| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,858,999 | 36,738,000 | 23.50% | ||
| 2 | CADIAN CAPITAL MANAGEMENT, LP | 1,529,537 | 14,561,000 | 9.32% | ||
| 3 | Numeric Investors LLC | 1,195,235 | 11,379,000 | 7.28% | ||
| 4 | VHCP Management, LLC | 1,102,735 | 10,498,000 | 6.72% | ||
| 5 | BlackRock Fund Advisors | 825,304 | 7,857,000 | 5.03% | ||
| 6 | AXA S.A. | 692,294 | 6,591,000 | 4.22% | ||
| 7 | BALYASNY ASSET MANAGEMENT L.P. | 644,981 | 6,140,000 | 3.93% | ||
| 8 | VANGUARD GROUP INC | 598,339 | 5,696,000 | 3.64% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 421,480 | 4,012,000 | 2.57% | ||
| 10 | PRIMECAP MANAGEMENT CO/CA/ | 377,800 | 3,597,000 | 2.30% | ||
| 11 | OXFORD ASSET MANAGEMENT LLP | 362,776 | 3,454,000 | 2.21% | ||
| 12 | Connor, Clark & Lunn Investment Management Ltd. | 308,350 | 2,935,000 | 1.88% | ||
| 13 | VHCP MANAGEMENT II, LLC | 280,000 | 2,666,000 | 1.71% | ||
| 14 | Gruss Capital Management LP | 260,000 | 2,475,000 | 1.58% | ||
| 15 | ROYCE & ASSOCIATES LP | 255,614 | 2,433,000 | 1.56% | ||
| 16 | STATE STREET CORP | 247,194 | 2,355,000 | 1.51% | ||
| 17 | Wildcat Capital Management, LLC | 235,264 | 2,240,000 | 1.43% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 231,897 | 2,208,000 | 1.41% | ||
| 19 | NORTHERN TRUST CORP | 217,176 | 2,068,000 | 1.32% | ||
| 20 | GOLDMAN SACHS GROUP INC | 200,000 | 1,904,000 | 1.22% | Put | |
| 21 | SABBY MANAGEMENT, LLC | 195,132 | 1,858,000 | 1.19% | ||
| 22 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 194,300 | 1,850,000 | 1.18% | ||
| 23 | GOLDMAN SACHS GROUP INC | 184,835 | 1,760,000 | 1.13% | ||
| 24 | NORGES BANK | 167,273 | 1,592,000 | 1.02% | ||
| 25 | Rhenman & Partners Asset Management AB | 154,006 | 1,466,000 | 0.94% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 150,662 | 1,434,000 | 0.92% | ||
| 27 | DAFNA Capital Management LLC | 140,600 | 1,339,000 | 0.86% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,860 | 1,046,000 | 0.67% | ||
| 29 | AQR CAPITAL MANAGEMENT LLC | 106,762 | 1,017,000 | 0.65% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 93,730 | 892,000 | 0.57% | ||
| 31 | JPMORGAN CHASE & CO | 85,724 | 816,000 | 0.52% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 82,100 | 782,000 | 0.50% | ||
| 33 | BANK OF AMERICA CORP /DE/ | 80,000 | 762,000 | 0.49% | Call | |
| 34 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 73,069 | 696,000 | 0.45% | ||
| 35 | BlackRock Investment Management, LLC | 67,905 | 646,000 | 0.41% | ||
| 36 | Bank of New York Mellon Corp | 64,831 | 618,000 | 0.40% | ||
| 37 | Jefferies Group LLC | 50,000 | 476,000 | 0.30% | ||
| 38 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 39,254 | 373,000 | 0.24% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,230 | 345,000 | 0.22% | ||
| 40 | TEACHERS ADVISORS, LLC | 31,021 | 295,000 | 0.19% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,209 | 269,000 | 0.17% | ||
| 42 | Spot Trading L.L.C | 27,000 | 257,000 | 0.16% | Call | |
| 43 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 24,743 | 236,000 | 0.15% | ||
| 44 | Redmile Group, LLC | 24,236 | 231,000 | 0.15% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,200 | 230,000 | 0.15% | Call | |
| 46 | ProShare Advisors LLC | 23,562 | 224,000 | 0.14% | ||
| 47 | Quantitative Systematic Strategies LLC | 23,492 | 222,000 | 0.14% | ||
| 48 | CREDIT SUISSE AG/ | 20,278 | 193,000 | 0.12% | ||
| 49 | J.P. Morgan Private Wealth Advisors LLC | 20,000 | 190,000 | 0.12% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 22,400 | 185,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
