| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,824,438 | 62,109,000 | 21.97% | ||
| 2 | VHCP Management, LLC | 1,382,735 | 22,455,000 | 7.94% | ||
| 3 | CADIAN CAPITAL MANAGEMENT, LP | 1,008,337 | 16,375,000 | 5.79% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 984,884 | 15,995,000 | 5.66% | ||
| 5 | BlackRock Fund Advisors | 839,620 | 13,635,000 | 4.82% | ||
| 6 | FRONTIER CAPITAL MANAGEMENT CO LLC | 800,499 | 13,000,000 | 4.60% | ||
| 7 | JPMORGAN CHASE & CO | 643,319 | 10,448,000 | 3.70% | ||
| 8 | Redmile Group, LLC | 537,282 | 8,725,000 | 3.09% | ||
| 9 | VANGUARD GROUP INC | 527,665 | 8,570,000 | 3.03% | ||
| 10 | Invesco Ltd. | 390,955 | 6,348,000 | 2.25% | ||
| 11 | Laurion Capital Management LP | 375,542 | 6,099,000 | 2.16% | ||
| 12 | BALYASNY ASSET MANAGEMENT L.P. | 314,637 | 5,110,000 | 1.81% | ||
| 13 | GOLDMAN SACHS GROUP INC | 300,000 | 4,872,000 | 1.72% | Call | |
| 14 | BlackRock Institutional Trust Company, N.A. | 296,199 | 4,810,000 | 1.70% | ||
| 15 | Numeric Investors LLC | 257,100 | 4,175,000 | 1.48% | ||
| 16 | ORBIMED ADVISORS LLC | 250,000 | 4,060,000 | 1.44% | Call | |
| 17 | GOLDMAN SACHS GROUP INC | 247,500 | 4,019,000 | 1.42% | Put | |
| 18 | Wildcat Capital Management, LLC | 235,264 | 3,821,000 | 1.35% | ||
| 19 | GOLDMAN SACHS GROUP INC | 221,297 | 3,594,000 | 1.27% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 210,000 | 3,410,000 | 1.21% | Call | |
| 21 | STATE STREET CORP | 209,906 | 3,408,000 | 1.21% | ||
| 22 | SABBY MANAGEMENT, LLC | 197,800 | 3,212,000 | 1.14% | ||
| 23 | AXA S.A. | 196,185 | 3,186,000 | 1.13% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 165,600 | 2,689,000 | 0.95% | Put | |
| 25 | Rhenman & Partners Asset Management AB | 154,006 | 2,501,000 | 0.88% | ||
| 26 | Ghost Tree Capital, LLC | 150,000 | 2,436,000 | 0.86% | Call | |
| 27 | GROUP ONE TRADING LLC | 144,304 | 2,344,000 | 0.83% | ||
| 28 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 140,000 | 2,274,000 | 0.80% | Call | |
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,200 | 2,147,000 | 0.76% | Call | |
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 115,197 | 1,871,000 | 0.66% | ||
| 31 | NORTHERN TRUST CORP | 102,029 | 1,658,000 | 0.59% | ||
| 32 | A.R.T. Advisors, LLC | 100,266 | 1,628,000 | 0.58% | ||
| 33 | Tourbillon Capital Partners, L.P. | 85,100 | 1,382,000 | 0.49% | Call | |
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 80,500 | 1,307,000 | 0.46% | ||
| 35 | LORD, ABBETT & CO. LLC | 80,153 | 1,302,000 | 0.46% | ||
| 36 | Bank of New York Mellon Corp | 77,783 | 1,263,000 | 0.45% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 76,114 | 1,236,000 | 0.44% | ||
| 38 | CITIGROUP INC | 75,347 | 1,223,000 | 0.43% | ||
| 39 | BlackRock Investment Management, LLC | 69,347 | 1,126,000 | 0.40% | ||
| 40 | MARINER INVESTMENT GROUP LLC | 69,000 | 1,121,000 | 0.40% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 68,609 | 1,114,000 | 0.39% | ||
| 42 | PRIMECAP MANAGEMENT CO/CA/ | 68,300 | 1,109,000 | 0.39% | ||
| 43 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 65,314 | 1,061,000 | 0.38% | ||
| 44 | FARALLON CAPITAL MANAGEMENT LLC | 65,000 | 1,056,000 | 0.37% | ||
| 45 | FIL Ltd | 56,892 | 924,000 | 0.33% | ||
| 46 | DEUTSCHE BANK AG\ | 55,234 | 897,000 | 0.32% | ||
| 47 | CITY NATIONAL BANK | 51,308 | 834,000 | 0.29% | ||
| 48 | PDT Partners, LLC | 48,805 | 793,000 | 0.28% | ||
| 49 | MORGAN STANLEY | 45,972 | 746,000 | 0.26% | ||
| 50 | SIMPLEX TRADING, LLC | 39,528 | 641,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
