| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,337,292 | 114,102,000 | 27.15% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,047,679 | 70,010,000 | 16.66% | ||
| 3 | VHCP Management, LLC | 1,382,735 | 42,833,000 | 10.19% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,032,750 | 34,220,000 | 8.14% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 731,208 | 25,000,000 | 5.95% | ||
| 6 | Redmile Group, LLC | 699,460 | 21,531,000 | 5.12% | ||
| 7 | JPMORGAN CHASE & CO | 447,748 | 15,309,000 | 3.64% | ||
| 8 | FRONTIER CAPITAL MANAGEMENT CO LLC | 395,947 | 13,537,000 | 3.22% | ||
| 9 | Tourbillon Capital Partners, L.P. | 300,000 | 10,257,000 | 2.44% | ||
| 10 | COWEN INC. | 248,674 | 8,502,000 | 2.02% | ||
| 11 | GOLDMAN SACHS GROUP INC | 195,283 | 6,677,000 | 1.59% | ||
| 12 | BlackRock Fund Advisors | 169,950 | 5,811,000 | 1.38% | ||
| 13 | VANGUARD GROUP INC | 151,782 | 5,190,000 | 1.23% | ||
| 14 | QVT Financial LP | 120,000 | 4,103,000 | 0.98% | ||
| 15 | FRANKLIN RESOURCES INC | 116,300 | 3,976,000 | 0.95% | ||
| 16 | LORD, ABBETT & CO. LLC | 102,079 | 3,490,000 | 0.83% | ||
| 17 | JENNISON ASSOCIATES LLC | 100,000 | 3,419,000 | 0.81% | ||
| 18 | Cormorant Asset Management, LP | 65,000 | 2,222,000 | 0.53% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 57,307 | 1,959,000 | 0.47% | ||
| 20 | STATE STREET CORP | 56,800 | 1,940,000 | 0.46% | ||
| 21 | BLACKROCK ADVISORS LLC | 53,553 | 1,831,000 | 0.44% | ||
| 22 | Pine River Capital Management L.P. | 51,790 | 1,771,000 | 0.42% | ||
| 23 | Ghost Tree Capital, LLC | 50,000 | 1,710,000 | 0.41% | ||
| 24 | SABBY MANAGEMENT, LLC | 50,000 | 1,710,000 | 0.41% | ||
| 25 | CITADEL ADVISORS LLC | 46,317 | 1,584,000 | 0.38% | ||
| 26 | PRIMECAP MANAGEMENT CO/CA/ | 45,900 | 1,569,000 | 0.37% | ||
| 27 | MARSHALL WACE, LLP | 45,412 | 1,553,000 | 0.37% | ||
| 28 | DRIEHAUS CAPITAL MANAGEMENT LLC | 34,175 | 1,168,000 | 0.28% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 33,970 | 1,161,000 | 0.28% | ||
| 30 | CQS Cayman LP | 33,000 | 1,128,000 | 0.27% | ||
| 31 | FEDERATED HERMES, INC. | 30,000 | 1,026,000 | 0.24% | ||
| 32 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 28,800 | 985,000 | 0.23% | ||
| 33 | Lombard Odier Asset Management (USA) Corp | 24,987 | 854,000 | 0.20% | ||
| 34 | PANAGORA ASSET MANAGEMENT INC | 24,511 | 838,000 | 0.20% | ||
| 35 | BlackRock Investment Management, LLC | 22,973 | 785,000 | 0.19% | ||
| 36 | Bank of New York Mellon Corp | 22,448 | 767,000 | 0.18% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 20,666 | 707,000 | 0.17% | ||
| 38 | EVENTIDE ASSET MANAGEMENT, LLC | 20,000 | 684,000 | 0.16% | ||
| 39 | Spark Investment Management LLC | 14,500 | 495,000 | 0.12% | ||
| 40 | NORTHERN TRUST CORP | 14,479 | 495,000 | 0.12% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,700 | 434,000 | 0.10% | ||
| 42 | DEUTSCHE BANK AG\ | 9,539 | 326,000 | 0.08% | ||
| 43 | MORGAN STANLEY | 8,923 | 305,000 | 0.07% | ||
| 44 | METROPOLITAN LIFE INSURANCE CO/NY | 8,660 | 296,000 | 0.07% | ||
| 45 | SEI TRUST CO | 8,034 | 275,000 | 0.07% | ||
| 46 | BANK OF MONTREAL /CAN/ | 7,761 | 265,000 | 0.06% | ||
| 47 | TD ASSET MANAGEMENT INC | 7,500 | 256,000 | 0.06% | ||
| 48 | Nationwide Fund Advisors | 7,369 | 252,000 | 0.06% | ||
| 49 | Rock Springs Capital Management LP | 7,198 | 246,000 | 0.06% | ||
| 50 | TEACHERS ADVISORS, LLC | 6,431 | 220,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
