
39,000 |
0.26% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
20,370 |
36,000 |
0.24% |
|
|
| 34 |
Visium Asset Management, LP |
16,411 |
29,000 |
0.19% |
|
|
| 35 |
Gilman Hill Asset Management, LLC |
15,399 |
28,000 |
0.19% |
|
|
| 36 |
DENVER INVESTMENT ADVISORS LLC |
15,739 |
28,000 |
0.19% |
|
|
| 37 |
PNC FINANCIAL SERVICES GROUP, INC. |
13,000 |
23,000 |
0.15% |
|
|
| 38 |
STIFEL FINANCIAL CORP |
12,700 |
23,000 |
0.15% |
|
|
| 39 |
GOLDMAN SACHS GROUP INC |
10,100 |
18,000 |
0.12% |
Put |
|
| 40 |
CITIGROUP INC |
6,447 |
12,000 |
0.08% |
|
|
| 41 |
BlackRock Investment Management, LLC |
4,499 |
8,000 |
0.05% |
|
|
| 42 |
BlackRock Japan Co. Ltd |
2,580 |
5,000 |
0.03% |
|
|
| 43 |
WELLS FARGO & COMPANY/MN |
2,000 |
4,000 |
0.03% |
|
|
| 44 |
Creative Planning |
1,142 |
2,000 |
0.01% |
|
|
| 45 |
UBS Group AG |
1,207 |
2,000 |
0.01% |
|
|
| 46 |
CITIGROUP INC |
1,000 |
2,000 |
0.01% |
Call |
|
| 47 |
SOUTH GEORGIA CAPITAL, LLC |
1,000 |
2,000 |
0.01% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
300 |
1,000 |
0.01% |
|
|
| 49 |
Aisling Capital LLC |
0 |
0 |
0.00% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
198 |
0 |
0.00% |
|
|
