| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,852,871 | 19,919,000 | 24.82% | ||
| 2 | GREAT POINT PARTNERS LLC | 1,295,416 | 6,697,000 | 8.34% | ||
| 3 | VHCP Management, LLC | 1,102,735 | 5,701,000 | 7.10% | ||
| 4 | Numeric Investors LLC | 984,309 | 5,089,000 | 6.34% | ||
| 5 | BlackRock Fund Advisors | 835,270 | 4,318,000 | 5.38% | ||
| 6 | VANGUARD GROUP INC | 675,546 | 3,492,000 | 4.35% | ||
| 7 | SABBY MANAGEMENT, LLC | 540,632 | 2,795,000 | 3.48% | ||
| 8 | PRIMECAP MANAGEMENT CO/CA/ | 427,000 | 2,208,000 | 2.75% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 419,751 | 2,170,000 | 2.70% | ||
| 10 | Connor, Clark & Lunn Investment Management Ltd. | 312,250 | 1,614,000 | 2.01% | ||
| 11 | STATE STREET CORP | 279,599 | 1,448,000 | 1.80% | ||
| 12 | VHCP MANAGEMENT II, LLC | 280,000 | 1,448,000 | 1.80% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 278,700 | 1,441,000 | 1.80% | ||
| 14 | Gruss Capital Management LP | 260,000 | 1,344,000 | 1.67% | ||
| 15 | Wildcat Capital Management, LLC | 235,264 | 1,216,000 | 1.51% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 228,947 | 1,184,000 | 1.48% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 224,500 | 1,161,000 | 1.45% | ||
| 18 | NORTHERN TRUST CORP | 214,840 | 1,110,000 | 1.38% | ||
| 19 | GOLDMAN SACHS GROUP INC | 212,191 | 1,097,000 | 1.37% | ||
| 20 | GOLDMAN SACHS GROUP INC | 200,000 | 1,034,000 | 1.29% | Put | |
| 21 | ROYCE & ASSOCIATES LP | 193,346 | 1,000,000 | 1.25% | ||
| 22 | JW Asset Management, LLC | 189,919 | 982,000 | 1.22% | ||
| 23 | NORGES BANK | 167,273 | 865,000 | 1.08% | ||
| 24 | Rhenman & Partners Asset Management AB | 154,006 | 796,000 | 0.99% | ||
| 25 | DAFNA Capital Management LLC | 140,600 | 727,000 | 0.91% | ||
| 26 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 123,363 | 637,000 | 0.79% | ||
| 27 | CADIAN CAPITAL MANAGEMENT, LP | 113,873 | 589,000 | 0.73% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,860 | 568,000 | 0.71% | ||
| 29 | AQR CAPITAL MANAGEMENT LLC | 104,726 | 541,000 | 0.67% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 99,191 | 513,000 | 0.64% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 95,182 | 492,000 | 0.61% | ||
| 32 | A.R.T. Advisors, LLC | 93,597 | 483,000 | 0.60% | ||
| 33 | JPMORGAN CHASE & CO | 81,467 | 421,000 | 0.52% | ||
| 34 | BlackRock Investment Management, LLC | 69,154 | 358,000 | 0.45% | ||
| 35 | DEUTSCHE BANK AG\ | 67,302 | 347,000 | 0.43% | ||
| 36 | KNOTT DAVID M | 66,000 | 341,220 | 0.43% | ||
| 37 | Bank of New York Mellon Corp | 58,659 | 303,000 | 0.38% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 52,000 | 269,000 | 0.34% | ||
| 39 | GILDER GAGNON HOWE & CO LLC | 50,981 | 264,000 | 0.33% | ||
| 40 | Jefferies Group LLC | 50,000 | 259,000 | 0.32% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,387 | 214,000 | 0.27% | ||
| 42 | TEACHERS ADVISORS, LLC | 36,769 | 190,000 | 0.24% | ||
| 43 | TFS CAPITAL LLC | 34,418 | 178,000 | 0.22% | ||
| 44 | Trexquant Investment LP | 32,225 | 167,000 | 0.21% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,600 | 158,000 | 0.20% | Call | |
| 46 | TWO SIGMA ADVISERS, LP | 29,500 | 153,000 | 0.19% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,209 | 146,000 | 0.18% | ||
| 48 | JACOBS LEVY EQUITY MANAGEMENT, INC | 27,400 | 142,000 | 0.18% | ||
| 49 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 22,928 | 119,000 | 0.15% | ||
| 50 | ELLINGTON MANAGEMENT GROUP LLC | 22,400 | 116,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
