| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,846,483 | 31,695,000 | 21.20% | ||
| 2 | CADIAN CAPITAL MANAGEMENT, LP | 1,481,686 | 12,209,000 | 8.17% | ||
| 3 | VHCP Management, LLC | 1,382,735 | 11,394,000 | 7.62% | ||
| 4 | BlackRock Fund Advisors | 886,901 | 7,308,000 | 4.89% | ||
| 5 | Redmile Group, LLC | 748,420 | 6,167,000 | 4.12% | ||
| 6 | Numeric Investors LLC | 743,534 | 6,127,000 | 4.10% | ||
| 7 | AXA S.A. | 706,846 | 5,824,000 | 3.90% | ||
| 8 | SABBY MANAGEMENT, LLC | 574,260 | 4,732,000 | 3.16% | ||
| 9 | VANGUARD GROUP INC | 562,791 | 4,638,000 | 3.10% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 451,652 | 3,722,000 | 2.49% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 426,993 | 3,518,000 | 2.35% | ||
| 12 | PRIMECAP MANAGEMENT CO/CA/ | 372,400 | 3,069,000 | 2.05% | ||
| 13 | ASCEND CAPITAL, LLC | 359,400 | 2,960,000 | 1.98% | ||
| 14 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 301,249 | 2,482,000 | 1.66% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 289,800 | 2,388,000 | 1.60% | Put | |
| 16 | FRONTIER CAPITAL MANAGEMENT CO LLC | 280,665 | 2,313,000 | 1.55% | ||
| 17 | Gruss Capital Management LP | 260,000 | 2,142,000 | 1.43% | ||
| 18 | Wildcat Capital Management, LLC | 250,264 | 2,063,000 | 1.38% | ||
| 19 | Green Owl Capital Management, LLC | 250,000 | 2,060,000 | 1.38% | ||
| 20 | STATE STREET CORP | 233,153 | 1,923,000 | 1.29% | ||
| 21 | NORTHERN TRUST CORP | 209,509 | 1,726,000 | 1.15% | ||
| 22 | Connor, Clark & Lunn Investment Management Ltd. | 199,600 | 1,645,000 | 1.10% | ||
| 23 | ROYCE & ASSOCIATES LP | 182,000 | 1,500,000 | 1.00% | ||
| 24 | A.R.T. Advisors, LLC | 171,198 | 1,410,000 | 0.94% | ||
| 25 | NORGES BANK | 167,273 | 1,378,000 | 0.92% | ||
| 26 | Rhenman & Partners Asset Management AB | 154,006 | 1,269,000 | 0.85% | ||
| 27 | GOLDMAN SACHS GROUP INC | 152,101 | 1,253,000 | 0.84% | ||
| 28 | DAFNA Capital Management LLC | 140,600 | 1,159,000 | 0.78% | ||
| 29 | PEAK6 Group LLC | 138,700 | 1,143,000 | 0.76% | Put | |
| 30 | CQS Cayman LP | 138,406 | 1,140,000 | 0.76% | ||
| 31 | GROUP ONE TRADING LLC | 135,170 | 1,114,000 | 0.75% | ||
| 32 | TURNER INVESTMENTS LLC | 111,090 | 915,000 | 0.61% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,860 | 905,000 | 0.61% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 100,600 | 829,000 | 0.55% | Call | |
| 35 | Bank of New York Mellon Corp | 87,815 | 723,000 | 0.48% | ||
| 36 | PEAK6 Group LLC | 87,066 | 717,000 | 0.48% | ||
| 37 | JPMORGAN CHASE & CO | 86,244 | 711,000 | 0.48% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 80,000 | 659,000 | 0.44% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,278 | 645,000 | 0.43% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 73,506 | 604,000 | 0.40% | ||
| 41 | BlackRock Investment Management, LLC | 67,766 | 558,000 | 0.37% | ||
| 42 | PEAK6 Group LLC | 67,500 | 556,000 | 0.37% | Call | |
| 43 | PANAGORA ASSET MANAGEMENT INC | 64,314 | 530,000 | 0.35% | ||
| 44 | FRED ALGER MANAGEMENT, LLC | 63,950 | 527,000 | 0.35% | ||
| 45 | Laurion Capital Management LP | 60,300 | 497,000 | 0.33% | ||
| 46 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 58,100 | 479,000 | 0.32% | ||
| 47 | Jefferies Group LLC | 50,000 | 412,000 | 0.28% | ||
| 48 | GOLDMAN SACHS GROUP INC | 36,000 | 297,000 | 0.20% | Put | |
| 49 | TFS CAPITAL LLC | 35,634 | 294,000 | 0.20% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,602 | 293,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
